Difference between revisions of "SNHG14"
(→Regulation) |
|||
| (12 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | SNHG14 | + | Approved symbol: SNHG14 |
| − | + | ||
| − | small nucleolar RNA host gene 14 | + | Approved name: small nucleolar RNA host gene 14 |
| − | + | ||
| − | UBE3A-AS1 | + | HGNC ID: HGNC:37462 |
| − | + | ||
| − | NCRNA00214 | + | Previous names: UBE3A antisense RNA 1 (non-protein coding); small nucleolar RNA host gene 14 (non-protein coding) |
| − | === | + | |
| − | + | Previous symbols: UBE3A-AS1 | |
| − | === | + | |
| − | + | Alias symbols: NCRNA00214; UBE3A-AS; UBE3A-ATS | |
| − | === | + | |
| − | + | Alias names: non-protein coding RNA 214; UBE3A antisense | |
| − | === | + | |
| − | + | RefSeq ID: NR_146177 | |
| + | |||
| + | LncBook ID: [https://bigd.big.ac.cn/lncbook/transcript?transid=HSALNT0217643 HSALNT0217643] | ||
| + | |||
| + | ===Characteristics === | ||
| + | Human UBE3A-ATS is a large (∼460 kb) transcript that initiates in the PWS-IC and extends distally through SNURF/SNRPN, IPW and overlaps UBE3A, alternatively spliced and serves as a host for several types of small nucleolar RNA (snoRNA) of the box C/D class that are contained within the introns and are expressed upon processing of the paternal copy of the host transcript<ref name="ref1" />. | ||
| + | |||
| + | ===Expression=== | ||
| + | More distal part of UBE3A-ATS, which overlaps UBE3A, is brain specific<ref name="ref1" />. | ||
| + | |||
| + | ===Regulation=== | ||
| + | Please input information here. | ||
| + | |||
| + | ===Function=== | ||
| + | The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse<ref name="ref1" />. | ||
| + | |||
===Disease=== | ===Disease=== | ||
| − | + | Angelman syndrome (AS)<ref name="ref1" /> | |
| + | |||
| + | ===Evolution=== | ||
| + | Please input evolution information here. | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> Landers M, Bancescu DL, Le Meur E, et al. Regulation of the large (approximately 1000 kb) imprinted murine Ube3a antisense transcript by alternative exons upstream of Snurf/Snrpn[J]. Nucleic Acids Res, 2004, 32: 3480-3492. | ||
| + | </ref>(1) | ||
| + | </references> | ||
| + | [http://www.lncrnadb.org/7SK/ Annotation originally sourced from lncRNAdb]. | ||
Latest revision as of 11:21, 11 August 2019
Contents
Annotated Information
Name
Approved symbol: SNHG14
Approved name: small nucleolar RNA host gene 14
HGNC ID: HGNC:37462
Previous names: UBE3A antisense RNA 1 (non-protein coding); small nucleolar RNA host gene 14 (non-protein coding)
Previous symbols: UBE3A-AS1
Alias symbols: NCRNA00214; UBE3A-AS; UBE3A-ATS
Alias names: non-protein coding RNA 214; UBE3A antisense
RefSeq ID: NR_146177
LncBook ID: HSALNT0217643
Characteristics
Human UBE3A-ATS is a large (∼460 kb) transcript that initiates in the PWS-IC and extends distally through SNURF/SNRPN, IPW and overlaps UBE3A, alternatively spliced and serves as a host for several types of small nucleolar RNA (snoRNA) of the box C/D class that are contained within the introns and are expressed upon processing of the paternal copy of the host transcript[1].
Expression
More distal part of UBE3A-ATS, which overlaps UBE3A, is brain specific[1].
Regulation
Please input information here.
Function
The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse[1].
Disease
Angelman syndrome (AS)[1]
Evolution
Please input evolution information here.
Labs working on this lncRNA
- Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
