Difference between revisions of "SNHG14"
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Latest revision as of 11:21, 11 August 2019
Contents
Annotated Information
Name
Approved symbol: SNHG14
Approved name: small nucleolar RNA host gene 14
HGNC ID: HGNC:37462
Previous names: UBE3A antisense RNA 1 (non-protein coding); small nucleolar RNA host gene 14 (non-protein coding)
Previous symbols: UBE3A-AS1
Alias symbols: NCRNA00214; UBE3A-AS; UBE3A-ATS
Alias names: non-protein coding RNA 214; UBE3A antisense
RefSeq ID: NR_146177
LncBook ID: HSALNT0217643
Characteristics
Human UBE3A-ATS is a large (∼460 kb) transcript that initiates in the PWS-IC and extends distally through SNURF/SNRPN, IPW and overlaps UBE3A, alternatively spliced and serves as a host for several types of small nucleolar RNA (snoRNA) of the box C/D class that are contained within the introns and are expressed upon processing of the paternal copy of the host transcript[1].
Expression
More distal part of UBE3A-ATS, which overlaps UBE3A, is brain specific[1].
Regulation
Please input information here.
Function
The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse[1].
Disease
Angelman syndrome (AS)[1]
Evolution
Please input evolution information here.
Labs working on this lncRNA
- Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
