Difference between revisions of "LINC00470"

From LncRNAWiki
Jump to: navigation, search
 
(3 intermediate revisions by the same user not shown)
Line 18: Line 18:
  
 
===Characteristics ===
 
===Characteristics ===
−
[[File:Functional domains of 7SK RNA..png|right|thumb|Functional domains of 7SK RNA([https://www.ncbi.nlm.nih.gov/pubmed/19246988 (Diribarne 2009)])]]
+
[[File:LINC00470 positively regulated the pAKT level.jpg|right|thumb|LINC00470 positively regulated the pAKT level<ref name="ref1" />.]]
  
 
LINC00470 (also known as C18orf2) is a long non-coding RNA located in chromosome band 18p11.32 between RP11-16P11 and RP11-732L14, Its alternative splicing of seven exons generates four transcripts<ref name="ref1" />.
 
LINC00470 (also known as C18orf2) is a long non-coding RNA located in chromosome band 18p11.32 between RP11-16P11 and RP11-732L14, Its alternative splicing of seven exons generates four transcripts<ref name="ref1" />.
Line 29: Line 29:
  
 
===Function===
 
===Function===
−
[[File:Model of hLarp7 recognition of the 7SK.png|right|thumb|Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP([https://www.ncbi.nlm.nih.gov/pubmed/29946027 (Eichhorn 2018)])]]
+
[[File:LINC00470 inhibited HK1 ubiquitination to affect glycolysis by positively regulating AKT activation.jpg|right|thumb|LINC00470 inhibited HK1 ubiquitination to affect glycolysis by positively regulating AKT activation<ref name="ref1" />.]]
  
 +
LINC00470 was a positive regulator for AKT activation in GBM. LINC00470 bound to FUS and AKT to form a ternary complex, anchoring FUS in the cytoplasm to increase AKT activity. Higher pAKT activated by LINC00470 inhibited ubiquitination of HK1, which affected glycolysis, and inhibited cell autophagy<ref name="ref1" />.
  
 
===Disease===
 
===Disease===
Line 43: Line 44:
 
* Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, 410006, Hunan, China.
 
* Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, 410006, Hunan, China.
 
* Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, Hunan, China.
 
* Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, Hunan, China.
 +
* Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, Hunan, China.
  
 
==References==
 
==References==

Latest revision as of 12:40, 11 August 2019

Annotated Information

Name

Approved symbol: LINC00470

Approved name: long intergenic non-protein coding RNA 470

HGNC ID: HGNC:1225

Previous names: chromosome 18 open reading frame 2

Previous symbols: C18orf2

RefSeq ID: NR_023925

Ensembl ID: ENSG00000132204

LncBook ID: HSALNT0246856

Characteristics

LINC00470 positively regulated the pAKT level[1].

LINC00470 (also known as C18orf2) is a long non-coding RNA located in chromosome band 18p11.32 between RP11-16P11 and RP11-732L14, Its alternative splicing of seven exons generates four transcripts[1].

Expression

LINC00470 expression levels in astrocytoma were significantly higher than those in normal brain tissues, high expressed in GBM[1].

Regulation

Please input regulation here.

Function

LINC00470 inhibited HK1 ubiquitination to affect glycolysis by positively regulating AKT activation[1].

LINC00470 was a positive regulator for AKT activation in GBM. LINC00470 bound to FUS and AKT to form a ternary complex, anchoring FUS in the cytoplasm to increase AKT activity. Higher pAKT activated by LINC00470 inhibited ubiquitination of HK1, which affected glycolysis, and inhibited cell autophagy[1].

Disease

astrocytoma [1]

GBM[1]

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, 410006, Hunan, China.
  • Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, Hunan, China.
  • Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, Hunan, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Liu C, Zhang Y, She X, et al. A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy[J]. J Hematol Oncol, 2018, 11: 77.

Sequence

>gi|193083199|ref|NR_023925.1| Homo sapiens long intergenic non-protein coding RNA 470 (LINC00470), transcript variant 1, long non-coding RNA

000001 AATGCCTTAA AGAAAGGACT GATCTCCCCT GAAGAAGAGA GAATTCTGCC TCTAGATTGC TTACAATTTG AACTGGAACA 000080
000081 TCAGCTGTTC TCTAGGTCTT AAGTCTGCTG CTCTAACCTA CAAATTTTGG ACATGCCAAT CTCCACAGTC ACATGGGCCA 000160
000161 ATTCCTTAGT TTCTCTGGAG AATCCTGACT AATGTATGCA ATGTCTTTAT TTCATCCTCA TTCTTAAAGG ATATTTTCAT 000240
000241 CAGCAACACC ACACCCTCCT GATCACCATA GCTTTATGAT CTGAGCTTTC ATCTGGTATC ATTTCCTTTC CGTCTGAAGA 000320
000321 ACTTGCTTTC CTTGCAACAA CAAGAAACAA ATTTATTAGC TAACCTAACC ACTAATGACG CAAGAGACAA TTCTAAGGAC 000400
000401 TTTCAAAACA GCAAAGTAGG AGCAGCTGCT ACCTCTAGGG ATGAGGGAGA AACTCAAAAA TGCATACAAA AACCATTGCA 000480
000481 TGAAAAGTGA CTGGATTTGT ACATAGCGTC AGGAGATGTG CGTAGTGTCA AAGTATCTCA TCACACATTA CTTGATAATT 000560
000561 ACAAATGAGA AAAATGAACC TTCACAGTGG CAAGACTTGA CTTCTACCTC TTTCAAAAAG ATGCAATTGT CCAATTATTG 000640
000641 GTGAAATTGT CATTTCATGC TATTGGCTAT TTGAAATTCC TCCTCTAATT TCAGAATAAA TCACTGAAAT TGACATCGGC 000720
000721 CAGTCTGAAT TTCAAGAAAT TACCTGCTGA AGACAAGAGG GATCTCTTCT TCAGATTTGC AGTCTGGGGA AGACACAGCC 000800
000801 TCTACTGTAC TTTAGAACCT GAGATATGGT GGTGGAGGGA GCCCTGGGTC GAGTGGTAAG ATTCACCCTT AGGTTAGTAT 000880
000881 TGACGTAAGG TGACGAGGAG CTGTAGACAA AAGATTGTAA CCATAAGAAC TTCATAGTTT TTGTATTTTC ACCGAGCTTA 000960
000961 TATTTGGTGT GTTTTTTGTC TTTTCTTTAT GATTATCAAT AAAATGCTTG AAAGGAGATG AGGTTGGGGA ATAATTTTTG 001040
001041 GGAATACCAC AAAAGACACT TTTGTGATGG AAATCCTTAA AAAGACACAA TCCATTACCT CATTGGGTTC AAAAGGCAAT 001120
001121 TGTGAACTAC TGTGGAGTTT GGAAAGAAGC AATGAGGTAA TCAAGGATAC TGTTGACAAT CTAGCTTATC CTATGGATGG 001200
001201 AAGGAAATTG AAACTAATGG AGGCGAGGCT GGTAAAACAA TAGGGTTTGA GACAATTCTG TGGCATTAGA AATGAAAGAG 001280
001281 GAAGGTGAAT CCGGGAGACG GAGCTTGCAG TGAGCTGAGA TCGCGCCACT GCACTCCAGC CTGGGCGACA GAGCGAGACT 001360
001361 CCATCTCAAA AAAAAAAAAA AAGAAAGAAA GAAAAGAAAG AGGAAGTAAT AATCTGTGAA ATTTTTCCTT AGGAACTTAT 001440
001441 TGGCAATTTA AAAATGAATT TGTTAAGCCA TGCTGGTTCT GACCCAAAAG CCATTCCCCA GCCTTCCTCA CTCCCCTCTT 001520
001521 TCACTACTGG CAGAGATTGT CTCTCATTTT ACAAGCTGAA AATGCCAGAT GCTTGCTTTT ACAGTCTTCC TTACACCCAG 001600
001601 AGCATGTGCA TATGTTTAAA CGGTCAAGAA GAAGTCATAA CATGGGTGTC TGGGAGAGCT TTTATCCCAC AAAAACAACA 001680
001681 CTTCACTCAA AAAACAAACC AAACAAAGAA AAATTCTCCT TCCTGCCATT GGATGTGAGG CTCAGACCTC TAGTAACCAT 001760
001761 TTTGTGACCA CAAAGCAACA AGCCTGAGGA AAAGTCCTAC ACGCTGAGCA ACAGGCAGAA ATATTGCCAT CGCTGAGTTG 001840
001841 CAGAAACAAA TCTAGAGATG TTTTGCTTCT GTA<