Difference between revisions of "FAM201A"
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2017 Nov 3. doi: 10.1093/bib/bbx153. | 2017 Nov 3. doi: 10.1093/bib/bbx153. | ||
</ref>(1) | </ref>(1) | ||
| + | <ref name="ref2">Yu D, Mathews CA, Scharf JM, et al. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD[J]. Am J Psychiatry, 2015, 172: 82-93.</ref>(2) | ||
| + | <ref name="ref3">Matsumura K, Kawasaki Y, Miyamoto M, et al. The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration[J]. Oncogene, 2017, 36: 1191-1199.</ref>(3) | ||
| + | <ref name="ref4">Huang G, Zhao G, Xia J, et al. FGF2 and FAM201A affect the development of osteonecrosis of the femoral head after femoral neck fracture[J]. Gene, 2018, 652: 39-47.</ref>(4) | ||
</references> | </references> | ||
[http://www.lncrnadb.org/7SK/ Annotation originally sourced from lncRNAdb]. | [http://www.lncrnadb.org/7SK/ Annotation originally sourced from lncRNAdb]. | ||
Revision as of 14:22, 11 August 2019
Contents
Annotated Information
Name
Approved symbol: FAM201A
Approved name: family with sequence similarity 201 member A
HGNC ID: HGNC:27239
Previous symbols: C9orf122
Previous names: chromosome 9 open reading frame 122; family with sequence similarity 201, member A
RefSeq ID: NR_027294
Ensembl ID: ENSG00000204860
LncBook ID: HSALNT0288968
Chromosome
9p12
Characteristics
Overexpression of lncRNA FAM201A is highly correlated with the radiosensitivity of ESCC and is associated with poor surviva[1].l
The FAM201A gene is a 2.9 Kbp long gene located in genomic 9p13.1, that results in RNA transcripts without ORFs, which means that it has no protein-coding potential.
Expression
FAM201A was upregulated in radioresistant ESCC tumor tissues[1].
Regulation
Function
Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP((Eichhorn 2018))
FAM201A contributed to radioresistance by upregulating ataxia telangiectasia mutated (ATM) and mammalian target of rapamycin (mTOR) expression via actions as a miR-101 sponge， may be a potential biomarker for predicting radiosensitivity and patient prognosis, and may be a therapeutic target for enhancing cancer radiosensitivity in ESCC.[1].
Disease
- colon adenocarcinoma [1]
- Obsessive-compulsive disorder[2]
- Tourette's syndrome[2]
- colorectal[3]
- Osteonecrosis of the femoral head[4]
Evolution
Please input evolution information here.
Labs working on this lncRNA
Please input related labs here.
References
- ↑ 1.0 1.1 1.2 1.3 Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.
- ↑ 2.0 2.1 Yu D, Mathews CA, Scharf JM, et al. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD[J]. Am J Psychiatry, 2015, 172: 82-93.
- ↑ Matsumura K, Kawasaki Y, Miyamoto M, et al. The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration[J]. Oncogene, 2017, 36: 1191-1199.
- ↑ Huang G, Zhao G, Xia J, et al. FGF2 and FAM201A affect the development of osteonecrosis of the femoral head after femoral neck fracture[J]. Gene, 2018, 652: 39-47.
Annotation originally sourced from lncRNAdb.
Sequence
>gi|224591428|ref|NR_027294.1| Homo sapiens family with sequence similarity 201 member A (FAM201A), long non-coding RNA
000001 GAGTGCACCT GGCCTGAGAG CCCGCCAGGC CCTGCCCCTG CTCGGCTCCT CGTCTGCTGA AGCTCGGGAC CTCTAGCCAG 000080
000081 TGGCCCTCTG CAGCCACGGG GAATGGGGCT GAGAGCCGGT TCCCGCTGCA GGGCAGACCA CCTAGCTCAG CCGCAGCCAC 000160
000161 AGGGACATCT GGCCCCGGTT CTGAGATGTG GGGAGTGCTG GCGGGCTCGG GGGTTGCCTG GAGGCTGCTG CCTGCACACA 000240
000241 GAAGGCGGAT GCAGCTTGGG TGCCCAGGCG GGCTGGAGGA CAGCGGGCTG GGAAGCCAGG GGCCGCCGGG ACCTGGGGCT 000320
000321 GGAAACCACA TCTGCCCACA GCCGCAGCCT CCTGCACCTG TCATCCTGGC GGCGCCCTGA CGTCGGAGAA GCAGCAGGCG 000400
000401 CGGAGCTCCT GCAGCGGGCA CCGCTGCAGC AACCCGACCC GGCGCAGGCG GCAGTGGAAG GCGGCCTGCT AGCACGGCTC 000480
000481 CCGCGGCCCC AGGACCAGGG GTGCGGCCAG CACCGCCCTC ACTCCCCGCG TCTCGTGGAT ATTGCCCTCC CTGGAGGCGG 000560
000561 CTGGACCTAA GCGAGGCTCG CAGCGATCGG CCCCGCGAAG ACTCGCATGC AGGGCTCAGG ATCCCGCATT CTGGCGCCGC 000640
000641 GGCACCGCAC CTTTCAGCAG CCCTGCTCCT CTTCTTGTTG GTAAACTTTT GTCACTCTGC CATGAAAAGC ATCCAGGCGT 000720
000721 CCTTGATTTC GACATTGCGT GCACGCTCAG CCGAGCTCAT CAGACGGGCG GTTGTCCCCA GAGCCCGCGG GTAGCTTGTT 000800
000801 CCCGGGCGGC GGCTCCTGCT GGATGCAGCT CCTTGTGGGC CTACCAGGCT TGGTGGAGCC ACAGCAGACC TGTGGAGAGG 000880
000881 AAGAGTAAGG CGGGCTCTGC AGGGCAGTGG GCCGGGACCA TGAGAGAGGC GGGTCAGTCT GGGCTCCAAG CTCAGCCTCT 000960
000961 CGGATTCCCC GGGACCCACG GCTTATAATG CGCTTAAATC CCACGCCTCG CCCGAGAGAC AGCACGTCAC CGTCACCGTC 001040
001041 ACCGCCTAGC GCCCCTGACC CGCTCCCACT CCGCTGCAGC GGAGGGTGTG TGAGGGAGAG GGACGCAGGG AGGGAAAAGC 001120
001121 GTTGGGAGGG CAAACATCTT TTCATAAGCT TTTCCCCTTC TATATGCCAT CTCTGATGGG AGCCTCTTTA GATCTTTCGT 001200
001201 CCATTTACTA ATTGGGTTGT TCGATTTCTT ATTGTTGAGT TGTAAGTGGT TTTTAATGGT CTGGATGCCA GACAGGTGTT 001280
001281 TTGCAAATAT TTTCTCCGTC TGTGGCTTGT TTCTCCATTC TCTTATTTCC TTTCCCAGAG CAAAAGTTTT TAATTGTAAC 001360
001361 GACTTCATAC CAATATCTTC TTTCATGGTA GAAATTTGTC TTTTATGTAC TTTACTGTTG TATCTACAAA GTAATTGCCA 001440
001441 AACCCAAAGT TACCTAAATA TCCCTTTTGT TATTTTACAG AAGTTTTACA GCTTTTGGAT TTAAATTTAG GTCTAAAAAT 001520
001521 TGAATTCATA AAAGTAGAGA GTATAATGAT GCTTACCAGA GGCTGTGTTG CTGGGGAGAA AAATGGGAAG TTGTTCACAG 001600
001601 ATGCAAAGAT TCAGTTAAAC CGGAGAAATG CGTTTTGAAA TCTATTGCAC AGCAGGATGA CTATAGTCAA TAATAATGTA 001680
001681 CTGTATATTT AAATAACAAA AAGTAAATTT CAAATATCTA ACCACAAAAA AAAAAAAAAA A
000081 TGGCCCTCTG CAGCCACGGG GAATGGGGCT GAGAGCCGGT TCCCGCTGCA GGGCAGACCA CCTAGCTCAG CCGCAGCCAC 000160
000161 AGGGACATCT GGCCCCGGTT CTGAGATGTG GGGAGTGCTG GCGGGCTCGG GGGTTGCCTG GAGGCTGCTG CCTGCACACA 000240
000241 GAAGGCGGAT GCAGCTTGGG TGCCCAGGCG GGCTGGAGGA CAGCGGGCTG GGAAGCCAGG GGCCGCCGGG ACCTGGGGCT 000320
000321 GGAAACCACA TCTGCCCACA GCCGCAGCCT CCTGCACCTG TCATCCTGGC GGCGCCCTGA CGTCGGAGAA GCAGCAGGCG 000400
000401 CGGAGCTCCT GCAGCGGGCA CCGCTGCAGC AACCCGACCC GGCGCAGGCG GCAGTGGAAG GCGGCCTGCT AGCACGGCTC 000480
000481 CCGCGGCCCC AGGACCAGGG GTGCGGCCAG CACCGCCCTC ACTCCCCGCG TCTCGTGGAT ATTGCCCTCC CTGGAGGCGG 000560
000561 CTGGACCTAA GCGAGGCTCG CAGCGATCGG CCCCGCGAAG ACTCGCATGC AGGGCTCAGG ATCCCGCATT CTGGCGCCGC 000640
000641 GGCACCGCAC CTTTCAGCAG CCCTGCTCCT CTTCTTGTTG GTAAACTTTT GTCACTCTGC CATGAAAAGC ATCCAGGCGT 000720
000721 CCTTGATTTC GACATTGCGT GCACGCTCAG CCGAGCTCAT CAGACGGGCG GTTGTCCCCA GAGCCCGCGG GTAGCTTGTT 000800
000801 CCCGGGCGGC GGCTCCTGCT GGATGCAGCT CCTTGTGGGC CTACCAGGCT TGGTGGAGCC ACAGCAGACC TGTGGAGAGG 000880
000881 AAGAGTAAGG CGGGCTCTGC AGGGCAGTGG GCCGGGACCA TGAGAGAGGC GGGTCAGTCT GGGCTCCAAG CTCAGCCTCT 000960
000961 CGGATTCCCC GGGACCCACG GCTTATAATG CGCTTAAATC CCACGCCTCG CCCGAGAGAC AGCACGTCAC CGTCACCGTC 001040
001041 ACCGCCTAGC GCCCCTGACC CGCTCCCACT CCGCTGCAGC GGAGGGTGTG TGAGGGAGAG GGACGCAGGG AGGGAAAAGC 001120
001121 GTTGGGAGGG CAAACATCTT TTCATAAGCT TTTCCCCTTC TATATGCCAT CTCTGATGGG AGCCTCTTTA GATCTTTCGT 001200
001201 CCATTTACTA ATTGGGTTGT TCGATTTCTT ATTGTTGAGT TGTAAGTGGT TTTTAATGGT CTGGATGCCA GACAGGTGTT 001280
001281 TTGCAAATAT TTTCTCCGTC TGTGGCTTGT TTCTCCATTC TCTTATTTCC TTTCCCAGAG CAAAAGTTTT TAATTGTAAC 001360
001361 GACTTCATAC CAATATCTTC TTTCATGGTA GAAATTTGTC TTTTATGTAC TTTACTGTTG TATCTACAAA GTAATTGCCA 001440
001441 AACCCAAAGT TACCTAAATA TCCCTTTTGT TATTTTACAG AAGTTTTACA GCTTTTGGAT TTAAATTTAG GTCTAAAAAT 001520
001521 TGAATTCATA AAAGTAGAGA GTATAATGAT GCTTACCAGA GGCTGTGTTG CTGGGGAGAA AAATGGGAAG TTGTTCACAG 001600
001601 ATGCAAAGAT TCAGTTAAAC CGGAGAAATG CGTTTTGAAA TCTATTGCAC AGCAGGATGA CTATAGTCAA TAATAATGTA 001680
001681 CTGTATATTT AAATAACAAA AAGTAAATTT CAAATATCTA ACCACAAAAA AAAAAAAAAA A
Predicted Small Protein
| Name | FAM201A_smProtein_185:379 |
| Length | 64 |
| Molecular weight | 6456.4265 |
| Aromaticity | 0.03125 |
| Instability index | 83.928125 |
| Isoelectric point | 9.00665283203 |
| Runs | 9 |
| Runs residual | 0.00796875 |
| Runs probability | 0.0270073995564 |
| Amino acid sequence | MWGVLAGSGVAWRLLPAHRRRMQLGCPGGLEDSGLGSQGPPGPGAGNHICPQPQPPAPVI LAAP |
| Secondary structure | LEEEELLLLHHHHLLHHHHHHHLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLEE EELL |
| PRMN | - |
| PiMo | - |
