Difference between revisions of "LINC00346"

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===Characteristics ===
 
===Characteristics ===
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[[File:Functional domains of 7SK RNA..png|right|thumb|Functional domains of 7SK RNA([https://www.ncbi.nlm.nih.gov/pubmed/19246988 (Diribarne 2009)])]]
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[[File:High LINC 00346 expressions in NSCLC tissues and cells.png|right|thumb|High LINC 00346 expressions in NSCLC tissues and cells<ref name="ref1" />.]]
 
LincRNA 00346 (LINC 00346) belongs to the intergenic lncRNA, located on the chromosome 13q34 with a total length of 6322bp<ref name="ref1" />.  
 
LincRNA 00346 (LINC 00346) belongs to the intergenic lncRNA, located on the chromosome 13q34 with a total length of 6322bp<ref name="ref1" />.  
  
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===Regulation===
 
===Regulation===
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Please input regulation information here.
  
 
===Function===
 
===Function===
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[[File:Model of hLarp7 recognition of the 7SK.png|right|thumb|Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP([https://www.ncbi.nlm.nih.gov/pubmed/29946027 (Eichhorn 2018)])]]
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[[File:LINC 00346 regulates the JAK-STAT3 signaling pathway.png|right|thumb|LINC 00346 regulates the JAK-STAT3 signaling pathway]]
  
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LINC00346 used as a biomarker for prognosis estimation in breast cancer, plays a similar role to oncogene in bladder cancer to promote the formation of malignant phenotype of tumors<ref name="ref1" />.
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LINC 00346 could exert its function through partially regulating the Janus kinase/signal transducer and activator of transcription 3 (JAKSTAT3) signaling pathway to inhibit the in vivo tumorigenic ability of tumor cells<ref name="ref1" />.
  
 
===Disease===
 
===Disease===
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==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
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Please input related labs here.
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* Department of Oncology, Dongying People's Hospital of Shandong Province, Dongying, China.
  
 
==References==
 
==References==
 
<references>
 
<references>
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<ref name="ref1"> Shahriyari L. Effect of normalization methods on the performance of supervised
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<ref name="ref1">Wang F, Chen JG, Wang LL, et al. Up-regulation of LINC00346 inhibits proliferation of non-small cell lung cancer cells through mediating JAK-STAT3 signaling pathway[J]. Eur Rev Med Pharmacol Sci, 2017, 21: 5135-5142.
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learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a
 
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predictor of survival in patients with colon adenocarcinoma. Brief Bioinform.
 
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2017 Nov 3. doi: 10.1093/bib/bbx153.
 
 
</ref>(1)
 
</ref>(1)
 
</references>
 
</references>

Latest revision as of 03:09, 12 August 2019

Annotated Information

Name

Approved symbol: LINC00346

Approved name: long intergenic non-protein coding RNA 346

HGNC ID: HGNC:27492

Previous symbols: C13orf29; NCRNA00346

Previous names: chromosome 13 open reading frame 29; non-protein coding RNA 346

RefSeq ID: NR_027701

Ensembl ID:ENSG00000255874

LncBook ID: HSALNT0289506

Chromosome

13q34

Characteristics

High LINC 00346 expressions in NSCLC tissues and cells[1].

LincRNA 00346 (LINC 00346) belongs to the intergenic lncRNA, located on the chromosome 13q34 with a total length of 6322bp[1].

Expression

LINC00346 is up-regulated in hepatocellular carcinoma, breast cancer and non-small cell lung cancer[1].

Regulation

Please input regulation information here.

Function

LINC 00346 regulates the JAK-STAT3 signaling pathway

LINC00346 used as a biomarker for prognosis estimation in breast cancer, plays a similar role to oncogene in bladder cancer to promote the formation of malignant phenotype of tumors[1].

LINC 00346 could exert its function through partially regulating the Janus kinase/signal transducer and activator of transcription 3 (JAKSTAT3) signaling pathway to inhibit the in vivo tumorigenic ability of tumor cells[1].

Disease

non-small cell lung cancer [1]

hepatocellular carcinoma

breast cancer

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • Department of Oncology, Dongying People's Hospital of Shandong Province, Dongying, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Wang F, Chen JG, Wang LL, et al. Up-regulation of LINC00346 inhibits proliferation of non-small cell lung cancer cells through mediating JAK-STAT3 signaling pathway[J]. Eur Rev Med Pharmacol Sci, 2017, 21: 5135-5142.

Sequence

>gi|237874147|ref|NR_027701.1| Homo sapiens long intergenic non-protein coding RNA 346 (LINC00346), long non-coding RNA

000001 AAACGCCCTC CAGGGTGATG ACTGTGGGAG CAAAACTGAC CGGAACCTGG GCGGTGCATG CACTGTGCAC CCTCCTGGTT 000080
000081 AACAGCCCCA CGGCCCGAGA GCTGTGCTTT ACATGAATGT CTTCTGTTAA AGCAGCTCGT GTGGCTTCTG CACCCTGGTG 000160
000161 GAGCCAACAC ACGTGCCTGT CACGGAGGTG AGGAGTGAGT GAGTTCTCAC CAGCATTTGA CGCTGACCTT CCGGAGACAT 000240
000241 GGCGTCCCTG AGAGCCTGCA GCCTGCCAGA GCAGAGAGCC ACCCGCTGGC CGTTCTGTTG GAATTTCGGA GTTCCTGTCT 000320
000321 TTCAGGCAAC ATCTGCCAAG CGCGGTTTGT GTAAGGAAAC CCATTCTGTC GTGTCTGCCG GGGCCCAGGG CGGCTGCTGT 000400
000401 GCGGGAACCA GCTTTTGTGG CCCATGGAGC AACGACTCAG TCTGGGGCTC GGCTACTCTC CGGCCCGGGG TACTGGCATT 000480
000481 TCCCTGGGGC CCATGGGGCG AGTGCCCCTA TTTTTCCCAT GAGGCCTCAG CCAAGAGGAG GTTCGGGAAG AAAGGAAAAC 000560
000561 ACAGGTGAGG AGAGAGAAGG GCGGGCAGAG AGGTACCACG CCATTAGTGC TGATGGGGAG AGGCGGCTCC AGCCCGGCAC 000640
000641 TGCTGTCCTT ACGAGGCATG TTTCCTTTTT ATTCGGAGGA AGAGAAGCAG AGGAACACGT CATGGAGACG GACCGAGTTG 000720
000721 AAGGAGCCAG GGATGGTGAC AAGCGGAAGG AAGTGTGTTT TGTCCCCATC CAGGGAAGCT TTTGTTTCAT GAGACTTACT 000800
000801 TGCGCACGTC TGGTAGCTGC CCTGGACATT CATGGACTTT CGTTTTCACT CAGATTTTGT GGTTCACGTG ACACAAAGCA 000880
000881 TGAGGACATC ACTGGGCGAG AGGGCCAGGT CACCCCACTG CCGAGGGGCA CGCCCCAGCT GTGCACCGCT AGAGTGGGCT 000960
000961 TGTCCAGTCC TCGGACACGG GGACAGGGTG TGCCCATCTC ATGTAAGACA TGAATAATAG TAGAAATTTC TGTTGCATGA 001040
001041 GAACTCTCTG CATTATCCTC ACCATTTTCC TGTAAGCGTA AAACGTCTAA AACTTTTTTA TGAGCACACT AATTCCTCAC 001120
001121 TTAAGGTCGT CATTAGGTTC TTGGAAATGG CAACTTTAAA CAAAAGGACA GACAGCAGGT CCTCAAATAA CATTCTTTCC 001200
001201 TTCAACATCA TTTCATCCTA AGGAGAAAAA AATGGATTTT GTTACATATC CTGGTTCATT TCCAAGAACC AGGTGGGCAT 001280
001281 AGAATTGACC AAAGGTGGAG GAGAACAGAT GTGCGGCTCC GTCCTGGCTG TGTGGCTCCG TCCTGTGGAC TAATGCGTGT 001360
001361 GGACAGTCAG GAACACTTTC AGGACAATGT GGGTGGCCTG CCAATGGGAC CTATTCCAGA GGTCTGAGAA GAAACCGTTG 001440
001441 TTTAACCTAG AATCCTGCTA GGAATCAAAC TAGCTTTGAC AGGAAAAGGA AAAAGAATGA GGACTCTGAA CAGGGACAGA 001520
001521 CTCAGAACAA TTCTTATCCA CTCATAGTTT AGGAAATAAT CTTACAGCAT GTGCTCCACC AGGGTCACCA ACTGTCCCAA 001600
001601 TTTGCTTGGG ACTGAAGGTT TGTTTGTTTT TGTTTCTTTG TTTTGAGACA GAGCGTCTCT CTCTGTTACC CAGGCTAGAG 001680
001681 TGCAATGGCG TGATTTTAGC TCACTACAAC CTCCACTTTC CAGGTTCAAG CAATTCTCCT GTCTCAGCCT CCCTGAGTGG 001760
001761 CAGGGATTAC AGGAACCCAC CACCATGCTG GCTAATTTTT CAATATTTAG TAGAGATGGG GTTTCACCAT GTTGGCCAGG 001840
001841 CTGGTCTCGA ACTCCTGACC TCAAGTGATC CACTTGCCTC AGCTCCCAAA GTGCTGGGAT TACAGGCATG AGCCACCGTG 001920
001921 CCCAGCCTAC TGAGGGGTTT TTATGGACAT GGGACTTTTA ATGCTAACAC TAGGACAGTC TCTGTCAGAC TGAGATGATG 002000
002001 GTCACTCTTT GGCCAAACAC CTCCACCACT GCCCCGCAAC ATCCATAATA GCAACAGTTT GAGTAAAGAC ACAAGTACCA 002080
002081 TTTGCGGTCC AAATACTTGA GTGTGTAAAC GGTGCATTGG GTGTGCACAG CGGTACCCAG AATCTCCAAC TAGCTCCTCA 002160
002161 TGAGCTGGGT GGGGCATGCA GGGAAGGAGG CAAAGCTTCC CACCTGTCTG GGGAGGCTGT GGGCTCCACC TCTGCAGACT 002240
002241 TTGGTAGGAG ACCAGTGTTC ATGCAGTTGT AGTAATGCAC GTGTAGCTTA GGGTTTTTTT GGGACTAAAC TATGGACAAA 002320
002321 GCACAGAACT CAGTTGTCTC TGTAGAAAAG GGTGGCCTGT CACCCGGTAC CAGGTGAGGG GAGTGTGGCA GTGGCAAGAG 002400
002401 CACCTGGTGG TGGCCGAGAG GAGGCACGGA GGAGAGTCAG GGTACCGTGC CCTCATGGAG TGAGTGCGGA AGACAAAACA 002480
002481 ACAGACACAG TTGTAATGAC ATTACTTTAT TTGGGGTTAA ATTAGGGTGC ACATCACAGA AAATCCTCAA ACCACAGGGA 002560
002561 ATGAAATGGA AGTTGTTTCT CTCTGGTAAA ACAAGTCTGA AAGCTGCAGT GTCATCAGAT CCACGGCCCT GCATCTCTGC 002640
002641 CACACCCCAC CATGCACCTC CAGTCCTCCC GGCCTGTGGC TTCCAGGGCT CCAGGAACTA GGGAGGGACA GACACTGGGA 002720
002721 TCTTCTGCCA TGAAGCAGAG AGGGATGCTG GGGAAACACA TGGGCACTCG CTGCCACAAG TGCCTCCTGG AAAAGCAAAA 002800
002801 CCCAATGCCA TGGCTGCCTC CCTCCGGCAG CACCAGCACG AGTGAGCCAG ATCCTCACCT TTGATCATCA AGGCTGAGAG 002880
002881 GTAATATCTG AGGTCGACAG ATCAAGAAGT AGAGACAAAA GCAAACCAGG CTGGTGGTAA AGAGGAGGAA TGACCGTAAG 002960
002961 ATGCCTCTGA AAAGTGGGAA TATGGGGAAT CTCCTCTTGG TTTCTGGTTG CACATGTGAA TTTATTGAAA ACTGAATATA 003040
003041 TTAAGATGTG AGCTTAGGAG TTGGCAGCCT GTGGCATGGG GAGGTGTGGG AAGTGGACAG TCTCAGGTCA GGGTGGGCTG 003120
003121 GAAAGTGGTG CCACCTCGAG AACAGTAGGT TAACATCTAC CCCCAGTGAC GACATTCAAA CCTTCATCCA GCATCCACTT 003200
003201 CCAGGGGACA TTTTCACAAA ATATTCACGA GAGCACACAA AATATACAAA GGATGACGAG GGTTGAACAT TGTTGTGACA 003280
003281 AAACATGGGA AGCAACTTAA GTGCCATCTG TGGGAAACGG TCTAGTGGTG GAGCTGTGGG GCTGTGGGAT ACTGTGGGCG 003360
003361 GGTGAGAAAC GGAGAGGCGT CTCCAAGCAT CAGTGGGATA AAATTGCTCT ATCTGTATTT TCAAAGGAGA AAAAGAACAA 003440
003441 GCCCCAAGCT GTGCATTTAC ACGGGGACAT GAGTACATCC ATCTGTAATG CGTCTGTCAC CCCACAACAG GAGGGGTTAG 003520
003521 CTGTGCGTGG GGAGAGGGTG AAGAAGGGCT TTTGCCTGGT GCTAGACTGC CTGGGTTCAA ATCCTGCTCC TACTTAGTGC 003600
003601 TGTGCAATTT GGGCAAAATA CCTAAACCTC TCTGTGCCTT CATTTCCACC TCTCTAAAGC GGGGTCTGTG ACAATGCCCA 003680
003681 CTCCTCATTC ATAAGGTGGT GGTGAGGATT AAATGAGCTG ATGCCCTCAC AAGGTGTTTG TCCATCAGTG ATAGGGTTTG 003760
003761 GCTGTGGCCC CTGTGTCCCC ACCCAAATCT CATCTTGAAT TGTAATCCTC ATAATCCCCA CGTGTCGAGG GAGGGATCCC 003840
003841 GTGGGAGGTG ATCAGATCAT GGGGGTGGTT CCCCCATGCT GTCCTCATGA TAATGAGTGA GTTCTCACGA GATCTGATGG 003920
003921 TTTTATAAGG CAGTTTCCCT GCTCTTACAC GCTCTCTTTT GCCTGCCGCC ATATAAGACA TGGCTTTTCC CTTTCCACCA 004000
004001 TGATTGTAAG TTTCCTGAGG CCTCCCCAGT CATACAGAAC TGTGAATCAA TTTAACCTCT TTCCTTTATA AATTGCTCAG 004080
004081 TCTGAGGTAG TTCTTTATAG CAGTATGAGA ATGAACTAAC ACAGTAAATT GGTACTGCGG AGAGTAGAGT ATTGCTATAA 004160
004161 AGATACCCAA AATGTGGAAG CAACTATGGA ACTGGGTAAC AGACAGAGAT TGGAACAGTT TGGAGGGCTC AGAAAAAAGA 004240
004241 CAGGAAGATG TGGGGAAGAT TGGAACATCC TAGAGACTTG TTGAATGGTT TTGACCAAAA TGCTGATAGT GATGTGGACA 004320
004321 ATAAAGTCCA GGCTGCGGTG GTCTCAGATG GAGATGAGGA ACTTCTTGGG AACTGGAGTA AAGGTCACTC TTGCTACGCT 004400
004401 TTAGCAGAGA CTGGTGGCAT TTTGCCCCTG CCCTGAGATC TGTGGAACTT TGAACGTGAG AGAGATAACC TGAAATTGGA 004480
004481 ACACATGTTT ACGAAGAAGC AGAGCATTAA CATTTGGAAA ATTTGCAGCC TGACAATATG ATAGAAAAGA AAAACCCATT 004560
004561 TTCTGGGGAG AAATTCAAGC TGGCTGCAGA AGTTTGCATA AGTAACGAGG AGCCAAAGGT TAGTCACCAA GACAATGGGG 004640
004641 AAAATGTCTC CAGGGCATGT CAGAGGCTTC GCAGCAGCCC CTCTTAGCAC AGGTCTAGGA GGGAAAAATG GCTTCATGGG 004720
004721 CCAAGTCTAG GGCCCCACTG CTCTGTGCAG CCTCTGGACT GGATGCCTTC TGTCCTAGCT GCTGCCACTC AAACTCCAGT 004800
004801 CGTGGCTAAA AGGGGCCACA TACAGCTCAG GCTGCTGCTT CAGCGGGTGC AAGCCGGAAG CCTGCACAGA ATTCAAGAAT 004880
004881 TGAGGTTTGG GAACTTCTGC CTAGATGTCA GAGGAAGTAT GGAAACAGCT GGCTGTCTAG GCAAAAGTTT GCTGCAAGGG 004960
004961 TGGAACCCTC ATGGAGAACG TTAGGGCAGT GAGGAAGGGA AATATGGGGC TGTAGCCCCC ATAACAGAGT ACCCACTGGG 005040
005041 TCACTGCCTA GTGGAGCTGT AAGAAGAGGG CCACCATCCT CCAGATCCCA GAATGTAGTC CCACTGACAG CTTGCACTGT 005120
005121 GGCCTGGAAA AGCTGCAGAC ACTCAATGCC AGCCCACGAA AGCAGCCAGG AGGGGGGCTG TACCTTACAA AGCCACAGGA 005200
005201 GCAGAGCTGC CCAAGACCAT GGGAACCCAC CTCTTTCATA AGCGTGACCT GGATGTGAGA CATGGAGTCA AAGGAGATCA 005280
005281 TTTGGGAGCT TTAAGATTTA ATGATTGCCT CACTGGATTT TGGACTTACA TGGGGCCTAT AGCCCCTTTG TTTTGGCCAA 005360
005361 TTTCTCCCAT TTGAAATGGA ATCATTTACC TAATGCCTGT ACGCCCATTG TATCTTGGAA GTAACTAACT TGGTTTTGAT 005440
005441 TTTACAGGCT CATAGGTGGA AGGGACTTGC CTTGTCTCAG ATGAGACTTT GGACTTGGAC TTTTGAGTTA AGACTTTGGG 005520
005521 GGACAGTTGG AAGGGCATTA TTGTGTTTTG AAATGGGAGG ACATGAGATT GGGGAGGGGC CAGGGGCAGA ATGATAATGG 005600
005601 TTTGGCTGTT TCTCCACCCA AATCTCATCT TGAATTGTAA TCCCCATAAT CCCCATATAT CGAGGGAGGG ACATGTTGGG 005680
005681 AGGTGACTGG ATCTTAGGGG TGGTTTCCCC CAGTTGTTCT CATAGTAATG AGTTCTCACA AGATCTGATG GTTTTATAAG 005760
005761 GCAGTTTTCC CTGCTCTTGC TCGCTCTGTC TTGCCTGCCG CCCTGTAAGA CGTGCCTCTT CCCCTTCTGC CATAATGGTA 005840
005841 AGTTCCTTGA GGCCTCCCCA GCCATGCAGA GCCATGAGTC AATTAAACCT CTTTTCTTTA TAAATTACCC AGTCTCGGGT 005920
005921 AGTATCTTTA CAGCAGTGAG AGAACAGACT AAGACAATCA GCTTCTATGT TGTTGGCAGT TTTACCATGA GCATGGATTC 006000
006001 CTATATTCCT TCTGAAATTT TCTTTAAAAG TGTAAGCTTA TATAGAAAGT ATATTCGACA CTCACAACCC TTCCCAGCCA 006080
006081 TAAAAGACAG TGGGGTGTGA GTGTGTGGGA TGGGATGCAG CAATGGCAGC CCAGTAACAA CAGCAGTGCG TGCCGGGAAC 006160
006161 AGCTCAGCAG CAGGGCAGGT CAGGGCTAAC CCAGTTAACT CAATGCAGGC TCCCTACACC AAGTGATTTG GTTTGCAAAT 006240
006241 AAATATTATT TGTTTCTGTT TTAATGTGTA AACAGAGCAC CTGAATTACA CAGTAATGTA ACTCTGAAAA TTGCTAAATT 006320
006321 TC
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