Difference between revisions of "LINC00668"

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===Characteristics ===
 
===Characteristics ===
−
[[File:Functional domains of 7SK RNA..png|right|thumb|Functional domains of 7SK RNA([https://www.ncbi.nlm.nih.gov/pubmed/19246988 (Diribarne 2009)])]]
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[[File:Relative LINC00668 expression in OSCC tissues and cell lines, and its clinical significance.jpg|right|thumb|Relative LINC00668 expression in OSCC tissues and cell lines, and its clinical significance]]
  
 
LINC00668 (NR_034100) is a 1751-bp lncRNA that maps to chromosome 18p11.31<ref name="ref1" />.
 
LINC00668 (NR_034100) is a 1751-bp lncRNA that maps to chromosome 18p11.31<ref name="ref1" />.
  
 
===Expression===
 
===Expression===
 +
LINC00668 is over-expressed in OSCC patients, OSCC tissues and cell lines.
  
 
===Regulation===
 
===Regulation===
 +
Please input regulation information here.
  
 
===Function===
 
===Function===
−
[[File:Model of hLarp7 recognition of the 7SK.png|right|thumb|Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP([https://www.ncbi.nlm.nih.gov/pubmed/29946027 (Eichhorn 2018)])]]
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[[File:LINC00668 is a direct target of miR-297.jpg|right|thumb|LINC00668 is a direct target of miR-297]]
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LINC00668 up-regulated the miR-297 target gene VEGFA by competitively ‘spongeing' miR-297 and then promoted the proliferation of OSCC cells. LINC00668 may function as a part of the ‘competitive endogenous RNA (ceRNA)' network<ref name="ref1" />.
  
 
===Disease===
 
===Disease===
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colon adenocarcinoma <ref name="ref1" />
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Oral squamous cell carcinoma (OSCC)  <ref name="ref1" />
  
 
===Evolution===
 
===Evolution===

Latest revision as of 03:38, 12 August 2019

Annotated Information

Name

Approved symbol: LINC00668

Approved name: long intergenic non-protein coding RNA 668

HGNC ID: HGNC:44328

RefSeq ID: NR_034100

Ensembl ID: ENSG00000265933

LncBook ID: HSALNT0247515

Chromosome

18p11.31

Characteristics

Relative LINC00668 expression in OSCC tissues and cell lines, and its clinical significance

LINC00668 (NR_034100) is a 1751-bp lncRNA that maps to chromosome 18p11.31[1].

Expression

LINC00668 is over-expressed in OSCC patients, OSCC tissues and cell lines.

Regulation

Please input regulation information here.

Function

LINC00668 is a direct target of miR-297

LINC00668 up-regulated the miR-297 target gene VEGFA by competitively ‘spongeing' miR-297 and then promoted the proliferation of OSCC cells. LINC00668 may function as a part of the ‘competitive endogenous RNA (ceRNA)' network[1].

Disease

Oral squamous cell carcinoma (OSCC) [1]

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM), School & Hospital of Stomatology, Wuhan University, Luoyu Rd. 237, Wuhan 430079, People's Republic of China.

References

  1. ↑ 1.0 1.1 1.2 Zhang CZ. Long intergenic non-coding RNA 668 regulates VEGFA signaling through inhibition of miR-297 in oral squamous cell carcinoma[J]. Biochem Biophys Res Commun, 2017, 489: 404-412.

Sequence

>gi|300795666|ref|NR_034100.1| Homo sapiens long intergenic non-protein coding RNA 668 (LINC00668), long non-coding RNA

000001 GGGGCGGCCT GGGACTCGGG GGCGGGGTCA GTCATATAAG GCTGTGCCCA GCGCTTTTGG AAGCAGTAAG TCCAGCCCGA 000080
000081 GGCTAAGGAG GTGTTAACCA CCGAAGGGAG GTAGAATGTT TTTCCCCACC AGAGGAGGCA GCGACCACGT CTCCTCTATG 000160
000161 GAGGCATTCA AGAGCCGTCC AGCTGAAGCA GCATCACTGT CTGAGCTCGG AAGGCACAAT CCACATAGGT CTGCATGGTC 000240
000241 CACCGAGCTG CATACCCACG GGGCCAGCGG GAGGTGGGCA GCTGCTGGGC TCTCTTCTGA AGCAGACAGG ATCTCACTCT 000320
000321 GTTGCTGAGG CTGGATCACA GCTCCCTGCA ACCTTGAACT CTCCCTCAAG CAATTCTCCC CACTCTGCCT TCCAAAGCAC 000400
000401 TAGCATTATA GGCCTAAGCC ACCACTCCCA TCCACTGTAG TGTAAACTGT CTCCTTCAAT GTTTCCAATA GTTGCGGAGC 000480
000481 AGATCAGATA AGGGTTCTTC CTGTCTGTTG CTTCAAGTTT CATTCTCTCT TTAAACAATA CAAGGTTGGC TTCCATGGTT 000560
000561 CCTTCTTAAA GAATGTTGAA GGTGTGTCTT CAGATTCATT TAGTGTTCGT GGAACCCCAG GGAAAGCTGA TGTAAAAACC 000640
000641 TCTTTTTTCT CCCATATGTC TCAAAAAGTT GTATTTTCTG GGTCCAAGGG ATCTGCAAGC CTCCTAAAGG CATTTCCATT 000720
000721 GTCACTACCA CCAGGTGTGA ACTGTAATCT GGCACGTATA GTTCCAAGAA CTGTCATAAT AGATGCTGAA GAAACATTGT 000800
000801 GAAGTTAACT CGCTGTTACC AACTGTGAAG TCATTAGCTA GAGGAATCTT GGGCGGTCTG AAATCTGAGA TACTGTGGAA 000880
000881 AGAACAGAAA GATCCTGTAT CTTTCCTATA ATTGTTCTAC TGGAAGTTGT CATTTTACAC AGGAGACATT CTGTTTTATT 000960
000961 TATTTTCTTT TGAGACAGGG TCTCACTCTG TCGCCCAGGC TGGAGTGCAG TGTTGTTACC ACAGGTCACT GGTGCCTCCA 001040
001041 CTGCCTGAGG ACTGCTCAAG CAATCCTCCT GCCTCAGTCC CCTGAGGAGC TGGGGCCACA GGCCTGCACC ACCATGCCTG 001120
001121 GCTAATTATT TTTATTTGTA GAGACAAAGT CTATCTTGCC TAGGCTGATC TCGAACTCCT GGGCTCAAGT AATCCTCCCG 001200
001201 CGGTGGCTTC TCAAAGTGCT TGGGATTACA GATGGTCTTG CTCTGTCACC CAGTCTGGAA TGCAGTGGTG CCATCATAGC 001280
001281 TCACTACAGC CTGAGCTGTA CTGAGCTCGA GGGATCTTCC CGTCTCCGCC TCCTAAGCAG CTGGGACTAC AGGTAATGGA 001360
001361 AGTGGGCAGA GAATGATCCT TTCCCTAGGC TCCAGTGTGT AAGAATTAAA GAAAGAGGAA AGAAACACAA TGGCTTGATG 001440
001441 GTCGAGGACA GGTTTATTTT AAAGAAAACA AACCCAAGAG TGGCTTCTGG CTGAGTTAGA TCAGAGAAGA GAAGTGATTT 001520
001521 TCTTGAAATG CATGAGGCTG GAAAGGGAGC TGGCACTTAA AGTGGCGGTG TTTGTCCGAG AGGATGGTGC TCCTGCTCTG 001600
001601 TCACAGTGGG CATGGGGATT CAGGCCACTG CCACCGAATT TCAAGAGCCC AAGCACAGAG CCCAGAACTA AATTGTGAGG 001680
001681 GTTTAAAAAA AAAAAAAGCT TTATTGAAGT ATAATTGACA TACAATAAAC TTGAATATTT AAAGTGTACA A
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