Difference between revisions of "CERNA1"
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==Annotated Information== | ==Annotated Information== | ||
| + | [[File:LncRNA CERNA1 was upregulated by ABO.jpg|right|thumb|400px|'''LncRNA CERNA1 was upregulated by ABO.'''<ref name="ref1" />]] | ||
| + | [[File:LncRNA CERNA1 regulated the expression of miR-4707-5p and miR-4767 by directly binding with them.jpg|right|thumb|400px|'''LncRNA CERNA1 regulated the expression of miR-4707-5p and miR-4767 by directly binding with them.'''<ref name="ref1" />]] | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
CERNA1 (competing endogenous lncRNA 1 for miR-4707-5p and miR-4767) | CERNA1 (competing endogenous lncRNA 1 for miR-4707-5p and miR-4767) | ||
| − | |||
| − | |||
===Synonyms=== | ===Synonyms=== | ||
LOC100129973 | LOC100129973 | ||
| Line 10: | Line 10: | ||
===RefSeq(supplied by NCBI)=== | ===RefSeq(supplied by NCBI)=== | ||
NR_102751 | NR_102751 | ||
| − | === | + | ===LncBook transcript ID=== |
| − | + | HSALNT0288916 | |
===Characteristics=== | ===Characteristics=== | ||
CERNA1 is a 1520bp length validated long noncoding RNA. It locates in chromosome 15 (21.1) and antisense to guanine nucleotide binding protein,beta 5 (GNB5) and myosin VC (MYO5C). <ref name="ref1" /> | CERNA1 is a 1520bp length validated long noncoding RNA. It locates in chromosome 15 (21.1) and antisense to guanine nucleotide binding protein,beta 5 (GNB5) and myosin VC (MYO5C). <ref name="ref1" /> | ||
CERNA1 is only found in Homo sapiens.<ref name="ref1" /> | CERNA1 is only found in Homo sapiens.<ref name="ref1" /> | ||
| + | ===Function=== | ||
| + | CERNA1 suppresses apoptosis by targeting miR-4707-5p and miR-4767 in vascular endothelial cells<ref name="ref1" />. | ||
| + | |||
| + | LOC100129973 widely co-expressed with differentially expressed mRNAs and may be associated with CRC progression<ref name="ref2" />. | ||
| + | ===Regulation=== | ||
| + | - | ||
===Expression=== | ===Expression=== | ||
| − | CERNA1 wis upregulated by ABO treatment in a dose- and time -dependent manner. | + | CERNA1 wis upregulated by ABO (6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine) treatment in a dose- and time-dependent manner<ref name="ref1" />. |
| + | |||
| + | LOC100129973 is up-regulated in Colorectal cancer (CRC)<ref name="ref2" />. | ||
===Disease=== | ===Disease=== | ||
| − | + | Cardiovascular disease<ref name="ref1" /> | |
| − | === | + | |
| − | + | Colorectal cancer (CRC)<ref name="ref2" /> | |
| + | ===Sequence=== | ||
| + | >NR_102751.1 Homo sapiens competing endogenous lncRNA 1 for miR-4707-5p and miR-4767 (CERNA1), long non-coding RNA | ||
| + | <dnaseq>TGCTGCGCCTGAGCCCCAAGACCCCGCACCTGGGCGCGCGCTCTGGCGCAGTGCCTGGTGCGATGTCCGC | ||
| + | GTCAGCCTCTCTCCTCCGGGAGAGGCAGGGAGTGTGACGCCCATTTTACCAGCGGGCAAACTGTGGCTTA | ||
| + | GGGATGCTGGGTGATTTGCCCGAGGACGCACACAGAGGGAAGGGCCAAGCCGGGATTCCAACTCGGGACT | ||
| + | CCCCGCTTCTGGGGAGACCGGTGAGGCCCCCGCGACATGGCCCTCCCATCCCCAAGCCTCTCGTGCAGAT | ||
| + | CTCCGCTCTGTGGGACTTGATTGCGGGCTGCGGGCCCGTGGCTCCTGCAGGCAGAGAGAGGACGGGAGAG | ||
| + | GAGACGGCTACGAGGCTTGGCCGCAGAGAATGAGAAGGCAGATCAAAGTTACAGATGCTGCGAGAACATC | ||
| + | GCCAAGCAGAATCTTGGGTGCTGTCCCCACCTCTCTGTACCTGCTCCCTCCCAGAGAAGCCAGCCTCCAC | ||
| + | TTGCTGTCCCGGGCCTTCTCTATCTGAGAAAAGTTGAAGGAGCACATGTCCTTGCGCAGGAAGAGGCTGT | ||
| + | TCAGCGTGACCGCCCCGATCAAGAAGAAGAGCTGCTTCACCGCCTGCCTCACAAGCTCGGGGTCCAGGCC | ||
| + | GTTCTGGCACATGGTGGTGTAAAAGTAGCTCAGCTGTTGCAGGACGGAGGTCATGGTGTAGCCGTCCGTG | ||
| + | TCGTCTATGCTAGAGGAGCGCTTCCGGAAGCCTGTGGGCTTCAGGCCGGAAATGCCCTGCAGGCTCTCAT | ||
| + | ACTCCAGCATTCCCGGAACTGCGGAGAGACAGGGAGGCTGTGCTGACACGCCAGGAGACACACGCGGAAC | ||
| + | GTTCCCGACGCTCTTCGGTTTGTTTCAGGAGATGGGACATTTTTCTACAAGAGTCAGTGGATGTACTTAT | ||
| + | GATAGAGAAAGCAAAAGAATCAAGGGTTTGGGACACCAGGGTGTGTGTCAGGGTTAGGGATGGACGGCTG | ||
| + | TTTCCAGCGGGGCTGCAGCTCCTCTTGTAGGTTTGAAGCAGCACGTTTTTCAGCTTCACAGGAAAGAAAG | ||
| + | CTGCTTAGCATGACAAATCATGGCCTGGGCATTAAAGCCTAAAGTATTTAAATTTCAGGAAATTAAGGAA | ||
| + | AGTATACAAGAATTCGAATGGGGCTTTAGGATTTCAAAAATACTTGGCTACGCCAAGAAGTAGAAGTACC | ||
| + | ACATAAATAGCAGTAGTAGAAGTTTCCCCAAGTTTTTTCCTTCAGGATAAATCATCCTTATATAAAGAAA | ||
| + | ACTACCAACAGCGTACTATTATTTATGGAATCATTATAAGCAAGCAAAGAATTAAAAGGCAGATATCTAC | ||
| + | ATGATTATATTTCCTTGGCTTTTTAAACAATGTTACACATAATCACACATTACACATACCAAGTTTATGT | ||
| + | TTTAAAAAGTCTTAATGTTACTATAAATATTTTTTGGTCATCCATTCTCTTCTTACCTATTATCGGTTGG | ||
| + | ATATTCTTTTCCATTATGATAATAAATTGATGATATATTCGTATAGCCAC</dnaseq> | ||
| + | |||
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
* Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China. | * Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China. | ||
| Line 29: | Line 62: | ||
<ref name="ref1">Lu, W., et al., Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells. Sci Rep, 2016. 6: p. 21620. | <ref name="ref1">Lu, W., et al., Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells. Sci Rep, 2016. 6: p. 21620. | ||
</ref>(1) | </ref>(1) | ||
| + | <ref name="ref2"> | ||
| + | Zhu H, Yu J, Zhu H, et al. Identification of key lncRNAs in colorectal cancer progression based on associated protein–protein interaction analysis[J]. World journal of surgical oncology, 2017, 15(1): 153. | ||
| + | </ref>(2) | ||
</references> | </references> | ||
Latest revision as of 04:01, 12 August 2019
Contents
Annotated Information
LncRNA CERNA1 was upregulated by ABO.[1]
LncRNA CERNA1 regulated the expression of miR-4707-5p and miR-4767 by directly binding with them.[1]
Approved Symbol
CERNA1 (competing endogenous lncRNA 1 for miR-4707-5p and miR-4767)
Synonyms
LOC100129973
Chromosome
15q21.2
RefSeq(supplied by NCBI)
NR_102751
LncBook transcript ID
HSALNT0288916
Characteristics
CERNA1 is a 1520bp length validated long noncoding RNA. It locates in chromosome 15 (21.1) and antisense to guanine nucleotide binding protein,beta 5 (GNB5) and myosin VC (MYO5C). [1] CERNA1 is only found in Homo sapiens.[1]
Function
CERNA1 suppresses apoptosis by targeting miR-4707-5p and miR-4767 in vascular endothelial cells[1].
LOC100129973 widely co-expressed with differentially expressed mRNAs and may be associated with CRC progression[2].
Regulation
-
Expression
CERNA1 wis upregulated by ABO (6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine) treatment in a dose- and time-dependent manner[1].
LOC100129973 is up-regulated in Colorectal cancer (CRC)[2].
Disease
Cardiovascular disease[1]
Colorectal cancer (CRC)[2]
Sequence
>NR_102751.1 Homo sapiens competing endogenous lncRNA 1 for miR-4707-5p and miR-4767 (CERNA1), long non-coding RNA
000001 TGCTGCGCCT GAGCCCCAAG ACCCCGCACC TGGGCGCGCG CTCTGGCGCA GTGCCTGGTG CGATGTCCGC GTCAGCCTCT 000080
000081 CTCCTCCGGG AGAGGCAGGG AGTGTGACGC CCATTTTACC AGCGGGCAAA CTGTGGCTTA GGGATGCTGG GTGATTTGCC 000160
000161 CGAGGACGCA CACAGAGGGA AGGGCCAAGC CGGGATTCCA ACTCGGGACT CCCCGCTTCT GGGGAGACCG GTGAGGCCCC 000240
000241 CGCGACATGG CCCTCCCATC CCCAAGCCTC TCGTGCAGAT CTCCGCTCTG TGGGACTTGA TTGCGGGCTG CGGGCCCGTG 000320
000321 GCTCCTGCAG GCAGAGAGAG GACGGGAGAG GAGACGGCTA CGAGGCTTGG CCGCAGAGAA TGAGAAGGCA GATCAAAGTT 000400
000401 ACAGATGCTG CGAGAACATC GCCAAGCAGA ATCTTGGGTG CTGTCCCCAC CTCTCTGTAC CTGCTCCCTC CCAGAGAAGC 000480
000481 CAGCCTCCAC TTGCTGTCCC GGGCCTTCTC TATCTGAGAA AAGTTGAAGG AGCACATGTC CTTGCGCAGG AAGAGGCTGT 000560
000561 TCAGCGTGAC CGCCCCGATC AAGAAGAAGA GCTGCTTCAC CGCCTGCCTC ACAAGCTCGG GGTCCAGGCC GTTCTGGCAC 000640
000641 ATGGTGGTGT AAAAGTAGCT CAGCTGTTGC AGGACGGAGG TCATGGTGTA GCCGTCCGTG TCGTCTATGC TAGAGGAGCG 000720
000721 CTTCCGGAAG CCTGTGGGCT TCAGGCCGGA AATGCCCTGC AGGCTCTCAT ACTCCAGCAT TCCCGGAACT GCGGAGAGAC 000800
000801 AGGGAGGCTG TGCTGACACG CCAGGAGACA CACGCGGAAC GTTCCCGACG CTCTTCGGTT TGTTTCAGGA GATGGGACAT 000880
000881 TTTTCTACAA GAGTCAGTGG ATGTACTTAT GATAGAGAAA GCAAAAGAAT CAAGGGTTTG GGACACCAGG GTGTGTGTCA 000960
000961 GGGTTAGGGA TGGACGGCTG TTTCCAGCGG GGCTGCAGCT CCTCTTGTAG GTTTGAAGCA GCACGTTTTT CAGCTTCACA 001040
001041 GGAAAGAAAG CTGCTTAGCA TGACAAATCA TGGCCTGGGC ATTAAAGCCT AAAGTATTTA AATTTCAGGA AATTAAGGAA 001120
001121 AGTATACAAG AATTCGAATG GGGCTTTAGG ATTTCAAAAA TACTTGGCTA CGCCAAGAAG TAGAAGTACC ACATAAATAG 001200
001201 CAGTAGTAGA AGTTTCCCCA AGTTTTTTCC TTCAGGATAA ATCATCCTTA TATAAAGAAA ACTACCAACA GCGTACTATT 001280
001281 ATTTATGGAA TCATTATAAG CAAGCAAAGA ATTAAAAGGC AGATATCTAC ATGATTATAT TTCCTTGGCT TTTTAAACAA 001360
001361 TGTTACACAT AATCACACAT TACACATACC AAGTTTATGT TTTAAAAAGT CTTAATGTTA CTATAAATAT TTTTTGGTCA 001440
001441 TCCATTCTCT TCTTACCTAT TATCGGTTGG ATATTCTTTT CCATTATGAT AATAAATTGA TGATATATTC GTATAGCCAC 001520
000081 CTCCTCCGGG AGAGGCAGGG AGTGTGACGC CCATTTTACC AGCGGGCAAA CTGTGGCTTA GGGATGCTGG GTGATTTGCC 000160
000161 CGAGGACGCA CACAGAGGGA AGGGCCAAGC CGGGATTCCA ACTCGGGACT CCCCGCTTCT GGGGAGACCG GTGAGGCCCC 000240
000241 CGCGACATGG CCCTCCCATC CCCAAGCCTC TCGTGCAGAT CTCCGCTCTG TGGGACTTGA TTGCGGGCTG CGGGCCCGTG 000320
000321 GCTCCTGCAG GCAGAGAGAG GACGGGAGAG GAGACGGCTA CGAGGCTTGG CCGCAGAGAA TGAGAAGGCA GATCAAAGTT 000400
000401 ACAGATGCTG CGAGAACATC GCCAAGCAGA ATCTTGGGTG CTGTCCCCAC CTCTCTGTAC CTGCTCCCTC CCAGAGAAGC 000480
000481 CAGCCTCCAC TTGCTGTCCC GGGCCTTCTC TATCTGAGAA AAGTTGAAGG AGCACATGTC CTTGCGCAGG AAGAGGCTGT 000560
000561 TCAGCGTGAC CGCCCCGATC AAGAAGAAGA GCTGCTTCAC CGCCTGCCTC ACAAGCTCGG GGTCCAGGCC GTTCTGGCAC 000640
000641 ATGGTGGTGT AAAAGTAGCT CAGCTGTTGC AGGACGGAGG TCATGGTGTA GCCGTCCGTG TCGTCTATGC TAGAGGAGCG 000720
000721 CTTCCGGAAG CCTGTGGGCT TCAGGCCGGA AATGCCCTGC AGGCTCTCAT ACTCCAGCAT TCCCGGAACT GCGGAGAGAC 000800
000801 AGGGAGGCTG TGCTGACACG CCAGGAGACA CACGCGGAAC GTTCCCGACG CTCTTCGGTT TGTTTCAGGA GATGGGACAT 000880
000881 TTTTCTACAA GAGTCAGTGG ATGTACTTAT GATAGAGAAA GCAAAAGAAT CAAGGGTTTG GGACACCAGG GTGTGTGTCA 000960
000961 GGGTTAGGGA TGGACGGCTG TTTCCAGCGG GGCTGCAGCT CCTCTTGTAG GTTTGAAGCA GCACGTTTTT CAGCTTCACA 001040
001041 GGAAAGAAAG CTGCTTAGCA TGACAAATCA TGGCCTGGGC ATTAAAGCCT AAAGTATTTA AATTTCAGGA AATTAAGGAA 001120
001121 AGTATACAAG AATTCGAATG GGGCTTTAGG ATTTCAAAAA TACTTGGCTA CGCCAAGAAG TAGAAGTACC ACATAAATAG 001200
001201 CAGTAGTAGA AGTTTCCCCA AGTTTTTTCC TTCAGGATAA ATCATCCTTA TATAAAGAAA ACTACCAACA GCGTACTATT 001280
001281 ATTTATGGAA TCATTATAAG CAAGCAAAGA ATTAAAAGGC AGATATCTAC ATGATTATAT TTCCTTGGCT TTTTAAACAA 001360
001361 TGTTACACAT AATCACACAT TACACATACC AAGTTTATGT TTTAAAAAGT CTTAATGTTA CTATAAATAT TTTTTGGTCA 001440
001441 TCCATTCTCT TCTTACCTAT TATCGGTTGG ATATTCTTTT CCATTATGAT AATAAATTGA TGATATATTC GTATAGCCAC 001520
Labs working on this lncRNA
- Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China.
- Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
- The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, 250012, China.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Lu, W., et al., Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells. Sci Rep, 2016. 6: p. 21620.
- ↑ 2.0 2.1 2.2 Zhu H, Yu J, Zhu H, et al. Identification of key lncRNAs in colorectal cancer progression based on associated protein–protein interaction analysis[J]. World journal of surgical oncology, 2017, 15(1): 153.
