Difference between revisions of "LINC00598"

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(Created page with "==Annotated Information== ===Approved Symbol=== LINC00598 ===Approved Name=== long intergenic non-protein coding RNA 598 ===Previous Symbols=== _ ===Synonyms=== TTL ===Chromos...")
 
 
(One intermediate revision by the same user not shown)
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==Annotated Information==
 
==Annotated Information==
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===Approved Symbol===
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===Name===
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LINC00598
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Approved Symbol: LINC00598
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===Approved Name===
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−
long intergenic non-protein coding RNA 598
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Approved Name: long intergenic non-protein coding RNA 598
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===Previous Symbols===
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−
_
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Previous Symbols: -
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===Synonyms===
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−
TTL
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Synonyms: TTL, lncFOXO1
 +
 
 +
RefSeq ID: NR_024505
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 +
Ensembl ID: ENSG00000215483
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 +
LncBook transcript ID: HSALNT0200443
 
===Chromosome===
 
===Chromosome===
 
13q14.11
 
13q14.11
−
===RefSeq ID===
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[[File:Lncfoxo1-fun.png|right|thumb|400px|Overexpression of lncFOXO1 inhibits cell proliferation, colony formation, and induces G0/G1 cell cycle arrest and apoptosis in breast cancer cells<ref name="ref1" />.]]
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NR_024505
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===OMIM ID===
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[[File:Lncfoxo1-exp.png|right|thumb|400px|Downregulation of lncFOXO1 expression in human breast cancer tissues<ref name="ref1" />.]]
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_
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===Characteristics===
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===Ensembl ID===
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A total length of 683 nt of lncFOXO1 transcript was determined by a RACE assay. LncFOXO1 was mainly localized in the nuclei of breast cancer cells <ref name="ref1" />.
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ENSG00000215483
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===Function===
 +
 
 +
 
 +
* LncFOXO1 suppresses the growth of human breast cancer cells through association with BAP1. Mechanistically, lncFOXO1 suppressed the growth of breast cancer by increasing FOXO1 transcription. Moreover,lncFOXO1 associated with BRCA-1-associated protein 1 (BAP1) and regulates its binding and the level of mono-ubiquitinated H2A at K119 (ubH2AK119) at FOXO1 promoter<ref name="ref1" />.
 +
 
 +
===Regulation===
 +
-
 +
===Diseases===
 +
Breast cancer<ref name="ref1" />.
 +
 
 +
===Expression===
 +
lncFOXO1 is significantly decreased in breast cancer tissues and cell lines and downregulation of lncFOXO1 expression associates with poorer overall survival<ref name="ref1" />.
 +
 
 +
{| class='wikitable' style="text-align:center"
 +
|-
 +
! | Experiment
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! | Forward primer
 +
! | Reverse primer
 +
|-
 +
| rowspan="1"|Quantitative real-time PCR
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| | 5'-CGATGTGCTGGAGTGTATGT- 3'
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| | 5'-GCAGGATGGCACTACTGATAA- 3'<ref name="ref1" />
 +
|}
 +
 
 +
===Evolution===
 +
-
 
===pubmed IDs===
 
===pubmed IDs===
−
12764377
+
12764377, 28339037
 
===Sequence===
 
===Sequence===
 
>gi|213688418|ref|NR_024505.1| Homo sapiens long intergenic non-protein coding RNA 598 (LINC00598), transcript variant TTL-T, long non-coding RNA
 
>gi|213688418|ref|NR_024505.1| Homo sapiens long intergenic non-protein coding RNA 598 (LINC00598), transcript variant TTL-T, long non-coding RNA
 
<dnaseq>CGCTGTAGAGCTCCGATGATGGCTGTTGGCCGAATGGATGAATGGCTTCATTAACTTCACTGCAACACGCAGGAGTCCTTGATCTCCCCCCTTGAAAGGCTGGAGCACAGTGGCATGATCTCGGCTAACTGCAACCTCTGCCTGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGCAAACAATGGACTATTGACTAAGCTTTCAGAGCTGTGGGTGTTCTCAGAGGGAGGCCAGCCAGAACACCAGCATCTCCGGCTTTTCTTCCAACTCCCAAGTTGGAGCTCCATCTATCAGAAATATGAAACCCTGGAATCTTCCTCCTCCTCACTTCTCTGCCTTAAGATCCTAGTCCACTGCCTGGAACATGGAAGATGCTCCATAATTGTTTGCTGAAGGAACGAGTGATAACCAGAGAAGCCAGCTCCTGCTTCCTGATTAAGGCATGCAGTCAGGCCAGTGGGGAAATGGGCCTCATGGTGGAGCTTGCCTCTGCTGGAAGACTGACGGAGCCAGGGCTCTGCCTGCCACAATTCATGAGCTGGCCAGAGGTCTTTGGATTCCTCCCAGTCATTGCTGAGATGAGTGAGGATTGTTTCAGAAAATCAGGCCTCCTCCTGGGGAATGTGCCTCAGCTTCTGGCTGCATCAGTGATTTGGACACCCCTTAAGGACAAAGAGCGTGGTTGGGAGAAGAGCGCTTTCCACCCCTCTCCTTCAGGACCATCCTGGATGCAGCTGCAACTCTGCTCTTGGCTGTCCTATGGCTGGCAATAGCTTTCTTGCTCTCTGGCAGGCAAAAAGCAGGGTGTGTGTGTGTGTGTGTGCATGCGTGCACGTGCTCATGTGTGCATGCACTGGAAAGCTAAGGCTGAGGCATCGAATGACAAGATCCCTGAAGTAAAAGGCTCCACAGCTGCTTACCCAACCCCTAATTTGCTGGGGCTGGGCTCCTTCTAATGGGCTGCCAGACCCTGGTAGGCACAAGGAGACTGGCTGTATATGTCTCGTGTCCCCTGGGCGACTGTCCCAGTGAGCAAGGACACCACCAACCTTCTTCCCCCCTACACCCTCCATAGGACAGTGAGATCCTGCATTGGATTATGCATGAGGTGTATACACTCTGCTTGTACGTATGTATGGAAGAAAGGATTTTGGCTTGAAACATTTTTTTTATTGGCAGAGACAGCACTTCTCTTAAAGGAAATGGCGGAATTTGCCAAACTAAGCCTCCAGAAGAAAATATAACGGAGAGTGTAAAAGAAATCCATGTTCAAACATTGGCAAGTGTGAAACATTCAAGATTTTTGTGTGAACATCACATTGTGGGAGCAAAATTAAATTAAGCTGGTCTCTGGCAAGCATTGGAATGAAAGCAGAACTGGAGCAAGCGGATGGTGCTTGGGCATTTTTTGCAAGAAGCCAAACAGAGCATAATCAGATGACAACCAGGGATCCCAAGGGCTGGGTTCTTTTCTTCATCTCATTAACACACAAGAACTTAACTGCTTTGGGTCCGGAGGGTCCCAAGGAAGTGCCAAAAGAACCTGAACTTTCTTCACCTCCACAACTCAATGACAGGCAGAGAAGGAATGAATTTCATTCAAAAAATATTTATTGAGCATCCTCAGAATATTTATTGTGCAAACTACTGTTCCAGGCACCAAAGGAGGGGATGGTCCCAGCTCCTTTATGGAGTCTGCAGTCCACAGACTTGAACTCAACTAACTAGAAGGAAAGGCAGCTCAGAGCAAGTGCCCTGCTGGAGATTGAAGCAAAGTGCCAGAGAACGTGGGGGTCATTCAAGAATGAGGTTGGAAGAGATCATTCTCCTGTTTGCAAATGAGAAACAAGTATAGGTGTGAAGAGACCTGTCCACAGCCATTCAACAAATGAAAAGTCCAATCGAAGATGGGACCTGATTTCTTACACCCCAGGTATCTGCTCATCATCTTGGGTAAGACCACAGGGACCACCAAGACACCCAGAAGAGACACTTGATTGTTTCCTGGATGTTCCAGTTTTGGGGCCCATAGATATATGCCATTTACTTTACATGCTTTCTAAAAAA</dnaseq>
 
<dnaseq>CGCTGTAGAGCTCCGATGATGGCTGTTGGCCGAATGGATGAATGGCTTCATTAACTTCACTGCAACACGCAGGAGTCCTTGATCTCCCCCCTTGAAAGGCTGGAGCACAGTGGCATGATCTCGGCTAACTGCAACCTCTGCCTGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGCAAACAATGGACTATTGACTAAGCTTTCAGAGCTGTGGGTGTTCTCAGAGGGAGGCCAGCCAGAACACCAGCATCTCCGGCTTTTCTTCCAACTCCCAAGTTGGAGCTCCATCTATCAGAAATATGAAACCCTGGAATCTTCCTCCTCCTCACTTCTCTGCCTTAAGATCCTAGTCCACTGCCTGGAACATGGAAGATGCTCCATAATTGTTTGCTGAAGGAACGAGTGATAACCAGAGAAGCCAGCTCCTGCTTCCTGATTAAGGCATGCAGTCAGGCCAGTGGGGAAATGGGCCTCATGGTGGAGCTTGCCTCTGCTGGAAGACTGACGGAGCCAGGGCTCTGCCTGCCACAATTCATGAGCTGGCCAGAGGTCTTTGGATTCCTCCCAGTCATTGCTGAGATGAGTGAGGATTGTTTCAGAAAATCAGGCCTCCTCCTGGGGAATGTGCCTCAGCTTCTGGCTGCATCAGTGATTTGGACACCCCTTAAGGACAAAGAGCGTGGTTGGGAGAAGAGCGCTTTCCACCCCTCTCCTTCAGGACCATCCTGGATGCAGCTGCAACTCTGCTCTTGGCTGTCCTATGGCTGGCAATAGCTTTCTTGCTCTCTGGCAGGCAAAAAGCAGGGTGTGTGTGTGTGTGTGTGCATGCGTGCACGTGCTCATGTGTGCATGCACTGGAAAGCTAAGGCTGAGGCATCGAATGACAAGATCCCTGAAGTAAAAGGCTCCACAGCTGCTTACCCAACCCCTAATTTGCTGGGGCTGGGCTCCTTCTAATGGGCTGCCAGACCCTGGTAGGCACAAGGAGACTGGCTGTATATGTCTCGTGTCCCCTGGGCGACTGTCCCAGTGAGCAAGGACACCACCAACCTTCTTCCCCCCTACACCCTCCATAGGACAGTGAGATCCTGCATTGGATTATGCATGAGGTGTATACACTCTGCTTGTACGTATGTATGGAAGAAAGGATTTTGGCTTGAAACATTTTTTTTATTGGCAGAGACAGCACTTCTCTTAAAGGAAATGGCGGAATTTGCCAAACTAAGCCTCCAGAAGAAAATATAACGGAGAGTGTAAAAGAAATCCATGTTCAAACATTGGCAAGTGTGAAACATTCAAGATTTTTGTGTGAACATCACATTGTGGGAGCAAAATTAAATTAAGCTGGTCTCTGGCAAGCATTGGAATGAAAGCAGAACTGGAGCAAGCGGATGGTGCTTGGGCATTTTTTGCAAGAAGCCAAACAGAGCATAATCAGATGACAACCAGGGATCCCAAGGGCTGGGTTCTTTTCTTCATCTCATTAACACACAAGAACTTAACTGCTTTGGGTCCGGAGGGTCCCAAGGAAGTGCCAAAAGAACCTGAACTTTCTTCACCTCCACAACTCAATGACAGGCAGAGAAGGAATGAATTTCATTCAAAAAATATTTATTGAGCATCCTCAGAATATTTATTGTGCAAACTACTGTTCCAGGCACCAAAGGAGGGGATGGTCCCAGCTCCTTTATGGAGTCTGCAGTCCACAGACTTGAACTCAACTAACTAGAAGGAAAGGCAGCTCAGAGCAAGTGCCCTGCTGGAGATTGAAGCAAAGTGCCAGAGAACGTGGGGGTCATTCAAGAATGAGGTTGGAAGAGATCATTCTCCTGTTTGCAAATGAGAAACAAGTATAGGTGTGAAGAGACCTGTCCACAGCCATTCAACAAATGAAAAGTCCAATCGAAGATGGGACCTGATTTCTTACACCCCAGGTATCTGCTCATCATCTTGGGTAAGACCACAGGGACCACCAAGACACCCAGAAGAGACACTTGATTGTTTCCTGGATGTTCCAGTTTTGGGGCCCATAGATATATGCCATTTACTTTACATGCTTTCTAAAAAA</dnaseq>
 +
==Labs working on this lncRNA==
 +
* Department of Gynecology, Cangzhou Central Hospital, Cangzhou, Heibei 061001, P.R. China.
 +
==References==
 +
<references>
 +
<ref name="ref1">
 +
Xi J, Feng J, Li Q, Li X, Zeng S. The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1. Int J Oncol. 2017 May;50(5):1663-1670.
 +
</ref>(1)
 +
</references>

Latest revision as of 08:32, 13 August 2019

Annotated Information

Name

Approved Symbol: LINC00598

Approved Name: long intergenic non-protein coding RNA 598

Previous Symbols: -

Synonyms: TTL, lncFOXO1

RefSeq ID: NR_024505

Ensembl ID: ENSG00000215483

LncBook transcript ID: HSALNT0200443

Chromosome

13q14.11

Overexpression of lncFOXO1 inhibits cell proliferation, colony formation, and induces G0/G1 cell cycle arrest and apoptosis in breast cancer cells[1].
Downregulation of lncFOXO1 expression in human breast cancer tissues[1].

Characteristics

A total length of 683 nt of lncFOXO1 transcript was determined by a RACE assay. LncFOXO1 was mainly localized in the nuclei of breast cancer cells [1].

Function

  • LncFOXO1 suppresses the growth of human breast cancer cells through association with BAP1. Mechanistically, lncFOXO1 suppressed the growth of breast cancer by increasing FOXO1 transcription. Moreover,lncFOXO1 associated with BRCA-1-associated protein 1 (BAP1) and regulates its binding and the level of mono-ubiquitinated H2A at K119 (ubH2AK119) at FOXO1 promoter[1].

Regulation

-

Diseases

Breast cancer[1].

Expression

lncFOXO1 is significantly decreased in breast cancer tissues and cell lines and downregulation of lncFOXO1 expression associates with poorer overall survival[1].

Experiment Forward primer Reverse primer
Quantitative real-time PCR 5'-CGATGTGCTGGAGTGTATGT- 3' 5'-GCAGGATGGCACTACTGATAA- 3'[1]

Evolution

-

pubmed IDs

12764377, 28339037

Sequence

>gi|213688418|ref|NR_024505.1| Homo sapiens long intergenic non-protein coding RNA 598 (LINC00598), transcript variant TTL-T, long non-coding RNA

000001 CGCTGTAGAG CTCCGATGAT GGCTGTTGGC CGAATGGATG AATGGCTTCA TTAACTTCAC TGCAACACGC AGGAGTCCTT 000080
000081 GATCTCCCCC CTTGAAAGGC TGGAGCACAG TGGCATGATC TCGGCTAACT GCAACCTCTG CCTGCCTCCC AGGTTCAAGC 000160
000161 AATTCTCCTG CCTCAGCCTC CCAAGTAGCT GGGATTACAG CAAACAATGG ACTATTGACT AAGCTTTCAG AGCTGTGGGT 000240
000241 GTTCTCAGAG GGAGGCCAGC CAGAACACCA GCATCTCCGG CTTTTCTTCC AACTCCCAAG TTGGAGCTCC ATCTATCAGA 000320
000321 AATATGAAAC CCTGGAATCT TCCTCCTCCT CACTTCTCTG CCTTAAGATC CTAGTCCACT GCCTGGAACA TGGAAGATGC 000400
000401 TCCATAATTG TTTGCTGAAG GAACGAGTGA TAACCAGAGA AGCCAGCTCC TGCTTCCTGA TTAAGGCATG CAGTCAGGCC 000480
000481 AGTGGGGAAA TGGGCCTCAT GGTGGAGCTT GCCTCTGCTG GAAGACTGAC GGAGCCAGGG CTCTGCCTGC CACAATTCAT 000560
000561 GAGCTGGCCA GAGGTCTTTG GATTCCTCCC AGTCATTGCT GAGATGAGTG AGGATTGTTT CAGAAAATCA GGCCTCCTCC 000640
000641 TGGGGAATGT GCCTCAGCTT CTGGCTGCAT CAGTGATTTG GACACCCCTT AAGGACAAAG AGCGTGGTTG GGAGAAGAGC 000720
000721 GCTTTCCACC CCTCTCCTTC AGGACCATCC TGGATGCAGC TGCAACTCTG CTCTTGGCTG TCCTATGGCT GGCAATAGCT 000800
000801 TTCTTGCTCT CTGGCAGGCA AAAAGCAGGG TGTGTGTGTG TGTGTGTGCA TGCGTGCACG TGCTCATGTG TGCATGCACT 000880
000881 GGAAAGCTAA GGCTGAGGCA TCGAATGACA AGATCCCTGA AGTAAAAGGC TCCACAGCTG CTTACCCAAC CCCTAATTTG 000960
000961 CTGGGGCTGG GCTCCTTCTA ATGGGCTGCC AGACCCTGGT AGGCACAAGG AGACTGGCTG TATATGTCTC GTGTCCCCTG 001040
001041 GGCGACTGTC CCAGTGAGCA AGGACACCAC CAACCTTCTT CCCCCCTACA CCCTCCATAG GACAGTGAGA TCCTGCATTG 001120
001121 GATTATGCAT GAGGTGTATA CACTCTGCTT GTACGTATGT ATGGAAGAAA GGATTTTGGC TTGAAACATT TTTTTTATTG 001200
001201 GCAGAGACAG CACTTCTCTT AAAGGAAATG GCGGAATTTG CCAAACTAAG CCTCCAGAAG AAAATATAAC GGAGAGTGTA 001280
001281 AAAGAAATCC ATGTTCAAAC ATTGGCAAGT GTGAAACATT CAAGATTTTT GTGTGAACAT CACATTGTGG GAGCAAAATT 001360
001361 AAATTAAGCT GGTCTCTGGC AAGCATTGGA ATGAAAGCAG AACTGGAGCA AGCGGATGGT GCTTGGGCAT TTTTTGCAAG 001440
001441 AAGCCAAACA GAGCATAATC AGATGACAAC CAGGGATCCC AAGGGCTGGG TTC<