Difference between revisions of "LINC00628"

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(Created page with "==Annotated Information== ===Approved Symbol=== LINC00628 ===Approved Name=== long intergenic non-protein coding RNA 628 ===Previous Symbols=== _ ===Synonyms=== _ ===Chromosom...")
 
 
(One intermediate revision by the same user not shown)
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==Annotated Information==
 
==Annotated Information==
−
===Approved Symbol===
+
===Name===
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LINC00628
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−
===Approved Name===
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Approved Symbol: LINC00628
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long intergenic non-protein coding RNA 628
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−
===Previous Symbols===
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Approved Name: long intergenic non-protein coding RNA 628
−
_
+
 
−
===Synonyms===
+
RefSeq ID: NR_027022
−
_
+
 
 +
LncBook transcript ID: HSALNT0020406
 +
 
 +
Ensembl ID: ENSG00000280924
 
===Chromosome===
 
===Chromosome===
 
1q32.1
 
1q32.1
−
===RefSeq ID===
+
 
−
NR_027022
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===Characteristics===
−
===OMIM ID===
+
LncRNA LINC00628 locates in the second intron of PLEKHA6 (pleckstrin homology domain-containing A6) in chromosome 1q32.1, the mature RNA of which is 1290bp and has a poly-A tail and is discovered in many tumor formations<ref name="ref1" />.
−
_
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===Function===
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===Ensembl ID===
+
 
−
ENSG00000280924
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* The overexpression of LINC00628 inhibited the proliferation, invasion and migration and promoted cell apoptosis in osteosarcoma cells through the inactivation of PI3K/Akt signaling pathway<ref name="ref1" />.
 +
 
 +
===Regulation===
 +
-
 +
===Diseases===
 +
Osteosarcom<ref name="ref1" />.
 +
 
 +
===Expression===
 +
[[File:LINC00628-1.png|right|thumb|600px|LINC00628 expression was decreased in osteosarcoma tissues and associated with the metastasis and poor prognosis of cancer.<ref name="ref1" />.]]
 +
LINC00628 expression was decreased in osteosarcoma tissues and cell lines and associated with the metastasis and poor prognosis of cancer<ref name="ref1" />.
 +
{| class='wikitable' style="text-align:center"
 +
|-
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! | Experiment
 +
! | Forward primer
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! | Reverse primer
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|-
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| rowspan="1"|Quantitative real-time PCR
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| | 5'-AGAGCGAGCAGGATGAGATAGT- 3'
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| | 5'-GTGAGCAAGGAAGTTGACAGTG- 3'<ref name="ref1" />
 +
|}
 +
 
 +
===Evolution===
 +
-
 
===pubmed IDs===
 
===pubmed IDs===
−
12477932
+
12477932, 30280767
 
===Sequence===
 
===Sequence===
 
>gi|224282134|ref|NR_027022.1| Homo sapiens long intergenic non-protein coding RNA 628 (LINC00628), long non-coding RNA
 
>gi|224282134|ref|NR_027022.1| Homo sapiens long intergenic non-protein coding RNA 628 (LINC00628), long non-coding RNA
 
<dnaseq>AGCCAACTGGTTGTCTAAGGCTGGGAAGGGGTTAAGATGCCCCCGGAGCTTGCCGCGAGGGCAGCTGCCTCAGCGGGCACTCCGCCTGGATGGGAATATAAGCACTCTTGGTGTTGCCCAGGCAGAGAGGGCAGTGTGGAGGGAAGTTGCTAGAAAAAGGCAGGGGACATAATCCATACTGGCCTCTTTCCCAGGCACATCACAGTGGCAGAATTATTTATGATTCTGACCCAATGGGGATCCCTCTACTTGGGGAGACTGCCAACCCACGCCCTCCTGAATGGCAACGTCCTCCCACAGAGACAGAGGGGAACAAGTAGCATTTATGGAGCGGCACAGAGGAAAGAGTGTGGGCTTTGGAGACAGCACAGCAGCACTCACATCCCGGCCCAGACACTTCCTGTGTGACCTTGAGCCAGTTGATGAACCTGTCTGGGCCTCTGTTTCCTCATCTGTTATCGGCGAAAATGTTTCGGAGGACACCTATTGTATAATGTTGCTATGCAGATTAAATGCACTAGCAGAGGCAAAGTGCATAGCTTAGAGGAAGGAAGTACTCGCTAAGTGGTAGCTGGTGTGATAGGTGGGCCAAGTCCTGGCAGGAGCTGGGCTTGCTGGCTGCCCTGTTTTGCTGAAACAGCAGCATCACCATCAGCAGCAACTGTGGAAATATAGACCCTTGATAAATACAGGTGAATAAAATGAATGATTAGAAACTGGACCTGCCACTCTGCAGAACCCAGGCACTGCTCCCCAGCAGCTGGTGCCTCAAAGCAGCTGCTAACATGGCAGGAGACAGTCAGACCAGCAGTGAATAGCTATGCTTCGTAAGACTTCATACACAAGGCAGGCGTGTGGACTGACCAGAAAGGTGGCAGTCACTGTCCATCAAGAGAATCCCCACCTGTTTTCCAATATGTCAGCCAGGAGGCTCGCACTCCCAAAAGGAATGTTCTCAGCCAGCTCCCTGACTGTCCCCACCTCTGACAGTGGACTCTCTTGGGTCTCTCAAAAGGCTCCTCCTCCTCAGCCATGGGGTGAAGGAATCCTGTTTGCCGGGGAGGCGGGATGCTGCCCAGGGTGGCTGTTTTGGGAGAGCGAGCAGGATGAGATAGTGCCTATGAGTGATCTTTGGAGATGGAGGTGCTATGGCCACCTGTGGGGACTGCCTGGGTGCCTCCTGGCCACTGTCAACTTCCTTGCTCACACTGAGATTCTGTGATTCTCCTCTGAGCATTTCCATGGATAATTTTTTTTTTTCAGAGACACTATTAAAGATTTTAAAAATTG</dnaseq>
 
<dnaseq>AGCCAACTGGTTGTCTAAGGCTGGGAAGGGGTTAAGATGCCCCCGGAGCTTGCCGCGAGGGCAGCTGCCTCAGCGGGCACTCCGCCTGGATGGGAATATAAGCACTCTTGGTGTTGCCCAGGCAGAGAGGGCAGTGTGGAGGGAAGTTGCTAGAAAAAGGCAGGGGACATAATCCATACTGGCCTCTTTCCCAGGCACATCACAGTGGCAGAATTATTTATGATTCTGACCCAATGGGGATCCCTCTACTTGGGGAGACTGCCAACCCACGCCCTCCTGAATGGCAACGTCCTCCCACAGAGACAGAGGGGAACAAGTAGCATTTATGGAGCGGCACAGAGGAAAGAGTGTGGGCTTTGGAGACAGCACAGCAGCACTCACATCCCGGCCCAGACACTTCCTGTGTGACCTTGAGCCAGTTGATGAACCTGTCTGGGCCTCTGTTTCCTCATCTGTTATCGGCGAAAATGTTTCGGAGGACACCTATTGTATAATGTTGCTATGCAGATTAAATGCACTAGCAGAGGCAAAGTGCATAGCTTAGAGGAAGGAAGTACTCGCTAAGTGGTAGCTGGTGTGATAGGTGGGCCAAGTCCTGGCAGGAGCTGGGCTTGCTGGCTGCCCTGTTTTGCTGAAACAGCAGCATCACCATCAGCAGCAACTGTGGAAATATAGACCCTTGATAAATACAGGTGAATAAAATGAATGATTAGAAACTGGACCTGCCACTCTGCAGAACCCAGGCACTGCTCCCCAGCAGCTGGTGCCTCAAAGCAGCTGCTAACATGGCAGGAGACAGTCAGACCAGCAGTGAATAGCTATGCTTCGTAAGACTTCATACACAAGGCAGGCGTGTGGACTGACCAGAAAGGTGGCAGTCACTGTCCATCAAGAGAATCCCCACCTGTTTTCCAATATGTCAGCCAGGAGGCTCGCACTCCCAAAAGGAATGTTCTCAGCCAGCTCCCTGACTGTCCCCACCTCTGACAGTGGACTCTCTTGGGTCTCTCAAAAGGCTCCTCCTCCTCAGCCATGGGGTGAAGGAATCCTGTTTGCCGGGGAGGCGGGATGCTGCCCAGGGTGGCTGTTTTGGGAGAGCGAGCAGGATGAGATAGTGCCTATGAGTGATCTTTGGAGATGGAGGTGCTATGGCCACCTGTGGGGACTGCCTGGGTGCCTCCTGGCCACTGTCAACTTCCTTGCTCACACTGAGATTCTGTGATTCTCCTCTGAGCATTTCCATGGATAATTTTTTTTTTTCAGAGACACTATTAAAGATTTTAAAAATTG</dnaseq>
 +
 +
==Labs working on this lncRNA==
 +
* Center for Joint Surgery, Southwest Hospital, Third Military Medical University, Chongqing (Army Medical University), China. jointsurgury@163.com.
 +
==References==
 +
<references>
 +
<ref name="ref1">
 +
He R, Wu JX, Zhang Y, Che H, Yang L. LncRNA LINC00628 overexpression inhibits the growth and invasion through regulating PI3K/Akt signaling pathway in osteosarcoma. Eur Rev Med Pharmacol Sci. 2018 Sep;22(18):5857-5866.
 +
</ref>(1)
 +
</references>

Latest revision as of 08:33, 13 August 2019

Annotated Information

Name

Approved Symbol: LINC00628

Approved Name: long intergenic non-protein coding RNA 628

RefSeq ID: NR_027022

LncBook transcript ID: HSALNT0020406

Ensembl ID: ENSG00000280924

Chromosome

1q32.1

Characteristics

LncRNA LINC00628 locates in the second intron of PLEKHA6 (pleckstrin homology domain-containing A6) in chromosome 1q32.1, the mature RNA of which is 1290bp and has a poly-A tail and is discovered in many tumor formations[1].

Function

  • The overexpression of LINC00628 inhibited the proliferation, invasion and migration and promoted cell apoptosis in osteosarcoma cells through the inactivation of PI3K/Akt signaling pathway[1].

Regulation

-

Diseases

Osteosarcom[1].

Expression

LINC00628 expression was decreased in osteosarcoma tissues and associated with the metastasis and poor prognosis of cancer.[1].

LINC00628 expression was decreased in osteosarcoma tissues and cell lines and associated with the metastasis and poor prognosis of cancer[1].

Experiment Forward primer Reverse primer
Quantitative real-time PCR 5'-AGAGCGAGCAGGATGAGATAGT- 3' 5'-GTGAGCAAGGAAGTTGACAGTG- 3'[1]

Evolution

-

pubmed IDs

12477932, 30280767

Sequence

>gi|224282134|ref|NR_027022.1| Homo sapiens long intergenic non-protein coding RNA 628 (LINC00628), long non-coding RNA

000001 AGCCAACTGG TTGTCTAAGG CTGGGAAGGG GTTAAGATGC CCCCGGAGCT TGCCGCGAGG GCAGCTGCCT CAGCGGGCAC 000080
000081 TCCGCCTGGA TGGGAATATA AGCACTCTTG GTGTTGCCCA GGCAGAGAGG GCAGTGTGGA GGGAAGTTGC TAGAAAAAGG 000160
000161 CAGGGGACAT AATCCATACT GGCCTCTTTC CCAGGCACAT CACAGTGGCA GAATTATTTA TGATTCTGAC CCAATGGGGA 000240
000241 TCCCTCTACT TGGGGAGACT GCCAACCCAC GCCCTCCTGA ATGGCAACGT CCTCCCACAG AGACAGAGGG GAACAAGTAG 000320
000321 CATTTATGGA GCGGCACAGA GGAAAGAGTG TGGGCTTTGG AGACAGCACA GCAGCACTCA CATCCCGGCC CAGACACTTC 000400
000401 CTGTGTGACC TTGAGCCAGT TGATGAACCT GTCTGGGCCT CTGTTTCCTC ATCTGTTATC GGCGAAAATG TTTCGGAGGA 000480
000481 CACCTATTGT ATAATGTTGC TATGCAGATT AAATGCACTA GCAGAGGCAA AGTGCATAGC TTAGAGGAAG GAAGTACTCG 000560
000561 CTAAGTGGTA GCTGGTGTGA TAGGTGGGCC AAGTCCTGGC AGGAGCTGGG CTTGCTGGCT GCCCTGTTTT GCTGAAACAG 000640
000641 CAGCATCACC ATCAGCAGCA ACTGTGGAAA TATAGACCCT TGATAAATAC AGGTGAATAA AATGAATGAT TAGAAACTGG 000720
000721 ACCTGCCACT CTGCAGAACC CAGGCACTGC TCCCCAGCAG CTGGTGCCTC AAAGCAGCTG CTAACATGGC AGGAGACAGT 000800
000801 CAGACCAGCA GTGAATAGCT ATGCTTCGTA AGACTTCATA CACAAGGCAG GCGTGTGGAC TGACCAGAAA GGTGGCAGTC 000880
000881 ACTGTCCATC AAGAGAATCC CCACCTGTTT TCCAATATGT CAGCCAGGAG GCTCGCACTC CCAAAAGGAA TGTTCTCAGC 000960
000961 CAGCTCCCTG ACTGTCCCCA CCTCTGACAG TGGACTCTCT TGGGTCTCTC AAAAGGCTCC TCCTCCTCAG CCATGGGGTG 001040
001041 AAGGAATCCT GTTTGCCGGG GAGGCGGGAT GCTGCCCAGG GTGGCTGTTT TGGGAGAGCG AGCAGGATGA GATAGTGCCT 001120
001121 ATGAGTGATC TTTGGAGATG GAGGTGCTAT GGCCACCTGT GGGGACTGCC TGGGTGCCTC CTGGCCACTG TCAACTTCCT 001200
001201 TGCTCACACT GAGATTCTGT GATTCTCCTC TGAGCATTTC CATGGATAAT TTTTTTTTTT CAGAGACACT ATTAAAGATT 001280
001281 TTAAAAATTG

Labs working on this lncRNA

  • Center for Joint Surgery, Southwest Hospital, Third Military Medical University, Chongqing (Army Medical University), China. jointsurgury@163.com.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 He R, Wu JX, Zhang Y, Che H, Yang L. LncRNA LINC00628 overexpression inhibits the growth and invasion through regulating PI3K/Akt signaling pathway in osteosarcoma. Eur Rev Med Pharmacol Sci. 2018 Sep;22(18):5857-5866.
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