Difference between revisions of "EGFLAM-AS1"
(Created page with "==Annotation== ===Name=== EGFLAM-AS1 ===Alias=== lncRNA-LOWEG ===Disease=== Disease: gastric cancer [http://www.ncbi.nlm.nih.gov/pubmed/26537802 (PMID:26537802)] Dysfunctio...") |
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==Annotation== | ==Annotation== | ||
===Name=== | ===Name=== | ||
| − | EGFLAM-AS1 | + | Approved symbol: EGFLAM-AS1 |
| − | + | Alias: lncRNA-LOWEG, CTD-2108O9.1 | |
| − | lncRNA-LOWEG | ||
| − | + | HGNC ID：HGNC:41169 | |
| − | |||
| − | + | Ensembl ID: ENSG00000249491 | |
| − | + | LncBook transcript ID: HSALNT0086786 | |
| + | ===Characteristics=== | ||
| + | - | ||
| + | ===Function=== | ||
| + | [[File:EGFLAM-AS1-fun.png|right|thumb|400px|Downregulation of long non-coding RNA (lncRNA)-CTD-2108O9.1 in breast cancer and its inhibitory effects on | ||
| + | metastasis through its associated metastatic inhibitor leukemia inhibitory factor receptor (LIFR), epithelial-mesenchymal transition (EMT)-related genes and MMP family<ref name="ref2" />.]] | ||
| + | *lncRNA-CTD-2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor(LIFR), which is designated as a metastasis suppressor in BC<ref name="ref2" />. | ||
| + | |||
| + | ===Regulation=== | ||
| + | - | ||
| + | ===Diseases=== | ||
| + | Gastric cancer<ref name="ref1" /> | ||
| + | |||
| + | Breast cancer<ref name="ref2" /> | ||
| + | |||
| + | ===Expression=== | ||
| + | Significantly reduced expression of lncRNA-LOWEG was found in gastric cancer tissues and cell lines (SGC-7901, AGS, BGC-823 and HG-27) compared with patient-matched nontumorous adjacent tissues (P < 0.01) or the normal gastric cell line GES-1 (P < 0.05). Lastly, western blot and real-time PCR analysis suggested that lncRNA-LOWEG is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level<ref name="ref1" />. | ||
| − | === | + | RNA-CTD-2108O9.1 is downregulated in Breast cancer (BC) tissues and cells and acts as a metastatic inhibitor of BC<ref name="ref2" />. |
| − | + | ===Evolution=== | |
| + | - | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | *Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China. | ||
| − | + | *Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China | |
| − | + | ==References== | |
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Zhao J, Sun J, Song Y, et al. A novel long noncoding RNA-LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion[J]. Journal of cancer research and clinical oncology, 2016, 142(3): 601-609. | ||
| + | </ref>(1) | ||
| + | <ref name="ref2"> | ||
| + | Wang M, Wang M, Wang Z, et al. Long non‐coding RNA‐CTD‐2108O9. 1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor[J]. Cancer science, 2018, 109(6): 1764-1774. | ||
| + | </ref>(2) | ||
| + | </references> | ||
Latest revision as of 07:08, 14 August 2019
Contents
Annotation
Name
Approved symbol: EGFLAM-AS1
Alias: lncRNA-LOWEG, CTD-2108O9.1
HGNC ID：HGNC:41169
Ensembl ID: ENSG00000249491
LncBook transcript ID: HSALNT0086786
Characteristics
-
Function
Downregulation of long non-coding RNA (lncRNA)-CTD-2108O9.1 in breast cancer and its inhibitory effects on metastasis through its associated metastatic inhibitor leukemia inhibitory factor receptor (LIFR), epithelial-mesenchymal transition (EMT)-related genes and MMP family[1].
- lncRNA-CTD-2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor(LIFR), which is designated as a metastasis suppressor in BC[1].
Regulation
-
Diseases
Gastric cancer[2]
Breast cancer[1]
Expression
Significantly reduced expression of lncRNA-LOWEG was found in gastric cancer tissues and cell lines (SGC-7901, AGS, BGC-823 and HG-27) compared with patient-matched nontumorous adjacent tissues (P < 0.01) or the normal gastric cell line GES-1 (P < 0.05). Lastly, western blot and real-time PCR analysis suggested that lncRNA-LOWEG is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level[2].
RNA-CTD-2108O9.1 is downregulated in Breast cancer (BC) tissues and cells and acts as a metastatic inhibitor of BC[1].
Evolution
-
Labs working on this lncRNA
- Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
- Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China
References
- ↑ 1.0 1.1 1.2 1.3 Wang M, Wang M, Wang Z, et al. Long non‐coding RNA‐CTD‐2108O9. 1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor[J]. Cancer science, 2018, 109(6): 1764-1774.
- ↑ 2.0 2.1 Zhao J, Sun J, Song Y, et al. A novel long noncoding RNA-LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion[J]. Journal of cancer research and clinical oncology, 2016, 142(3): 601-609.
