Difference between revisions of "LINC01703"
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Alias symbol：lncPARP1 | Alias symbol：lncPARP1 | ||
| − | RefSeq | + | RefSeq ID：NR_146920 |
===Characteristics=== | ===Characteristics=== | ||
Latest revision as of 01:06, 15 January 2021
LINC01703, regulates the expression of PARP1 and is a novel molecule involved in the progression of HCC
Contents
Annotated Information
Approved Symbol
Approved symbol：LINC01703
Approved name：long intergenic non-protein coding RNA 1703
HGNC ID：HGNC:52491
Alias symbol：lncPARP1
RefSeq ID：NR_146920
Characteristics
lsoLINC01703 is a long noncoding RNA with GeneSymbol: BC032899 also named as lncPARP1 [1]. LINC01703 is located downstream of PARP1 gene [1].
Function
LINC01703 regulate the DNA repair in response to DNA damage through PARP1-p53 signaling. PARP1 also plays important role in mesenchymal–epithelial transition (EMT) which promotes tumor metastasis [1]. LINC01703 promotes proliferation and inhibits apoptosis in HCC cells [1]. Knockdown of LINC01703 represses migration and invasion in HCC cells [1]. LINC01703 positively modulate PARP1 expression [1]. Deletion of v suppresses HCC growth in vivo [1].
Regulation
NA
Diseases
- Hepatocellular Carcinoma [1].
Expression
LINC01703 is significantly up-regulated in HCC tissues [1].
Labs working on this lncRNA
- Department of Hepatobiliary Surgery, Zhongshan Hospital, Xiamen University, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Xiamen, Fujian, P.R. China
- Department of Oncology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, P.R. China
- Faculty of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, P.R. China
- Department of Biomaterials, College of Materials, Xiamen University, Xiamen, Fujian, P.R. China
References
Sequence
>gi|105373113|ref|NR_146920.1|Homo sapiens long intergenic non-protein coding RNA 1703 (LINC01703), long non-coding RNA
000081 ACGGGCCCTT CTCCGCCAGC CCTGGCTGGG TCACCCCCAC GACCCGGGAC TCCCCCGCCG TTCCCTCCCG GGCTGCCTGC 000160
000161 AGTGAGGTCC GCTCCTGAGG CCTCAGCCTC GCCGGGGGTA GGGCCCTCTC CCGCCGTCGC CGCAGCTCCT TTCCGTCCCG 000240
000241 GGGCCTGGGG GGCACCGTCC CACGGGTGAG GGCCGCCTCC AGCGCCTGGC CCAGCCATGC GAACGCCTGG AGCCCGCGAG 000320
000321 CTGCAGCTGC GGCCCTGAAG GTGCCGCATA TCCTGCCGAG TGGGTGAAGC GTGGCACTTT GGAAAACAAA TCGGGTGATC 000400
000401 CGCCCACCTC GGCCTCCCAA AGTGCTGGAA TTACAGGCAT GAACCACGGT GCCCGGCTGA CACAAGGAAC TTTCTATGAG 000480
000481 GTCCTAGGAA TGAAGGAAAA CAGGCAATAA GGCAAGAATC GCTGTCGAAG GAGTCTGCGC CACCTGCTCG CACAGCTCAC 000560
000561 TTGTGCCTTC TGAGCCTGCT GGAGCCCAGT GTACATATGC CGTCTCCGCG TGATTAGAGA TTGCTGCTGC ACGTGCCCAA 000640
000641 TCCCGTGGCG GGGCTGGAAC ACAAACGGGG TGGTGTTCCA GCTGCAACCA TGCAGATGAA GACTATACCC TAGGAGATGG 000720
000721 AGGAACAACA GACAAGAAAG AAACCTGGGT TCCTGAATAA CCACGTGGAG CCAAGCAGCT TACTTATCTC AAGCCACTGT 000800
000801 TGCCCACCTC CAGATTGAAC TGTCTGCAAA CAAATCTTTA CTTGATGAGA AGTTTAAATA TAATTAAATC TAGAATATTA 000880
000881 CA
