Difference between revisions of "RN7SL1"
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===Characteristics=== | ===Characteristics=== | ||
| − | The | + | The RN7SL1 locus is an authentic 7SL RNA gene encoding one of the three sequence variants of human 7SL RNA.<ref name="ref1" /> |
| − | Comparison of the upstream regions revealed the presence of two conserved elements in the two human | + | Comparison of the upstream regions revealed the presence of two conserved elements in the two human RN7SL1 genes, an ATF/CRE binding site at -43 to -50 and a TATA-like box centered around position -25.<ref name="ref2" /> |
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===Function=== | ===Function=== | ||
Two sequence motifs can be identified in RN7SL1 at positions 10-19 and 50-60, respectively, downstream of the transcription start site that resemble putative A and B boxes. Single and multiple nucleotide substitutions in these regions also influenced transcription activity to a great extent.<ref name="ref2" /> | Two sequence motifs can be identified in RN7SL1 at positions 10-19 and 50-60, respectively, downstream of the transcription start site that resemble putative A and B boxes. Single and multiple nucleotide substitutions in these regions also influenced transcription activity to a great extent.<ref name="ref2" /> | ||
Latest revision as of 08:43, 19 February 2021
RN7SL1,transcribed by RNA polymerase III, influences transcription activity.[1][2]
Contents
Annotated Information
Name
Approved symbol:RN7SL1
Approved name:RNA component of signal recognition particle 7SL1
HGNC ID:10038
Previous name:RNA, 7SL, cytoplasmic|RNA, 7SL, cytoplasmic 1
Alias symbol:7SL|7L1a|RNSRP1
RefSeq ID:NR_002715
LncBook ID:HSALNG014164
Prev_symbol:RN7SL
Characteristics
The RN7SL1 locus is an authentic 7SL RNA gene encoding one of the three sequence variants of human 7SL RNA.[1] Comparison of the upstream regions revealed the presence of two conserved elements in the two human RN7SL1 genes, an ATF/CRE binding site at -43 to -50 and a TATA-like box centered around position -25.[2]
Function
Two sequence motifs can be identified in RN7SL1 at positions 10-19 and 50-60, respectively, downstream of the transcription start site that resemble putative A and B boxes. Single and multiple nucleotide substitutions in these regions also influenced transcription activity to a great extent.[2]
Expression
RN7SL1 is expressed in HeLa cells.[1]
Diseases
Human skin diseases[1]
Labs working on this lncRNA
- Department of Molecular Biophysics and Biochemistry, Yale University,P.O. Box 3333, New Haven, CT 06510, USA.[1]
- Institut für Biochemie, Universität Würzburg, Biozentrum, Am Hubland, D-97074 Würzburg, Germany.[2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Ullu E, Weiner AM. Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. EMBO J. 1984 Dec 20;3(13):3303-10.
- ↑ 2.0 2.1 2.2 2.3 Englert M, Felis M, Junker V, Beier H. Novel upstream and intragenic control elements for the RNA polymerase III-dependent transcription of human 7SL RNA genes. Biochimie. 2004 Dec;86(12):867-74. doi: 10.1016/j.biochi.2004.10.012.
