Difference between revisions of "CALHM6-AS1"
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Approved name:CALHM6 antisense RNA 1 | Approved name:CALHM6 antisense RNA 1 | ||
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Alias symbol:RP1-93H18.6 | Alias symbol:RP1-93H18.6 |
Latest revision as of 10:24, 19 February 2021
Suppression of CALHM6-AS1 exerts potent inhibitory effects on the development and progression of CC via blockade of the PI3K/Akt axis.
Contents
Annotated Information
Name
Approved symbol:CALHM6-AS1
Approved name:CALHM6 antisense RNA 1
HGNC ID:40971
Alias symbol:RP1-93H18.6
Function
CALHM6-AS1 vectors exposure increased cell viability, adhesion, migration, and invasion, which resulted in more cells arrested at the S stage and reduced apoptosis, while acting to promote tumor growth and metastasis. [1].
Expression
CALHM6-AS1 was highly expressed in CC, which could activate the P13K/Akt axis[1].
Regulation
The siRNA against CALHM6-AS1 exposure was observed to attenuate the effects induced by RP1-93H18.6 vectors. [1].
Diseases
- Cervical cancer [1].
Labs working on this lncRNA
- Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China[1].
- Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China[1].
- Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, P.R. China[1].
- Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China. Electronic address: grxcdxzzu@163.com.Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China[1].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Wang Q, Yan SP, Chu DX, Xie Y, Wang CF, Zhang JY, Li WC, Guo RX. Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt Axis. Mol Ther Nucleic Acids. 2020 Mar 6;19:304-317. doi: 10.1016/j.omtn.2019.10.041.