Difference between revisions of "CALHM6-AS1"

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Approved name:CALHM6 antisense RNA 1
 
Approved name:CALHM6 antisense RNA 1
  
HGNC ID:HGNC:40971
+
HGNC ID:40971
  
 
Alias symbol:RP1-93H18.6
 
Alias symbol:RP1-93H18.6

Latest revision as of 10:24, 19 February 2021

Suppression of CALHM6-AS1 exerts potent inhibitory effects on the development and progression of CC via blockade of the PI3K/Akt axis.

Annotated Information

Name

Approved symbol:CALHM6-AS1

Approved name:CALHM6 antisense RNA 1

HGNC ID:40971

Alias symbol:RP1-93H18.6

Function

CALHM6-AS1 vectors exposure increased cell viability, adhesion, migration, and invasion, which resulted in more cells arrested at the S stage and reduced apoptosis, while acting to promote tumor growth and metastasis. [1].

Expression

CALHM6-AS1 was highly expressed in CC, which could activate the P13K/Akt axis[1].

Regulation

The siRNA against CALHM6-AS1 exposure was observed to attenuate the effects induced by RP1-93H18.6 vectors. [1].

Diseases

  • Cervical cancer [1].

Labs working on this lncRNA

  • Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China[1].
  • Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China[1].
  • Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, P.R. China[1].
  • Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China. Electronic address: grxcdxzzu@163.com.Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China[1].

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Wang Q, Yan SP, Chu DX, Xie Y, Wang CF, Zhang JY, Li WC, Guo RX. Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt Axis. Mol Ther Nucleic Acids. 2020 Mar 6;19:304-317. doi: 10.1016/j.omtn.2019.10.041.