Difference between revisions of "DLEU2L"

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BCMSUNL (for BCMSUN-like) is a homolog of BCMSUN which is isolated from the minimally deleted region.
 
==Annotated Information==
 
==Annotated Information==
 
===Name===
 
===Name===
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Approved name: deleted in lymphocytic leukemia 2 like
 
Approved name: deleted in lymphocytic leukemia 2 like
  
HGNC ID: HGNC:13225
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HGNC ID: 13225
  
 
Previous names: BCMS upstream neighbor-like
 
Previous names: BCMS upstream neighbor-like
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===Function===
 
===Function===
[[File:LeXis functions as a ceRNA of β-catenin.jpg|right|thumb|LeXis functions as a ceRNA of β-catenin([https://www.ncbi.nlm.nih.gov/pubmed/28744406 (Wang G 2017)])]]
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Please input evolution information here.
LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism([https://www.ncbi.nlm.nih.gov/pubmed/27251289 (Sallam T 2016)]).
 
 
 
LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth([https://www.ncbi.nlm.nih.gov/pubmed/28744406 (Wang G 2017)]).
 
  
 
===Disease===
 
===Disease===
* osteosarcoma
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Please input evolution information here.
* colon adenocarcinoma <ref name="ref1" />
 
  
 
===Evolution===
 
===Evolution===
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==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
* No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
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* Abteilung "Organisation komplexer Genome", Deutsches Krebsforschungszentrum, Heidelberg, Germany.
* Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.
 
  
 
==References==
 
==References==
 
<references>
 
<references>
<ref name="ref1"> Shahriyari L. Effect of normalization methods on the performance of supervised
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<ref name="ref1">Mertens D, Wolf S, Bullinger L, Ohl S, Schaffner C, Döhner H, Stilgenbauer S, Lichter P. BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like. Int J Cancer. 2000 Dec 1;88(5):692-7. doi: 10.1002/1097-0215(20001201)88:5<692::aid-ijc2>3.0.co;2-3. </ref>
learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a
 
predictor of survival in patients with colon adenocarcinoma. Brief Bioinform.
 
2017 Nov 3. doi: 10.1093/bib/bbx153.
 
</ref>(1)
 
 
</references>
 
</references>
[http://www.lncrnadb.org/7SK/ Annotation originally sourced from lncRNAdb].
 
 
 
[[Category:Intergenic]][[Category:NONHSAG043942]][[Category:Transcripts]]
 

Latest revision as of 10:38, 19 February 2021

BCMSUNL (for BCMSUN-like) is a homolog of BCMSUN which is isolated from the minimally deleted region.

Annotated Information

Name

Approved symbol: DLEU2L

Approved name: deleted in lymphocytic leukemia 2 like

HGNC ID: 13225

Previous names: BCMS upstream neighbor-like

Alias symbols: BCMSUNL

RefSeq ID: NR_002771

Characteristics

Chromosomal localization of the BCMSUNL gene((Mertens D 2000))

BCMSUNL located at 1p22-p31, not part of the critical deletion region of 1p22 in MCLs. BCMSUNL has intronless, lacks exon 2 and shows 90.3% homology on the nucleic acid levelcompare with BCMSUN.

Expression

Expressed in peripheral blood lymphocytes from healthy donors as well as B‐CLL and MCL tumors((Mertens D 2000)) .

Regulation

Please input evolution information here.

Function

Please input evolution information here.

Disease

Please input evolution information here.

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • Abteilung "Organisation komplexer Genome", Deutsches Krebsforschungszentrum, Heidelberg, Germany.

References

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