Difference between revisions of "FAM99A"

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(Created page with "The alterations in the lncRNA family with sequence similarity 99 member A (FAM99A) in PE and its effects on trophoblasts. ==Annotated Information== ===Name=== Approved symbol...")
 
 
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===Function===
 
===Function===
FAM99A may serve a role in modulating the functions of trophoblasts, partially via targeting Wnt/β catenin signaling. <ref name="ref" />.
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FAM99A may serve a role in modulating the functions of trophoblasts, partially via targeting Wnt/β catenin signaling. <ref name="ref1" />.
  
EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression<ref name="ref" />.  
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EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression<ref name="ref1" />.  
 
===Regulation===
 
===Regulation===
 
Overexpression of FAM99A promoted invasion and migration of HTR 8/SVneo cells; conversely, knockdown of FAM99A suppressed the invasive and migratory abilities of HTR 8/SVneo cells.<ref name="ref1" />.
 
Overexpression of FAM99A promoted invasion and migration of HTR 8/SVneo cells; conversely, knockdown of FAM99A suppressed the invasive and migratory abilities of HTR 8/SVneo cells.<ref name="ref1" />.
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==References==
 
==References==
 
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<ref name="ref1">He T, Qiao Y, Lv Y, Wang J, Hu R, Cao Y. lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. Mol Med Rep. 2019 Aug;20(2):1451-1458. doi: 10.3892/mmr.2019.10350. Epub 2019 Jun 5. </ref>
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<ref name="ref1">He T, Qiao Y, Lv Y, Wang J, Hu R, Cao Y. lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. Mol Med Rep. 2019 Aug;20(2):1451-1458. doi: 10.3892/mmr.2019.10350. Epub 2019 Jun 5. </ref>(1)
 
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Latest revision as of 10:53, 19 February 2021

The alterations in the lncRNA family with sequence similarity 99 member A (FAM99A) in PE and its effects on trophoblasts.

Annotated Information

Name

Approved symbol:FAM99A

Approved name:family with sequence similarity 99 member A

HGNC ID:HGNC:32368

Previous name:family with sequence similarity 99, member A|family with sequence similarity 99, member A (non-protein coding)|family with sequence similarity 99 member A (non-protein coding)

Alias symbol:FLJ42833

RefSeq ID:NR_026643

LncBook ID:[1]

Characteristics

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Function

FAM99A may serve a role in modulating the functions of trophoblasts, partially via targeting Wnt/β catenin signaling. [1].

EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression[1].

Regulation

Overexpression of FAM99A promoted invasion and migration of HTR 8/SVneo cells; conversely, knockdown of FAM99A suppressed the invasive and migratory abilities of HTR 8/SVneo cells.[1].

Expression

FAM99A overexpression induced a decrease in the apoptotic rate of cells, whereas knockdown of FAM99A increased the apoptotic rate of HTR 8/SVneo cells. [1].

Diseases

  • Preeclampsia (PE)[1].

Labs working on this lncRNA

  • Obstetrics and Gynecology Intensive Care Unit, The Northwest Women and Children's Hospital, Xi'an, Shaanxi 718900, P.R. China.[1]
  • Department of Obstetrics, The Northwest Women and Children's Hospital, Xi'an, Shaanxi 718900, P.R. China.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 He T, Qiao Y, Lv Y, Wang J, Hu R, Cao Y. lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. Mol Med Rep. 2019 Aug;20(2):1451-1458. doi: 10.3892/mmr.2019.10350. Epub 2019 Jun 5.