Difference between revisions of "LINC02882"
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LINC02882 and miR-490-3p form a regulatory loop.<ref name="ref1" /> | LINC02882 and miR-490-3p form a regulatory loop.<ref name="ref1" /> | ||
===Function=== | ===Function=== | ||
| − | [[File:LINC02882-fun.png|thumb|550px| | + | [[File:LINC02882-fun.png|thumb|550px|LINC02882 knockdown inhibits hepatic carcinoma cell proliferation, migration, and invasion. <ref name="ref1"/>]] |
| − | LINC02882 binds to and regulates miR-490-3p expression in the HCC cells which can control the HCC related pathogenesis.<ref name="ref1" /> | + | LINC02882 binds to and regulates miR-490-3p expression in the HCC cells which can control the HCC related pathogenesis.<ref name="ref1" /> |
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===Regulation=== | ===Regulation=== | ||
LINC02882 regulates the expression of TNKS2 via miR-490-3p.<ref name="ref1" /> | LINC02882 regulates the expression of TNKS2 via miR-490-3p.<ref name="ref1" /> | ||
Latest revision as of 01:58, 21 February 2021
A long non-coding RNA,LINC02882, which is enriched in HCC and can promote its proliferation, migration, and invasion both in vitro and in vivo. [1]
Contents
Annotated Information
Name
Approved symbol：LINC02882
HGNC ID：54802
Approved name：long intergenic non-protein coding RNA 2882
Alias symbol：RP11-81H3.2
RefSeq ID：NR_038300
Characteristics
location:12q21.1 LINC02882 and miR-490-3p form a regulatory loop.[1]
Function
LINC02882 knockdown inhibits hepatic carcinoma cell proliferation, migration, and invasion. [1]
LINC02882 binds to and regulates miR-490-3p expression in the HCC cells which can control the HCC related pathogenesis.[1]
Regulation
LINC02882 regulates the expression of TNKS2 via miR-490-3p.[1]
Expression
Expression of LINC02882 is upregulated in hepatic carcinoma tissues and cell lines.[1]
The release of LINC02882 leads to the suppression of miR-490-3p expression, thus, further enhancing the expression of LINC02882.
Diseases
Hepatocellular carcinoma (HCC)[1]
Labs working on this lncRNA
- Department of Surgical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Chen W, Li K, Zhu K, Yan R, Cai QC, Li WH, Dang CX. RP11-81H3.2 Acts as an Oncogene via microRNA-490-3p Inhibition and Consequential Tankyrase 2 Up-Regulation in Hepatocellular Carcinoma. Dig Dis Sci. 2020 Oct;65(10):2949-2958. doi: 10.1007/s10620-019-06007-5. Epub 2019 Dec 19. PMID: 31858324.
