Difference between revisions of "ROCR"
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ROCR is required for successful differentiation of mesenchymal stem cells (MSCs) into chondrocytes where it appears to contribute to SOX9 expression.<ref name="ref1" /> | ROCR is required for successful differentiation of mesenchymal stem cells (MSCs) into chondrocytes where it appears to contribute to SOX9 expression.<ref name="ref1" /> | ||
===Regulation=== | ===Regulation=== | ||
| − | [[File: ROCR. | + | [[File: ROCR-reg.jpeg|thumb|550px| Effect of ROCR depletion on MSC chondrogenic differentiation. <ref name="ref1"/>]] |
ROCR depletion reduced DNA levels, it was required for MSC proliferation during the early stages of chondrocyte differentiation.<ref name="ref1" /> | ROCR depletion reduced DNA levels, it was required for MSC proliferation during the early stages of chondrocyte differentiation.<ref name="ref1" /> | ||
Latest revision as of 04:02, 22 February 2021
ROCR indicating an important role in chondrocyte biology.[1]
Contents
Annotated Information
Name
Approved symbol:ROCR
Approved name:regulator of chondrogenesis RNA
HGNC ID HGNC:52946
Previous name:long intergenic non-protein coding RNA 2095
RefSeq ID:NR_110876
LncBook ID:HSALNG0129765|HSALNG0118528
Prev_symbol:LINC02095
Characteristics
ROCR were enriched in the cytoplasm.[1]
Function
ROCR is required for successful differentiation of mesenchymal stem cells (MSCs) into chondrocytes where it appears to contribute to SOX9 expression.[1]
Regulation
Effect of ROCR depletion on MSC chondrogenic differentiation. [1]
ROCR depletion reduced DNA levels, it was required for MSC proliferation during the early stages of chondrocyte differentiation.[1]
Expression
ROCR is upregulated during chondrogenic differentiation of mesenchymal stem cells (MSCs).[1]
Diseases
Neck of femur fracture [1]
Labs working on this lncRNA
- Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK m.j.barter@ncl.ac.uk d.a.young@ncl.ac.uk.[1]
- Musculoskeletal Pathology Group, Institute IDIS, Travesia choupana s/n, Hospital Clínico Universitario de Santiago, Santiago de Compostela, 15706, Spain.[1]
- Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.[1]
- Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.[1]
- Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.[1]
References
[1](1)
</references>- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Barter MJ, Gomez R, Hyatt S, Cheung K, Skelton AJ, Xu Y, Clark IM, Young DA. The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Development. 2017 Dec 15;144(24):4510-4521. doi: 10.1242/dev.152504. Epub 2017 Oct 30.
