Difference between revisions of "NONHSAT035954"
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
''DHRS4-AS1'':DHRS4 antisense RNA 1 (HGNC nomenclature) | ''DHRS4-AS1'':DHRS4 antisense RNA 1 (HGNC nomenclature) | ||
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===Function=== | ===Function=== | ||
| − | AS1DHRS4 Regulates DHRS4 Gene Cluster Transcription | + | AS1DHRS4 Regulates DHRS4 Gene Cluster Transcription by interacting with H3K9 and H3K27 Methyltransferases.<ref name="ref1" /> |
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AS1DHRS4 has both specific cis and trans activity on inducing different repressive enzyme complexes in the individual promoters within the DHRS4 gene cluster locus.<ref name="ref1" /> | AS1DHRS4 has both specific cis and trans activity on inducing different repressive enzyme complexes in the individual promoters within the DHRS4 gene cluster locus.<ref name="ref1" /> | ||
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===Expression=== | ===Expression=== | ||
| − | [[File:AS1DHRS4 is a cis-antisense transcript to the DHRS4 gene.jpg|right|thumb|400px|'''AS1DHRS4 is a cis-antisense transcript to the DHRS4 gene. '''<ref name="ref1" /> | + | [[File:AS1DHRS4 is a cis-antisense transcript to the DHRS4 gene.jpg|right|thumb|400px|'''AS1DHRS4 is a cis-antisense transcript to the DHRS4 gene. '''<ref name="ref1" />]] |
Knockdown of AS1DHRS4 had no effect on DHRS2gene expression at the transcriptional level | Knockdown of AS1DHRS4 had no effect on DHRS2gene expression at the transcriptional level | ||
Knockdown of AS1DHRS4 increased both mature mRNAs and pre-mRNAs of the DHRS4 gene cluster<ref name="ref1" /> | Knockdown of AS1DHRS4 increased both mature mRNAs and pre-mRNAs of the DHRS4 gene cluster<ref name="ref1" /> | ||
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| | antisense:GAGUCUUCAUCCAGAAACATT<ref name="ref1" /> | | | antisense:GAGUCUUCAUCCAGAAACATT<ref name="ref1" /> | ||
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==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Latest revision as of 06:19, 25 June 2016
AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4gene cluster in cis and trans.
Contents
Annotated Information
Name
DHRS4-AS1:DHRS4 antisense RNA 1 (HGNC nomenclature)
Function
AS1DHRS4 Regulates DHRS4 Gene Cluster Transcription by interacting with H3K9 and H3K27 Methyltransferases.[1]
AS1DHRS4 has both specific cis and trans activity on inducing different repressive enzyme complexes in the individual promoters within the DHRS4 gene cluster locus.[1]
Expression
AS1DHRS4 is a cis-antisense transcript to the DHRS4 gene. [1]
Knockdown of AS1DHRS4 had no effect on DHRS2gene expression at the transcriptional level Knockdown of AS1DHRS4 increased both mature mRNAs and pre-mRNAs of the DHRS4 gene cluster[1]
| siRNA Name | Sequences |
|---|---|
| siASDhrs4-1 | sense:AACUCAUUUGGUAAAAUGGTT[1] |
| antisense:CCAUUUUACCAAAUGAGUUTT[1] | |
| siASDhrs4-2 | sense:UGUUUCUGGAUGAAGACUCTTT[1] |
| antisense:GAGUCUUCAUCCAGAAACATT[1] |
Labs working on this lncRNA
Department of Cell Biology, Shantou University Medical College, Shantou 515041, China
References
Basic Information
| Transcript ID |
NONHSAT035954 |
| Source |
NONCODE4.0 |
| Same with |
DHRS4-AS1,C14orf167, "chromosome 14 open reading frame 167", "DHRS4 antisense RNA 1 (non-protein coding)" |
| Classification |
antisense |
| Length |
3038 nt |
| Genomic location |
chr14-:24407940..24423392 |
| Exon number |
2 |
| Exons |
24407940..24410367,24422783..24423392 |
| Genome context |
|
| Sequence |
000001 AGAACACTGG GGAGACTAGA TCGATAGGGC TGCACAGAGG TGGCACAGTT GTGCCAGAGG TAGCAGGGAC AGGAGGGCTG 000080 000081 GCAAGGGAGG GTCCAGGGCT AGGGGATTCG GAGTGGCTTC AGGCGGACCA CGTGGCTACC TTTTTTCCAG GGCCAGACTT 000160 000161 TGGCAGCGTG TAAGGTCTGA GGACAGGGGC ACCGGAGGCC GAGGATGAGA GGCCAGTGCC TGTTTCCAGG CAGCCAGGGC 000240 000241 CTCAGAAACT CCGGCCGGAG CACTCACCCG TCGGTGGAGG CCGTTACCAG GGCCACCTTA TTTGCGAGCG GGTCCCGGCG 000320 000321 GGTCATCCCG GAGCTGGCCA TCCGCACCGA ATTCCAAGCC CGGGCACAGA GGCCTAGCAG CCCCGCCTTG TGCATGGATC 000400 000401 AGACCAGCAA GTATGGGTTC CACTCTTCCC AGGGGCGGTG ACAGAGTAGG GCGAGGGGCA GGACGAAGGG CGGGCCGATT 000480 000481 CCCTGCCCGC CCTGCTCCCC GCCCCGGTAC CGCTGTGAGC GGTCTGTGGC CCTGGGCACC TCCATCCGCC GCGGCGCCCC 000560 000561 TCCACCATCT ACCTTCCGCC TGACTGGGGC TTGCCTTTCC GGGCTGGCGG GTGCCACTTC GGATAAACCC TTTGGACTCC 000640 000641 TAACTCCAAT CAGGTGTCTG CTTTGTTGAG GACTCACAGA CACAGTCTCC TTTCTTCAAG ATCTTTACAA TGCAAGACCT 000720 000721 CACTAACACA CAGGGATGGT CTCCCAGAGG GTCTGTGCTG TTCCTTCACT CAGAACATCA AGATGCACTG AAGTAAGGAT 000800 000801 CCTCTATTCT ACAGTTCCTG CTAGCTGAGC TATTCCATGG GGGCTTCAGC AGGAAATTCC AAGGTTGGCT TTGACAAGCT 000880 000881 AAGGCCGGCT GGTGGAGCAC ATCGAGTTCT GGAGGTTCAT GTGTGTTTTC ATGAAGATCT GTCTGCCCGT AGCAGATAAA 000960 000961 GAGTTGTTGC CCCACTCCTC CTGGGGTCTT CTATTTTCCT GGGAGGAATT TCTGGATTAA CTGAACACAC ACACACACAC 001040 001041 ACACACCCTT TTGAAGCATC AACAGTAATT CTGAGTTCTT AGGGACAATG CAGATTAAAT CCACAATAAG AAAGACAACT 001120 001121 ATGGCCAGGT GTGGTGGCTC ACGCCTGTAA TCCCAGAACT TTGGGAGGCT GAGGCGGATG GATCACCTGA GGTCAGGAGT 001200 001201 TAGAGACCAA CCTGACCAAC ATGGAGAAAC CCCGTTTCTA CTAAAAATGC AAAATTAGCC GGGCATGGTG GCAGGCGCCT 001280 001281 GTAATCCCAA ATACTCGGGA GGCTGAGGCA GGAGAATCAC TTAAACCCGG GAGGCAGAGG TTGCAGTGAG CCAAGATCGC 001360 001361 GCCATTGCAC TCCAGCCTGG GCAAGAAGAG CAAAACTCCA TCTCAAAAAA AAAAAAAGAG TACTATTGAT CCAGAGGTGA 001440 001441 CCAGACTAGC CTCACTGGAG ATAATAGGTG ACATTATTAT GCAAAGTGGT TTCAGTTCCC TTGTCTTGTT TTTGGAATAG 001520 001521 TATAAGAGGC CTACAATACG AATAAATAAG GCCCATCACA AGCCTCACCA AAGGACAAAA CTAATCCACT TCTGAAGAAG 001600 001601 GCTCTTTGTT GGGCCAGATC AAATCCTTGG ACAGAACTGT ACTCTTAATC TCTGTAGTGA AAGTGGGGGG TAGTTTAAGA 001680 001681 ATTTATTAAC CTTCTACCTT GAGCAATCCC TCAGAAGTAA GAGGTGTCAG GCCTCTGAGC CGAAGCTCAG CCATTGTAAC 001760 001761 CCCTGTGACC TGCACATATA TGTCCAGATG GCCTGCAGGA GCCAAGAAGT CTGGGGCAGC TGAAAAACCA CACAAGAAGT 001840 001841 AAAACAGCCA GTTCCTGCCT TAACTGATTA ACCAACATTA CAAC |