Difference between revisions of "NRAV"
(Created page with "==Annotated Information== ===Approved Symbol=== NRAV ===Approved Name=== negative regulator of antiviral response (non-protein coding) ===Previous Symbols=== DYNLL1-AS1 ===Syn...") |
|||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Annotated Information== | ==Annotated Information== | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | NRAV | + | NRAV (negative regulator of antiviral response (non-protein coding)) |
| − | |||
| − | negative regulator of antiviral response (non-protein coding) | ||
===Previous Symbols=== | ===Previous Symbols=== | ||
DYNLL1-AS1 | DYNLL1-AS1 | ||
| − | === | + | [[File:NRAV Negatively Regulates the Expression of Several Critical ISGs.jpg|right|thumb|400px|'''NRAV Negatively Regulates the Expression of Several Critical ISGs'''<ref name="ref1" />]] |
| − | + | ===Disease=== | |
| + | influenza A virus (IAV) infection | ||
===Chromosome=== | ===Chromosome=== | ||
12q24.31 | 12q24.31 | ||
| Line 16: | Line 15: | ||
===Ensembl ID=== | ===Ensembl ID=== | ||
ENSG00000248008 | ENSG00000248008 | ||
| − | === | + | |
| − | 25525793 | + | ===Characteristics=== |
| + | NRAV transcript is exactly 1,176 nt and contains a polyadenylated. <ref name="ref1" /> | ||
| + | |||
| + | ===Function=== | ||
| + | NRAV negatively regulates the initial transcription of multiple critical interferon-stimulated genes (ISGs), including IFITM3 and MxA, by affecting histone modification of these genes.<ref name="ref1" /> | ||
| + | NRAV plays a critical role in anti-IAV infection. <ref name="ref1" /> | ||
| + | |||
| + | ===Regulation=== | ||
| + | NRAV is dramatically downregulated during infection with several viruses, including a negative ssRNA virus Sendai virus (SeV), a dsRNA virus Muscovy Duck Reovirus (MDRV), and a DNA virus herpes simplex virus (HSV). <ref name="ref1" /> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.<ref name="ref1" /> | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> Ouyang J, Zhu X, Chen Y, Wei H, Chen Q, Chi X, Qi B, Zhang L, Zhao Y, Gao GF, Wang G, Chen JL. NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription. Cell Host Microbe. 2014 Nov 12;16(5):616-26. doi: 10.1016/j.chom.2014.10.001. Epub 2014 Nov12. PubMed PMID: 25525793. | ||
| + | </ref>(1) | ||
| + | </references> | ||
| + | |||
===Sequence=== | ===Sequence=== | ||
>gi|336391107|ref|NR_038854.1| Homo sapiens negative regulator of antiviral response (non-protein coding) (NRAV), long non-coding RNA | >gi|336391107|ref|NR_038854.1| Homo sapiens negative regulator of antiviral response (non-protein coding) (NRAV), long non-coding RNA | ||
<dnaseq>GCAGACCACAATGCACCGCTCACGGCGTCGGTTGCCCGGGCAATGGGCCGCACGCTACGAGGCCCACACACCCAGAAGGTGGAGCCCCGGCCGGGTTACGAGGACCACCCAGCTGTCTGGAGAGATGAAGAAAATGAGGTTCAAAGAGATGAAGTCTCTTGCCTAAAGTCAGTGACAGAAAGTGACAGAGCTGGGATGTGAATCCTGGTCTGACTCTACAGTCCCACATGGTAGATGGAACCTCCGAGCAACACCTAAACAAAAGGAGTTGATGCCTCCGAACAGAGTAATGTCGCTGGAGACACTAAGCATCGTCGGCCCCTGGCAGGAGCTCCCTAAATATGTGTTGGATGGATGGAAGAAAGGATGGATAGTTCAGAGTACTTCAGCCTTGATTCCTCCGCAACAGACACCTGAAACTTGACCCTACATTGGTTCTTGGCCATCGTGATCTTCCTTGGACAGAATCACCTTTCAGCTCCGGTCATCAGACTTTCCCAGGGCCCTCAGAAAGCCCTTCAGAGTTGTTACTCACAGGCAGGCTGAGGGATTCCTTACGGGGTCTGCAGCTCTCCTCACCTCATCCACAAGTAGGACCGTGGCCTGTTCCTCACTACTGCCCCAGGATCACTCTGTTCCCAGCCCAGTCCAGCAATCACTTGTCTAGCTTTCTGGAACCTTGAGTACTTTCTTGAACCATGAGTCCTGTGACCACCCTAGCAGCTCTAACCCTCCCTTATCTGAAAGGAAGTGTGAGGTGACCTTGCAGGTCCCAGAGTTGATTGAAGACCCCATCCAGAAAGAAGGCACCCTGTGGGAGAGATTGCAAGGCCTAGGTCTGAATCCGGAAGCTTCCACCCCATGGAGAAGGGCTGGCACCAGCCTGGGGCTGGCAGTGGAGCTGAGCTTTGGAGCCAAGGACTGTACTGCAGTGCAGGGAGAGTGAGGCCAGAAAGGCTGAGACAACTCAGGGAAAGAAAACCTCCCTTCTGGCTAATAGTCAAGCACCGCCTGAGTAGACCAACACTCTCCTGTCCACAGGGGCAGCAGATGAAGACACAACCAGAGAGGACTAACAGGCCCCCTCAGCTCTCAGTCAGAGGGCAGAGCAACACAGAATAGACATTAAAGGAACAGACTTTGAGGCCAGGCAGCCTTGGGTGTGCATCTGTCCCTACTAAGCCATGTGACATTAAACAAGTGAGTCCACCTCTCTGAGCCTCAGGTTCCTCATCTGTAAAATGGGGATTATAAGAGTTCTTGTTTCTCAGGGACAATGTGAGGATTAAGTGAGATGATACACATAGAGAATGTGGTGCAGTACTGGGCACATGGCAAAGATCAGTGATGCTAGCTACCACTTATCATTAGTGTTCCTGTAGACCAGGACTTCTCAACCTTGGCACTATTCACCTTTTGGGCCAGAAAGTTTTTTTTGTTGTTGTTGTGGGGAGCTGTCCTATGCATTTGAGGATGTTTAACAGCACCCCTGGCCTCTACCCACTAGATGCCAATCACACCACACCCCCAGTTTCAACAACCAAAAATGTCTGCAGATGGTGCCGAATGTCTTCTGGAGGGTGAAATCACTCCCCAGCAGTTGAAAAGCACCACCCTAAACAATCTGGACTGAATTTGAATGTCACAGATCCCAAGCTCACAGCTCCATGTAAAGGCCACAAGGCAGGCAGGCCTACTTGCAGATGAAGGAACGGAAAGAGCAACAATTACAGATCAAGCGGCTAGCTCCGGTGTAGACTAAGAGGCGGGATCTGTAGTCTGCTCTAGGAGCTAACAAGGCCTCTGTGACTCAGTAGGTGACCTCAGTGTCACTCTTTAATTATATGCAAAGTGGTCTTGTGTTAACTCTTAATTATTCTAGGGCTCCAAACAAGAA</dnaseq> | <dnaseq>GCAGACCACAATGCACCGCTCACGGCGTCGGTTGCCCGGGCAATGGGCCGCACGCTACGAGGCCCACACACCCAGAAGGTGGAGCCCCGGCCGGGTTACGAGGACCACCCAGCTGTCTGGAGAGATGAAGAAAATGAGGTTCAAAGAGATGAAGTCTCTTGCCTAAAGTCAGTGACAGAAAGTGACAGAGCTGGGATGTGAATCCTGGTCTGACTCTACAGTCCCACATGGTAGATGGAACCTCCGAGCAACACCTAAACAAAAGGAGTTGATGCCTCCGAACAGAGTAATGTCGCTGGAGACACTAAGCATCGTCGGCCCCTGGCAGGAGCTCCCTAAATATGTGTTGGATGGATGGAAGAAAGGATGGATAGTTCAGAGTACTTCAGCCTTGATTCCTCCGCAACAGACACCTGAAACTTGACCCTACATTGGTTCTTGGCCATCGTGATCTTCCTTGGACAGAATCACCTTTCAGCTCCGGTCATCAGACTTTCCCAGGGCCCTCAGAAAGCCCTTCAGAGTTGTTACTCACAGGCAGGCTGAGGGATTCCTTACGGGGTCTGCAGCTCTCCTCACCTCATCCACAAGTAGGACCGTGGCCTGTTCCTCACTACTGCCCCAGGATCACTCTGTTCCCAGCCCAGTCCAGCAATCACTTGTCTAGCTTTCTGGAACCTTGAGTACTTTCTTGAACCATGAGTCCTGTGACCACCCTAGCAGCTCTAACCCTCCCTTATCTGAAAGGAAGTGTGAGGTGACCTTGCAGGTCCCAGAGTTGATTGAAGACCCCATCCAGAAAGAAGGCACCCTGTGGGAGAGATTGCAAGGCCTAGGTCTGAATCCGGAAGCTTCCACCCCATGGAGAAGGGCTGGCACCAGCCTGGGGCTGGCAGTGGAGCTGAGCTTTGGAGCCAAGGACTGTACTGCAGTGCAGGGAGAGTGAGGCCAGAAAGGCTGAGACAACTCAGGGAAAGAAAACCTCCCTTCTGGCTAATAGTCAAGCACCGCCTGAGTAGACCAACACTCTCCTGTCCACAGGGGCAGCAGATGAAGACACAACCAGAGAGGACTAACAGGCCCCCTCAGCTCTCAGTCAGAGGGCAGAGCAACACAGAATAGACATTAAAGGAACAGACTTTGAGGCCAGGCAGCCTTGGGTGTGCATCTGTCCCTACTAAGCCATGTGACATTAAACAAGTGAGTCCACCTCTCTGAGCCTCAGGTTCCTCATCTGTAAAATGGGGATTATAAGAGTTCTTGTTTCTCAGGGACAATGTGAGGATTAAGTGAGATGATACACATAGAGAATGTGGTGCAGTACTGGGCACATGGCAAAGATCAGTGATGCTAGCTACCACTTATCATTAGTGTTCCTGTAGACCAGGACTTCTCAACCTTGGCACTATTCACCTTTTGGGCCAGAAAGTTTTTTTTGTTGTTGTTGTGGGGAGCTGTCCTATGCATTTGAGGATGTTTAACAGCACCCCTGGCCTCTACCCACTAGATGCCAATCACACCACACCCCCAGTTTCAACAACCAAAAATGTCTGCAGATGGTGCCGAATGTCTTCTGGAGGGTGAAATCACTCCCCAGCAGTTGAAAAGCACCACCCTAAACAATCTGGACTGAATTTGAATGTCACAGATCCCAAGCTCACAGCTCCATGTAAAGGCCACAAGGCAGGCAGGCCTACTTGCAGATGAAGGAACGGAAAGAGCAACAATTACAGATCAAGCGGCTAGCTCCGGTGTAGACTAAGAGGCGGGATCTGTAGTCTGCTCTAGGAGCTAACAAGGCCTCTGTGACTCAGTAGGTGACCTCAGTGTCACTCTTTAATTATATGCAAAGTGGTCTTGTGTTAACTCTTAATTATTCTAGGGCTCCAAACAAGAA</dnaseq> | ||
Latest revision as of 13:32, 14 January 2018
Contents
Annotated Information
Approved Symbol
NRAV (negative regulator of antiviral response (non-protein coding))
Previous Symbols
DYNLL1-AS1
NRAV Negatively Regulates the Expression of Several Critical ISGs[1]
Disease
influenza A virus (IAV) infection
Chromosome
12q24.31
RefSeq ID
NR_038854
OMIM ID
616207
Ensembl ID
ENSG00000248008
Characteristics
NRAV transcript is exactly 1,176 nt and contains a polyadenylated. [1]
Function
NRAV negatively regulates the initial transcription of multiple critical interferon-stimulated genes (ISGs), including IFITM3 and MxA, by affecting histone modification of these genes.[1] NRAV plays a critical role in anti-IAV infection. [1]
Regulation
NRAV is dramatically downregulated during infection with several viruses, including a negative ssRNA virus Sendai virus (SeV), a dsRNA virus Muscovy Duck Reovirus (MDRV), and a DNA virus herpes simplex virus (HSV). [1]
Labs working on this lncRNA
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ouyang J, Zhu X, Chen Y, Wei H, Chen Q, Chi X, Qi B, Zhang L, Zhao Y, Gao GF, Wang G, Chen JL. NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription. Cell Host Microbe. 2014 Nov 12;16(5):616-26. doi: 10.1016/j.chom.2014.10.001. Epub 2014 Nov12. PubMed PMID: 25525793.
Sequence
>gi|336391107|ref|NR_038854.1| Homo sapiens negative regulator of antiviral response (non-protein coding) (NRAV), long non-coding RNA
000001 GCAGACCACA ATGCACCGCT CACGGCGTCG GTTGCCCGGG CAATGGGCCG CACGCTACGA GGCCCACACA CCCAGAAGGT 000080
000081 GGAGCCCCGG CCGGGTTACG AGGACCACCC AGCTGTCTGG AGAGATGAAG AAAATGAGGT TCAAAGAGAT GAAGTCTCTT 000160
000161 GCCTAAAGTC AGTGACAGAA AGTGACAGAG CTGGGATGTG AATCCTGGTC TGACTCTACA GTCCCACATG GTAGATGGAA 000240
000241 CCTCCGAGCA ACACCTAAAC AAAAGGAGTT GATGCCTCCG AACAGAGTAA TGTCGCTGGA GACACTAAGC ATCGTCGGCC 000320
000321 CCTGGCAGGA GCTCCCTAAA TATGTGTTGG ATGGATGGAA GAAAGGATGG ATAGTTCAGA GTACTTCAGC CTTGATTCCT 000400
000401 CCGCAACAGA CACCTGAAAC TTGACCCTAC ATTGGTTCTT GGCCATCGTG ATCTTCCTTG GACAGAATCA CCTTTCAGCT 000480
000481 CCGGTCATCA GACTTTCCCA GGGCCCTCAG AAAGCCCTTC AGAGTTGTTA CTCACAGGCA GGCTGAGGGA TTCCTTACGG 000560
000561 GGTCTGCAGC TCTCCTCACC TCATCCACAA GTAGGACCGT GGCCTGTTCC TCACTACTGC CCCAGGATCA CTCTGTTCCC 000640
000641 AGCCCAGTCC AGCAATCACT TGTCTAGCTT TCTGGAACCT TGAGTACTTT CTTGAACCAT GAGTCCTGTG ACCACCCTAG 000720
000721 CAGCTCTAAC CCTCCCTTAT CTGAAAGGAA GTGTGAGGTG ACCTTGCAGG TCCCAGAGTT GATTGAAGAC CCCATCCAGA 000800
000801 AAGAAGGCAC CCTGTGGGAG AGATTGCAAG GCCTAGGTCT GAATCCGGAA GCTTCCACCC CATGGAGAAG GGCTGGCACC 000880
000881 AGCCTGGGGC TGGCAGTGGA GCTGAGCTTT GGAGCCAAGG ACTGTACTGC AGTGCAGGGA GAGTGAGGCC AGAAAGGCTG 000960
000961 AGACAACTCA GGGAAAGAAA ACCTCCCTTC TGGCTAATAG TCAAGCACCG CCTGAGTAGA CCAACACTCT CCTGTCCACA 001040
001041 GGGGCAGCAG ATGAAGACAC AACCAGAGAG GACTAACAGG CCCCCTCAGC TCTCAGTCAG AGGGCAGAGC AACACAGAAT 001120
001121 AGACATTAAA GGAACAGACT TTGAGGCCAG GCAGCCTTGG GTGTGCATCT GTCCCTACTA AGCCATGTGA CATTAAACAA 001200
001201 GTGAGTCCAC CTCTCTGAGC CTCAGGTTCC TCATCTGTAA AATGGGGATT ATAAGAGTTC TTGTTTCTCA GGGACAATGT 001280
001281 GAGGATTAAG TGAGATGATA CACATAGAGA ATGTGGTGCA GTACTGGGCA CATGGCAAAG ATCAGTGATG CTAGCTACCA 001360
001361 CTTATCATTA GTGTTCCTGT AGACCAGGAC TTCTCAACCT TGGCACTATT CACCTTTTGG GCCAGAAAGT TTTTTTTGTT 001440
001441 GTTGTTGTGG GGAGCTGTCC TATGCATTTG AGGATGTTTA ACAGCACCCC TGGCCTCTAC CCACTAGATG CCAATCACAC 001520
001521 CACACCCCCA GTTTCAACAA CCAAAAATGT CTGCAGATGG TGCCGAATGT CTTCTGGAGG GTGAAATCAC TCCCCAGCAG 001600
001601 TTGAAAAGCA CCACCCTAAA CAATCTGGAC TGAATTTGAA TGTCACAGAT CCCAAGCTCA CAGCTCCATG TAAAGGCCAC 001680
001681 AAGGCAGGCA GGCCTACTTG CAGATGAAGG AACGGAAAGA GCAAC
000081 GGAGCCCCGG CCGGGTTACG AGGACCACCC AGCTGTCTGG AGAGATGAAG AAAATGAGGT TCAAAGAGAT GAAGTCTCTT 000160
000161 GCCTAAAGTC AGTGACAGAA AGTGACAGAG CTGGGATGTG AATCCTGGTC TGACTCTACA GTCCCACATG GTAGATGGAA 000240
000241 CCTCCGAGCA ACACCTAAAC AAAAGGAGTT GATGCCTCCG AACAGAGTAA TGTCGCTGGA GACACTAAGC ATCGTCGGCC 000320
000321 CCTGGCAGGA GCTCCCTAAA TATGTGTTGG ATGGATGGAA GAAAGGATGG ATAGTTCAGA GTACTTCAGC CTTGATTCCT 000400
000401 CCGCAACAGA CACCTGAAAC TTGACCCTAC ATTGGTTCTT GGCCATCGTG ATCTTCCTTG GACAGAATCA CCTTTCAGCT 000480
000481 CCGGTCATCA GACTTTCCCA GGGCCCTCAG AAAGCCCTTC AGAGTTGTTA CTCACAGGCA GGCTGAGGGA TTCCTTACGG 000560
000561 GGTCTGCAGC TCTCCTCACC TCATCCACAA GTAGGACCGT GGCCTGTTCC TCACTACTGC CCCAGGATCA CTCTGTTCCC 000640
000641 AGCCCAGTCC AGCAATCACT TGTCTAGCTT TCTGGAACCT TGAGTACTTT CTTGAACCAT GAGTCCTGTG ACCACCCTAG 000720
000721 CAGCTCTAAC CCTCCCTTAT CTGAAAGGAA GTGTGAGGTG ACCTTGCAGG TCCCAGAGTT GATTGAAGAC CCCATCCAGA 000800
000801 AAGAAGGCAC CCTGTGGGAG AGATTGCAAG GCCTAGGTCT GAATCCGGAA GCTTCCACCC CATGGAGAAG GGCTGGCACC 000880
000881 AGCCTGGGGC TGGCAGTGGA GCTGAGCTTT GGAGCCAAGG ACTGTACTGC AGTGCAGGGA GAGTGAGGCC AGAAAGGCTG 000960
000961 AGACAACTCA GGGAAAGAAA ACCTCCCTTC TGGCTAATAG TCAAGCACCG CCTGAGTAGA CCAACACTCT CCTGTCCACA 001040
001041 GGGGCAGCAG ATGAAGACAC AACCAGAGAG GACTAACAGG CCCCCTCAGC TCTCAGTCAG AGGGCAGAGC AACACAGAAT 001120
001121 AGACATTAAA GGAACAGACT TTGAGGCCAG GCAGCCTTGG GTGTGCATCT GTCCCTACTA AGCCATGTGA CATTAAACAA 001200
001201 GTGAGTCCAC CTCTCTGAGC CTCAGGTTCC TCATCTGTAA AATGGGGATT ATAAGAGTTC TTGTTTCTCA GGGACAATGT 001280
001281 GAGGATTAAG TGAGATGATA CACATAGAGA ATGTGGTGCA GTACTGGGCA CATGGCAAAG ATCAGTGATG CTAGCTACCA 001360
001361 CTTATCATTA GTGTTCCTGT AGACCAGGAC TTCTCAACCT TGGCACTATT CACCTTTTGG GCCAGAAAGT TTTTTTTGTT 001440
001441 GTTGTTGTGG GGAGCTGTCC TATGCATTTG AGGATGTTTA ACAGCACCCC TGGCCTCTAC CCACTAGATG CCAATCACAC 001520
001521 CACACCCCCA GTTTCAACAA CCAAAAATGT CTGCAGATGG TGCCGAATGT CTTCTGGAGG GTGAAATCAC TCCCCAGCAG 001600
001601 TTGAAAAGCA CCACCCTAAA CAATCTGGAC TGAATTTGAA TGTCACAGAT CCCAAGCTCA CAGCTCCATG TAAAGGCCAC 001680
001681 AAGGCAGGCA GGCCTACTTG CAGATGAAGG AACGGAAAGA GCAAC