Difference between revisions of "HELLPAR"
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HELLP associated long non-coding RNA | HELLP associated long non-coding RNA | ||
===Synonyms=== | ===Synonyms=== | ||
| − | LINC-HELLP | + | LINC-HELLP, "long intergenic non-protein coding RNA associated with HELLP syndrome" |
===Chromosome=== | ===Chromosome=== | ||
12q23.2 | 12q23.2 | ||
| Line 18: | Line 18: | ||
===Characteristics=== | ===Characteristics=== | ||
| − | + | HELLPAR is a transcript of 205,012 bases and is localized in early placenta extravillous trophoblasts.<ref name="ref1" /> | |
| − | === | + | ===Function=== |
| − | + | HELLPAR is involved in 1 or more processes in the cell cycle, in which siRNA-mediated knockdown of the transcript leads to reduced activity of the G2/M phase of the cell cycle, while the G1/S phase shows an increase in activity.<ref name="ref1" /> | |
===Expression=== | ===Expression=== | ||
| − | + | HELLPAR has been found to be expressed in nucleus, perinuclear region, and cytoplasm, both in vitro — in the extravillous trophoblast cell line (SGHPL-5)and in vivo <ref name="ref1" />. | |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Latest revision as of 07:31, 19 September 2016
Contents
Annotated Information
Approved Symbol
HELLPAR
Approved Name
HELLP associated long non-coding RNA
Synonyms
LINC-HELLP, "long intergenic non-protein coding RNA associated with HELLP syndrome"
Chromosome
12q23.2
OMIM ID
614985
Ensembl ID
ENSG00000281344
pubmed IDs
23093777
Diseases
- HELLP syndrome
Characteristics
HELLPAR is a transcript of 205,012 bases and is localized in early placenta extravillous trophoblasts.[1]
Function
HELLPAR is involved in 1 or more processes in the cell cycle, in which siRNA-mediated knockdown of the transcript leads to reduced activity of the G2/M phase of the cell cycle, while the G1/S phase shows an increase in activity.[1]
Expression
HELLPAR has been found to be expressed in nucleus, perinuclear region, and cytoplasm, both in vitro — in the extravillous trophoblast cell line (SGHPL-5)and in vivo [1].
Labs working on this lncRNA
- Department of Clinical Chemistry and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.[1].
