Difference between revisions of "DINOL"
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| + | [[File:p53 is a DINO-binding protein.jpg|right|thumb|400px|'''p53 is a DINO-binding protein'''<ref name="ref1" />]] | ||
| + | [[File:Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis.jpg|right|thumb|400px|'''Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis'''<ref name="ref1" />]] | ||
==Annotated Information== | ==Annotated Information== | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | DINOL | + | DINOL (damage induced long noncoding RNA) |
| − | |||
| − | damage induced long noncoding RNA | ||
| − | |||
| − | |||
===Synonyms=== | ===Synonyms=== | ||
DINO | DINO | ||
===Chromosome=== | ===Chromosome=== | ||
6p21.2 | 6p21.2 | ||
| − | |||
| − | |||
| − | |||
| − | |||
===RefSeq(supplied by NCBI)=== | ===RefSeq(supplied by NCBI)=== | ||
NG_009364 | NG_009364 | ||
| − | === | + | ===Characteristic=== |
| − | + | DINO is a 951-base RNA transcribed divergently from CDKN1A.<ref name="ref1" /> | |
| + | DINO occupancies at p53 binding elements in 7 of 10 p53-target genes examined, including CDKN1A, GADD45A, and DDB2.<ref name="ref1" /> | ||
| + | |||
| + | ===Function=== | ||
| + | DINO encodes a p53-dependent DNA damage-induced transcript.<ref name="ref1" /> DINO stabilizes p53 and enhances regulation of its target genes.<ref name="ref1" /> | ||
| + | Loss of DINO abrogates DNA damage-induced gene regulation and cell cycle arrest.<ref name="ref1" /> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | *Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA. | ||
| + | *Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA. | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1">Schmitt, A.M., et al., An inducible long noncoding RNA amplifies DNA damage signaling. Nat Genet, 2016. 48(11): p. 1370-1376. | ||
| + | </ref>(1) | ||
| + | </references> | ||
Latest revision as of 08:32, 13 November 2017
p53 is a DINO-binding protein[1]
Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis[1]
Contents
Annotated Information
Approved Symbol
DINOL (damage induced long noncoding RNA)
Synonyms
DINO
Chromosome
6p21.2
RefSeq(supplied by NCBI)
NG_009364
Characteristic
DINO is a 951-base RNA transcribed divergently from CDKN1A.[1] DINO occupancies at p53 binding elements in 7 of 10 p53-target genes examined, including CDKN1A, GADD45A, and DDB2.[1]
Function
DINO encodes a p53-dependent DNA damage-induced transcript.[1] DINO stabilizes p53 and enhances regulation of its target genes.[1] Loss of DINO abrogates DNA damage-induced gene regulation and cell cycle arrest.[1]
Labs working on this lncRNA
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA.
- Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
