Difference between revisions of "TFAP2A-AS2"
(Created page with "==Annotated Information== ===Approved Symbol=== TFAP2A-AS2 ===Approved Name=== TFAP2A antisense RNA 2 ===Previous Symbols=== _ ===Synonyms=== HIPSTR ===Chromosome=== 6p24.3 ==...") |
Jiabao Cao (talk | contribs) (→Expression) |
||
| (9 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
| + | |||
==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | TFAP2A-AS2 | + | TFAP2A-AS2:TFAP2A antisense RNA 2 |
| − | === | + | |
| − | TFAP2A | + | HIPSTR.<ref name="ref1" /> |
| − | === | + | ===Characteristics=== |
| − | + | HIPSTR (Heterogeneously expressed from the Intronic Plus Strand of the TFAP2A-locus RNA) is a novel lncRNA gene in the developmentally regulated TFAP2A locus.<ref name="ref1" /> | |
| − | + | ||
| − | HIPSTR | + | ===Function=== |
| − | === | + | [[File:HIPSTR func.jpg|right|thumb|200px|'''Developmental genes are affected by HIPSTR knockdown in HEK293 and H1BP cells'''<ref name="ref1" />.]] |
| − | + | HIPSTR promoter is most active in undifferentiated cells, and depletion of HIPSTR in HEK293 and in pluripotent H1BP cells predominantly affects the genes involved in early organismal development and cell differentiation. | |
| − | = | + | |
| − | + | ===Regulation=== | |
| − | === | + | [[File:HIPSTR regulated.jpg|right|thumb|200px|'''TFAP2A can regulate HIPSTR promoter'''<ref name="ref1" />.]] |
| − | + | HIPSTR promoter can be stimulated by TFAP2A, but HIPSTR and TFAP2A are not consistently co-induced in developmental models in vitro.<ref name="ref1" /> | |
| − | === | + | |
| − | + | ===Expression=== | |
| − | == | + | [[File:HIPSTR expression.jpg|right|thumb|200px|'''The expression of TFAP2A-AS2'''<ref name="ref1" />.]] |
| − | + | HIPSTR is a bona fide antisense lncRNA. And HIPSTR has an evolutionarily conserved tissue-specific expression pattern, and that it is predominantly expressed in testis and placenta of mouse (Mouse ENCODE Project RNA-seq data) and of human. In addition, HIPSTR expression in the early human embryo is restricted to a subset of cells.<ref name="ref1" /> | |
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | *Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-000 São Paulo, SP, Brazil. | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Yunusov D, Anderson L, DaSilva LF, Wysocka J, Ezashi T, Roberts RM, | ||
| + | Verjovski-Almeida S. HIPSTR and thousands of lncRNAs are heterogeneously | ||
| + | expressed in human embryos, primordial germ cells and stable cell lines. Sci Rep. | ||
| + | 2016 Sep 8;6:32753. | ||
| + | </ref> | ||
| + | </references> | ||
Latest revision as of 15:35, 8 December 2017
Contents
Annotated Information
Name
TFAP2A-AS2:TFAP2A antisense RNA 2
HIPSTR.[1]
Characteristics
HIPSTR (Heterogeneously expressed from the Intronic Plus Strand of the TFAP2A-locus RNA) is a novel lncRNA gene in the developmentally regulated TFAP2A locus.[1]
Function
HIPSTR promoter is most active in undifferentiated cells, and depletion of HIPSTR in HEK293 and in pluripotent H1BP cells predominantly affects the genes involved in early organismal development and cell differentiation.
Regulation
HIPSTR promoter can be stimulated by TFAP2A, but HIPSTR and TFAP2A are not consistently co-induced in developmental models in vitro.[1]
Expression
HIPSTR is a bona fide antisense lncRNA. And HIPSTR has an evolutionarily conserved tissue-specific expression pattern, and that it is predominantly expressed in testis and placenta of mouse (Mouse ENCODE Project RNA-seq data) and of human. In addition, HIPSTR expression in the early human embryo is restricted to a subset of cells.[1]
Labs working on this lncRNA
- Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-000 São Paulo, SP, Brazil.
