Difference between revisions of "LINC00460"

From LncRNAWiki
Jump to: navigation, search
(Created page with "==Annotated Information== ===Approved Symbol=== LINC00460 ===Approved Name=== long intergenic non-protein coding RNA 460 ===Previous Symbols=== _ ===Synonyms=== _ ===Chromosom...")
 
 
(3 intermediate revisions by 2 users not shown)
Line 1: Line 1:
 
==Annotated Information==
 
==Annotated Information==
−
===Approved Symbol===
+
===Name===
−
LINC00460
+
Approved Symbol: LINC00460
−
===Approved Name===
+
 
−
long intergenic non-protein coding RNA 460
+
Approved Name: long intergenic non-protein coding RNA 460
−
===Previous Symbols===
+
 
−
_
+
RefSeq ID: NR_034119
−
===Synonyms===
+
 
−
_
+
LncBook transcript ID: HSALNT0289038
 +
 
 +
EnsemblID: ENSG00000233532
 +
 
 
===Chromosome===
 
===Chromosome===
 
13q33.2
 
13q33.2
−
===RefSeq ID===
+
 
−
NR_034119
+
===Characteristics===
−
===OMIM ID===
+
-
−
_
+
===Function===
−
===RefSeq(supplied by NCBI)===
+
 
−
NR_034119
+
* Loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression. LINC00460 promotes MMP-9 expression through targeting miR-539, acting as an oncogenic RNA in the meningioma malignancy and accelerating the proliferation and metastasis of meningeoma<ref name="ref2" />.
 +
 
 +
===Regulation===
 +
-
 +
===Diseases===
 +
Colorectal cancer<ref name="ref1" />.
 +
 
 +
Meningeoma<ref name="ref2" />.
 +
===Expression===
 +
[[File:LINC00460-exp.png|right|thumb|400px|LncRNA LINC00460 was over-expressed
 +
in meningeoma tissue and cells<ref name="ref2" />.]]
 +
LINC00460 expression level was significantly up-regulated in meningeoma tissues
 +
and malignant meningioma cell lines (IOMM-Lee, CH157-MN)<ref name="ref2" />.
 +
 
 +
{| class='wikitable' style="text-align:center"
 +
|-
 +
! | Experiment
 +
! | Forward primer
 +
! | Reverse primer
 +
|-
 +
| rowspan="1"|Quantitative real-time PCR
 +
| | 5'-AATGGTGGTAGGAGGGAGGA- 3'
 +
| | 5'-CAAGGGGAATGAACACGAGG- 3'<ref name="ref2" />
 +
|}
 +
 
 +
===Evolution===
 +
-
 
===pubmed IDs===
 
===pubmed IDs===
−
27591862
+
27591862, 29906745
 +
 
 +
===Sequence===
 +
>NR_034119.2 Homo sapiens long intergenic non-protein coding RNA 460 (LINC00460), transcript variant 1, long non-coding RNA
 +
<dnaseq>CTTCCTGCAGAAATCCTCCAGCCCTGTTAGAAATGCCTCAGCCAGGGGGACTCATCTCCTCAAACCTGGG
 +
GGACCGAGACCTATGAGAGGTCACAGCATGAGCCAGGACATCGGAGGTACCCAGACATTGTTATGAAACT
 +
CCGCATGTGCCCCTGGTGGACGCTGCTGGACCCAGCATGCACACTTCTCGGCTAAGAGTCACCCTGGATG
 +
AACCACCATTGCCAGCGGGGAGCATGTTGCAGCTTTCCCACGCAGTGGATGAGAACGAAGGTTACGACCA
 +
TTGTGTGGGAGGCGTCTGTGTAGCAATTGCTGGAATCACTTGTGGCATTGTAGAAAGACTGAGCGTGGGA
 +
AAGAAGACGCATTCTGAAGTCACCCCGATTTATGTTAAATTATCACCTTGACTACTGCTATAGAACGAAT
 +
GTTTATGTCCCCCACCCAAATTCGTATGCTAAGACCTAATAGCCAATAAGATAGTATTAATAGATGGGGC
 +
CTTTGGGAGGTGAGTGGCTCATGAGGGCAGAGTCCTCAAAACCAGATAAGTGCCCGAATAAAAGGGGCCC
 +
CAGAGAGATCCCTTGCACCGTCTACCATGTGAAGTGTAGAACACAGCGAGAAGGCCACCTATGAGCCAGA
 +
ACGTGGGCCCTCACCAGAACCCAGTTGTGCTGGCACCCTGATCCTGGACTTCCAGCCTCCAAAATGACGA
 +
CAAAGAAGTTTGTTTTTCCTGAGCCATCCACTTCAAAGTATTCTGTCATAGCTCCCCAAATAGACTAAGA
 +
CATCTACTTAACCTTGGTCAAACGTTTAACCTTGGAGTCCACGCCTCTGAAATGGTGACAATAACACTGT
 +
GTATTTCCTACTTTATGATCAGGATTAATAAATGTAATTTATTAATCAGAAATTAGTAATTTCTGATTAT
 +
TAA</dnaseq>
 +
 
 +
 
 +
==Labs working on this lncRNA==
 +
* Qingdao University, Qingdao, Shandong, 266003, China.
 +
==References==
 +
<references>
 +
<ref name="ref1">
 +
Wang R, Du L, Yang X, Jiang X, Duan W, Yan S, Xie Y, Zhu Y, Wang Q, Wang L, Yang Y, Wang C. Identification of long noncoding RNAs as potential novel diagnosis and prognosis biomarkers in colorectal cancer. J Cancer Res Clin Oncol. 2016 Nov;142(11):2291-301.
 +
</ref>(1)
 +
<ref name="ref2">
 +
Xing, H., Wang, S., Li, Q., Ma, Y., & Sun, P. Long noncoding RNA LINC00460 targets miR-539/MMP-9 to promote meningioma progression and metastasis. Biomed Pharmacother. 2018 Sep;105:677-682.
 +
</ref>(2)
 +
</references>

Latest revision as of 07:58, 13 August 2019

Annotated Information

Name

Approved Symbol: LINC00460

Approved Name: long intergenic non-protein coding RNA 460

RefSeq ID: NR_034119

LncBook transcript ID: HSALNT0289038

EnsemblID: ENSG00000233532

Chromosome

13q33.2

Characteristics

-

Function

  • Loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression. LINC00460 promotes MMP-9 expression through targeting miR-539, acting as an oncogenic RNA in the meningioma malignancy and accelerating the proliferation and metastasis of meningeoma[1].

Regulation

-

Diseases

Colorectal cancer[2].

Meningeoma[1].

Expression

LncRNA LINC00460 was over-expressed in meningeoma tissue and cells[1].

LINC00460 expression level was significantly up-regulated in meningeoma tissues and malignant meningioma cell lines (IOMM-Lee, CH157-MN)[1].

Experiment Forward primer Reverse primer
Quantitative real-time PCR 5'-AATGGTGGTAGGAGGGAGGA- 3' 5'-CAAGGGGAATGAACACGAGG- 3'[1]

Evolution

-

pubmed IDs

27591862, 29906745

Sequence

>NR_034119.2 Homo sapiens long intergenic non-protein coding RNA 460 (LINC00460), transcript variant 1, long non-coding RNA

000001 CTTCCTGCAG AAATCCTCCA GCCCTGTTAG AAATGCCTCA GCCAGGGGGA CTCATCTCCT CAAACCTGGG GGACCGAGAC 000080
000081 CTATGAGAGG TCACAGCATG AGCCAGGACA TCGGAGGTAC CCAGACATTG TTATGAAACT CCGCATGTGC CCCTGGTGGA 000160
000161 CGCTGCTGGA CCCAGCATGC ACACTTCTCG GCTAAGAGTC ACCCTGGATG AACCACCATT GCCAGCGGGG AGCATGTTGC 000240
000241 AGCTTTCCCA CGCAGTGGAT GAGAACGAAG GTTACGACCA TTGTGTGGGA GGCGTCTGTG TAGCAATTGC TGGAATCACT 000320
000321 TGTGGCATTG TAGAAAGACT GAGCGTGGGA AAGAAGACGC ATTCTGAAGT CACCCCGATT TATGTTAAAT TATCACCTTG 000400
000401 ACTACTGCTA TAGAACGAAT GTTTATGTCC CCCACCCAAA TTCGTATGCT AAGACCTAAT AGCCAATAAG ATAGTATTAA 000480
000481 TAGATGGGGC CTTTGGGAGG TGAGTGGCTC ATGAGGGCAG AGTCCTCAAA ACCAGATAAG TGCCCGAATA AAAGGGGCCC 000560
000561 CAGAGAGATC CCTTGCACCG TCTACCATGT GAAGTGTAGA ACACAGCGAG AAGGCCACCT ATGAGCCAGA ACGTGGGCCC 000640
000641 TCACCAGAAC CCAGTTGTGC TGGCACCCTG ATCCTGGACT TCCAGCCTCC AAAATGACGA CAAAGAAGTT TGTTTTTCCT 000720
000721 GAGCCATCCA CTTCAAAGTA TTCTGTCATA GCTCCCCAAA TAGACTAAGA CATCTACTTA ACCTTGGTCA AACGTTTAAC 000800
000801 CTTGGAGTCC ACGCCTCTGA AATGGTGACA ATAACACTGT GTATTTCCTA CTTTATGATC AGGATTAATA AATGTAATTT 000880
000881 ATTAATCAGA AATTAGTAAT TTCTGATTAT TAA


Labs working on this lncRNA

  • Qingdao University, Qingdao, Shandong, 266003, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Xing, H., Wang, S., Li, Q., Ma, Y., & Sun, P. Long noncoding RNA LINC00460 targets miR-539/MMP-9 to promote meningioma progression and metastasis. Biomed Pharmacother. 2018 Sep;105:677-682.
  2. ↑ Wang R, Du L, Yang X, Jiang X, Duan W, Yan S, Xie Y, Zhu Y, Wang Q, Wang L, Yang Y, Wang C. Identification of long noncoding RNAs as potential novel diagnosis and prognosis biomarkers in colorectal cancer. J Cancer Res Clin Oncol. 2016 Nov;142(11):2291-301.
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=LINC00460&oldid=1276491"