Difference between revisions of "LINP1"

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(Created page with "==Annotated Information== ===Approved Symbol=== LINP1 ===Approved Name=== lncRNA in non-homologous end joining pathway 1 ===Previous Symbols=== _ ===Synonyms=== _ ===Chromosom...")
 
 
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==Annotated Information==
 
==Annotated Information==
 +
[[File:Expression and genomic alteration of LINP1 in breast cancer.jpg|right|thumb|300px|'''Expression and genomic alteration of LINP1 in breast cancer'''<ref name="ref1" />]]
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[[File:LINP1 RNA associates with Ku80 and DNA-PKcs.jpg|right|thumb|300px|'''LINP1 RNA associates with Ku80 and DNA-PKcs'''<ref name="ref1" />]]
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[[File:LINP1 serves as a modular scaffold in the NHEJ pathway.jpg|right|thumb|300px|'''LINP1 serves as a modular scaffold in the NHEJ pathway'''<ref name="ref1" />]]
 
===Approved Symbol===
 
===Approved Symbol===
LINP1
+
LINP1 (lncRNA in non-homologous end joining pathway 10
===Approved Name===
 
lncRNA in non-homologous end joining pathway 1
 
===Previous Symbols===
 
_
 
===Synonyms===
 
_
 
 
===Chromosome===
 
===Chromosome===
 
10p14
 
10p14
 
===RefSeq ID===
 
===RefSeq ID===
 
NR_138480
 
NR_138480
===OMIM ID===
+
===Expression===
_
+
Compared with the non-basal lines, LINP1 has significantly higher expression level. <ref name="ref1" />
===RefSeq(supplied by NCBI)===
+
===Function===
_
+
LINP1 serves as a modular scaffold and uses different regions to interact with the two proteins Ku80 and DNA-PKcs which participate in the NHEJ pathway. <ref name="ref1" />
===pubmed IDs===
+
Suppressing LINP1 expression can impair DNA repair activity in vivo, which in turn sensitizes tumors to IR treatment.<ref name="ref1" />
27111890
+
===Regulation===
 +
LINP1 is activated by the EGF (RAS-MEK-JNK) pathway and repressed by the p53 signaling pathway. <ref name="ref1" />
 +
==Labs working on this lncRNA==
 +
* Center for Research on Reproduction &Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
 +
* Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
 +
==References==
 +
<references>
 +
<ref name="ref1"> Zhang, Y., et al., Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol, 2016. 23(6): p. 522-30.
 +
</ref>(1)
 +
</references>

Latest revision as of 14:23, 22 October 2017

Annotated Information

Expression and genomic alteration of LINP1 in breast cancer[1]
LINP1 RNA associates with Ku80 and DNA-PKcs[1]
LINP1 serves as a modular scaffold in the NHEJ pathway[1]

Approved Symbol

LINP1 (lncRNA in non-homologous end joining pathway 10

Chromosome

10p14

RefSeq ID

NR_138480

Expression

Compared with the non-basal lines, LINP1 has significantly higher expression level. [1]

Function

LINP1 serves as a modular scaffold and uses different regions to interact with the two proteins Ku80 and DNA-PKcs which participate in the NHEJ pathway. [1] Suppressing LINP1 expression can impair DNA repair activity in vivo, which in turn sensitizes tumors to IR treatment.[1]

Regulation

LINP1 is activated by the EGF (RAS-MEK-JNK) pathway and repressed by the p53 signaling pathway. [1]

Labs working on this lncRNA

  • Center for Research on Reproduction &Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Zhang, Y., et al., Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol, 2016. 23(6): p. 522-30.