Difference between revisions of "PINCR"
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| + | ''PINCR'' is a long noncoding RNA that regulates a subset of p53 target genes in human colorectal cancer cells through Matrin 3. | ||
| + | |||
==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | PINCR | + | ''PINCR'': p53-induced noncoding RNA (HGNC nomenclature) |
| − | === | + | |
| − | p53- | + | ===Characteristics=== |
| − | === | + | ''PINCR'' is six exons transcript of 2228 bp (GenBank) long noncoding RNA that is located on human cheomosome Xp11.3 <ref name="ref1" />. |
| − | + | ||
| − | === | + | ===Cellular Localization=== |
| − | + | PINCR is highly enriched in the nucleus <ref name="ref1" />. | |
| − | === | + | |
| − | + | ===Function=== | |
| − | === | + | [[File:PINCR.jpg|right|thumb|400px|'''''PINCR'' regulates the induction of select p53 target genes important for G1 arrest after DNA damage'''<ref name="ref1" />]] |
| − | + | PINCR is induced ~100-fold after DNA damage and exerts a prosurvival function in human colorectal cancer cells (CRC) in vitro and tumor growth in vivo <ref name="ref1" />. PINCR regulates a subset of p53 targets involved in G1 arrest and apoptosis (BTG2, RRM2B and GPX1) in human colorectal cancer cells by binding to Matrin 3, and plays an important role in p53-dependent G1 arrest <ref name="ref1" />. | |
| − | === | + | |
| − | + | ===Expression=== | |
| − | === | + | PINCR is induced ~100-fold after DNA damage <ref name="ref1" />. |
| − | + | ||
| − | === | + | ===Regulation=== |
| − | + | PINCR promoter contains p53RE, and PINCR is a direct target of p53 <ref name="ref1" />. | |
| + | |||
| + | ===Conservation=== | ||
| + | Mature PINCR transcript and the transcription start site are quite conserved among primates but poorly conserved between human and mouse <ref name="ref1" />. | ||
| + | |||
| + | ===Diseases=== | ||
| + | * Colorectal cancer <ref name="ref1" /> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States.<ref name="ref1" /> | ||
| + | * Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States; 3Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, United States.<ref name="ref1" /> | ||
| + | * Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States.<ref name="ref1" /> | ||
| + | * National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, United States.<ref name="ref1" /> | ||
| + | * Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.<ref name="ref1" /> | ||
| + | * Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States.<ref name="ref1" /> | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Chaudhary R, Gryder B, Woods WS, Subramanian M, Jones MF, Li XL et al. Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3[J]. Elife. 2017, 6:e23244. | ||
| + | </ref> | ||
| + | </references> | ||
| + | |||
| + | ===Sequence=== | ||
| + | >gi|101927501|ref|NR_110387.1| Homo sapiens p53-induced noncoding RNA (PINCR), long non-coding RNA | ||
| + | <dnaseq>ATTCAATCTGTGAGGTGGATGCGTGTTGGAAGGACCCCTTTTGGTTTCTTTTTGCTCAGAGCTTTCTTTT | ||
| + | AATAAATTCCGCTCTCCTCACCTTTCAATGTGTCCGTATGCCTAATTTTTCCTGGTCCTGTGACAAGAAC | ||
| + | CTGATTTTAGCTGAACTAAGGAGCGAAAGATCCTGGATCATTTTGGTGACCCATACTGGTACATGAGGAA | ||
| + | AGCTCCTATTCCAGATTCTCAGAGTATAGATTCTGACTGGATTACCCTGGTCCTTGAAGTATACCTAGGA | ||
| + | GATGGAATAACATTGTATAAGCATCCACGTTGTCATTAAGAGGAAAGAGTTTCCATTAAAACAGCAGGTC | ||
| + | ACAAAACCCTCCTGTGAGAGGAACCCTCTGTGGAAGAACAGAATATGTCACCCCAAAATATGAAGAATTG | ||
| + | TTGAGCTGAAGATGATTAAGAAGAAGCGGATGCAGGAAAGCTCTCTGCTCTCCCTCTATTTGCTTAAAAG | ||
| + | CAGGATAAACACTTACAAAGACTAAAGACGCCACAATCAAGAACTCAGAAGGGTAGAAGAAAAAGATAGT | ||
| + | TTCCCTTCCCTACACAGGTGTTGATCCCTTCATAAATATTATGCATGCTAAGCCCTATCTCAAGGTCTAC | ||
| + | ATCCAGGAGAACCCAACCTGCAACATTAAGTTACTGACTGTGCAAGAACCCTTTGATCACGTACCTTACA | ||
| + | GACCAAGATAAGTGAGGATGCCCATGTATAACCTGCTGTCTTTCTGGTCTCTTATGTTTTTGTACCAGAA | ||
| + | AGGGACAACTTTTTGGGTAACCATAGGTCTCTAGTATATCTGTGATTACAATAAAGATTTTTGATATACC | ||
| + | AAAACTGATGAACCAAAATTCCACTGAAATAGCGAGTAAATGGAGTTCTTTTATCCTTTGCAGTATACCA | ||
| + | GGGTGAACTTTTTACATGATTTCTTGCTCCAAAGGGAGAAGTGTTATGACAAAGTACATTTAAGGACCCT | ||
| + | AACTGATCACAGAAAAAATATTAATGGCATTGGGAAAAAAATGCAGACTAATGAATCCACTACTAAATTT | ||
| + | TATCTATCTTGTAGCTCTAAAATTGCACTGTTTAGAATACACTATGGTAGCCACTAGACATATGGCTACT | ||
| + | TGAACTTGAATTGGTTAAAATCAAAATTAAGAATTTAATTTCTCACTCACATTAGCCACATTTCAAGTGC | ||
| + | TCAACAGACACATGTGGCTAGTGTCTACCATATTGGACAGCATAGATTTAAAGCACATTTCCATCATTGC | ||
| + | AACACTGCAATATGGAGGATGTATCCTCAATACATTGATATTGCCCCCTCAAAATTCATAACCCCTAGAT | ||
| + | ATCTTATCTCTGTATGTGAGGATAGTGTATTAACTTGCACCTGGACTGAGATAGATAAATGCTTATCTCC | ||
| + | AGAGATGTCTGAAAGTCTGGTACTGACCCTTGTCTAAGATAAGGATGGAATGTGCTGGTTAATGATTTAT | ||
| + | ACTGTGCTATACAAAGTCCAAAATTCCTTTGGAGGTATCCTCTGCTGGCTTGTCTACATTGTTTAAGGAT | ||
| + | GGATAGGTTGATGGTTTGCACCTGCTTTAATCATTTACACATTCTGATTTTATTTGTGATCAGTGGAGGA | ||
| + | TAAAACCTTCAATAAACTTGTGTCTTAGCTTCCTTGATATTAAGATATCTTGCACATATCTTAGATTTTT | ||
| + | ATAATCTGAATGCAAAGCACATCCTTTGCAATTGAGAAAGGACTCTGTGAGCTGCTCCTGGATATGTGAA | ||
| + | ACCCCTCAGTGACTGACCGTATTTTCTTTCTTCTGCTGTACTTGCCCTTATTAAAGCCTTACATGTGAAG | ||
| + | TAAGTCCTTTCAATTGTCTGACTCCGGGTGATTGTTATACCCTTTGATATAGTTTGGATATTTGTGCCTT | ||
| + | CCAAATCTCATGTTGAAATGCGATCCCCTATGTTGGAGGTGGAGCCTAGTAGGAGGTGTTAGGGTCACGG | ||
| + | GAATGGATCCCTGATGAATGGCTTGGTACACAGTAATGAGTGAGTTTGTGCTTTATTAGTTACTGTGAGA | ||
| + | TTTACTTGGTAAAAAGAGCCTGGCAACTCCTCCCTCTCCCTTGCTCCCTCTCTTGCCATGTGACATGCTT | ||
| + | GCTCCAGCTGCACCTTTTGCCACAATTGTAAGCTTTGTGAGTCCCTCAACAGAAGCTGAGCAAATGCTGG | ||
| + | CACCATGCTTCTTGTACAGCCTACAGAACTGTGAACCAAATAAAACTTTTATTTTTAT</dnaseq> | ||
Latest revision as of 05:31, 26 November 2018
PINCR is a long noncoding RNA that regulates a subset of p53 target genes in human colorectal cancer cells through Matrin 3.
Contents
Annotated Information
Name
PINCR: p53-induced noncoding RNA (HGNC nomenclature)
Characteristics
PINCR is six exons transcript of 2228 bp (GenBank) long noncoding RNA that is located on human cheomosome Xp11.3 [1].
Cellular Localization
PINCR is highly enriched in the nucleus [1].
Function
PINCR regulates the induction of select p53 target genes important for G1 arrest after DNA damage[1]
PINCR is induced ~100-fold after DNA damage and exerts a prosurvival function in human colorectal cancer cells (CRC) in vitro and tumor growth in vivo [1]. PINCR regulates a subset of p53 targets involved in G1 arrest and apoptosis (BTG2, RRM2B and GPX1) in human colorectal cancer cells by binding to Matrin 3, and plays an important role in p53-dependent G1 arrest [1].
Expression
PINCR is induced ~100-fold after DNA damage [1].
Regulation
PINCR promoter contains p53RE, and PINCR is a direct target of p53 [1].
Conservation
Mature PINCR transcript and the transcription start site are quite conserved among primates but poorly conserved between human and mouse [1].
Diseases
- Colorectal cancer [1]
Labs working on this lncRNA
- Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States.[1]
- Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States; 3Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, United States.[1]
- Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States.[1]
- National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, United States.[1]
- Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.[1]
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 Chaudhary R, Gryder B, Woods WS, Subramanian M, Jones MF, Li XL et al. Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3[J]. Elife. 2017, 6:e23244.
Sequence
>gi|101927501|ref|NR_110387.1| Homo sapiens p53-induced noncoding RNA (PINCR), long non-coding RNA
000001 ATTCAATCTG TGAGGTGGAT GCGTGTTGGA AGGACCCCTT TTGGTTTCTT TTTGCTCAGA GCTTTCTTTT AATAAATTCC 000080
000081 GCTCTCCTCA CCTTTCAATG TGTCCGTATG CCTAATTTTT CCTGGTCCTG TGACAAGAAC CTGATTTTAG CTGAACTAAG 000160
000161 GAGCGAAAGA TCCTGGATCA TTTTGGTGAC CCATACTGGT ACATGAGGAA AGCTCCTATT CCAGATTCTC AGAGTATAGA 000240
000241 TTCTGACTGG ATTACCCTGG TCCTTGAAGT ATACCTAGGA GATGGAATAA CATTGTATAA GCATCCACGT TGTCATTAAG 000320
000321 AGGAAAGAGT TTCCATTAAA ACAGCAGGTC ACAAAACCCT CCTGTGAGAG GAACCCTCTG TGGAAGAACA GAATATGTCA 000400
000401 CCCCAAAATA TGAAGAATTG TTGAGCTGAA GATGATTAAG AAGAAGCGGA TGCAGGAAAG CTCTCTGCTC TCCCTCTATT 000480
000481 TGCTTAAAAG CAGGATAAAC ACTTACAAAG ACTAAAGACG CCACAATCAA GAACTCAGAA GGGTAGAAGA AAAAGATAGT 000560
000561 TTCCCTTCCC TACACAGGTG TTGATCCCTT CATAAATATT ATGCATGCTA AGCCCTATCT CAAGGTCTAC ATCCAGGAGA 000640
000641 ACCCAACCTG CAACATTAAG TTACTGACTG TGCAAGAACC CTTTGATCAC GTACCTTACA GACCAAGATA AGTGAGGATG 000720
000721 CCCATGTATA ACCTGCTGTC TTTCTGGTCT CTTATGTTTT TGTACCAGAA AGGGACAACT TTTTGGGTAA CCATAGGTCT 000800
000801 CTAGTATATC TGTGATTACA ATAAAGATTT TTGATATACC AAAACTGATG AACCAAAATT CCACTGAAAT AGCGAGTAAA 000880
000881 TGGAGTTCTT TTATCCTTTG CAGTATACCA GGGTGAACTT TTTACATGAT TTCTTGCTCC AAAGGGAGAA GTGTTATGAC 000960
000961 AAAGTACATT TAAGGACCCT AACTGATCAC AGAAAAAATA TTAATGGCAT TGGGAAAAAA ATGCAGACTA ATGAATCCAC 001040
001041 TACTAAATTT TATCTATCTT GTAGCTCTAA AATTGCACTG TTTAGAATAC ACTATGGTAG CCACTAGACA TATGGCTACT 001120
001121 TGAACTTGAA TTGGTTAAAA TCAAAATTAA GAATTTAATT TCTCACTCAC ATTAGCCACA TTTCAAGTGC TCAACAGACA 001200
001201 CATGTGGCTA GTGTCTACCA TATTGGACAG CATAGATTTA AAGCACATTT CCATCATTGC AACACTGCAA TATGGAGGAT 001280
001281 GTATCCTCAA TACATTGATA TTGCCCCCTC AAAATTCATA ACCCCTAGAT ATCTTATCTC TGTATGTGAG GATAGTGTAT 001360
001361 TAACTTGCAC CTGGACTGAG ATAGATAAAT GCTTATCTCC AGAGATGTCT GAAAGTCTGG TACTGACCCT TGTCTAAGAT 001440
001441 AAGGATGGAA TGTGCTGGTT AATGATTT
000081 GCTCTCCTCA CCTTTCAATG TGTCCGTATG CCTAATTTTT CCTGGTCCTG TGACAAGAAC CTGATTTTAG CTGAACTAAG 000160
000161 GAGCGAAAGA TCCTGGATCA TTTTGGTGAC CCATACTGGT ACATGAGGAA AGCTCCTATT CCAGATTCTC AGAGTATAGA 000240
000241 TTCTGACTGG ATTACCCTGG TCCTTGAAGT ATACCTAGGA GATGGAATAA CATTGTATAA GCATCCACGT TGTCATTAAG 000320
000321 AGGAAAGAGT TTCCATTAAA ACAGCAGGTC ACAAAACCCT CCTGTGAGAG GAACCCTCTG TGGAAGAACA GAATATGTCA 000400
000401 CCCCAAAATA TGAAGAATTG TTGAGCTGAA GATGATTAAG AAGAAGCGGA TGCAGGAAAG CTCTCTGCTC TCCCTCTATT 000480
000481 TGCTTAAAAG CAGGATAAAC ACTTACAAAG ACTAAAGACG CCACAATCAA GAACTCAGAA GGGTAGAAGA AAAAGATAGT 000560
000561 TTCCCTTCCC TACACAGGTG TTGATCCCTT CATAAATATT ATGCATGCTA AGCCCTATCT CAAGGTCTAC ATCCAGGAGA 000640
000641 ACCCAACCTG CAACATTAAG TTACTGACTG TGCAAGAACC CTTTGATCAC GTACCTTACA GACCAAGATA AGTGAGGATG 000720
000721 CCCATGTATA ACCTGCTGTC TTTCTGGTCT CTTATGTTTT TGTACCAGAA AGGGACAACT TTTTGGGTAA CCATAGGTCT 000800
000801 CTAGTATATC TGTGATTACA ATAAAGATTT TTGATATACC AAAACTGATG AACCAAAATT CCACTGAAAT AGCGAGTAAA 000880
000881 TGGAGTTCTT TTATCCTTTG CAGTATACCA GGGTGAACTT TTTACATGAT TTCTTGCTCC AAAGGGAGAA GTGTTATGAC 000960
000961 AAAGTACATT TAAGGACCCT AACTGATCAC AGAAAAAATA TTAATGGCAT TGGGAAAAAA ATGCAGACTA ATGAATCCAC 001040
001041 TACTAAATTT TATCTATCTT GTAGCTCTAA AATTGCACTG TTTAGAATAC ACTATGGTAG CCACTAGACA TATGGCTACT 001120
001121 TGAACTTGAA TTGGTTAAAA TCAAAATTAA GAATTTAATT TCTCACTCAC ATTAGCCACA TTTCAAGTGC TCAACAGACA 001200
001201 CATGTGGCTA GTGTCTACCA TATTGGACAG CATAGATTTA AAGCACATTT CCATCATTGC AACACTGCAA TATGGAGGAT 001280
001281 GTATCCTCAA TACATTGATA TTGCCCCCTC AAAATTCATA ACCCCTAGAT ATCTTATCTC TGTATGTGAG GATAGTGTAT 001360
001361 TAACTTGCAC CTGGACTGAG ATAGATAAAT GCTTATCTCC AGAGATGTCT GAAAGTCTGG TACTGACCCT TGTCTAAGAT 001440
001441 AAGGATGGAA TGTGCTGGTT AATGATTT