Difference between revisions of "KTN1-AS1"
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | KTN1-AS1 | + | KTN1-AS1:KTN1 antisense RNA 1 |
| − | + | ||
| − | KTN1 antisense RNA 1 | + | KTN1-AS1, MYCLo-3<ref name="ref1" /> |
| − | = | + | ===Function=== |
| − | + | [[File:MYCLo-3 func.jpg|right|thumb|200px|'''Effect of MYCLos knockdown on cell proliferation and cell cycle progression'''<ref name="ref1" />.]] | |
| − | === | + | The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. <ref name="ref1" /> |
| − | MYCLo-3 | + | |
| − | === | + | ===Expression=== |
| − | + | The expression of KTN1-AS1 is upregulated by MYC and dysregulated in CRC(colorectal cancer).<ref name="ref1" /> | |
| − | === | + | ===Diseases=== |
| − | + | Colorectal cancer<ref name="ref1" /> | |
| − | === | + | ===Sequence=== |
| − | + | >NR_027123.1 Homo sapiens KTN1 antisense RNA 1 (KTN1-AS1), long non-coding RNA | |
| − | + | <dnaseq>GCGCTCCGGTACTCGCTGCTCGCGGCTGGCCGGCTCGGGATTCCGGGCTTTCTTCCCGAGACCGCGTCCC | |
| − | + | CCAGCTGGGCCGAAGGTGGACGCTCAGGGGCTGGAGGCTCAGCGGAATCCCCTGCGTTCAGTAGCCCCGC | |
| − | == | + | TCTCCCCTGTCCCGAAGGATTACTCTGCCCCTCAGCGGTTCCAGTGCCCTCAAAGCAATCTGTCTCTGAA |
| − | + | GTACTGGCTATCTTCTGAGCGTGTGCCAGAAGATCCAGCTTTGTTGAAAAGCGAAGCCGTTAGTCCCTTA | |
| − | == | + | ATACAAAGGATCAGGGATAGCAGAAATGAAAGTATAATGGAAGCAGCTGGAGGATTCCAGGTCCACTTTC |
| − | + | ACCCAAGTAATGGAGACGGAAGGTTCATCGAAACTTCTTCAGCTGCAGATCTAGAAGTCATTAGCTATTC | |
| + | TAGCAAAGTATCTGTCACAGAAAGGTGCTTCATAAAGGTCTGCACTGTGCTCTTTTGACCTGTGTCTTCA | ||
| + | AGCATGTGCTGTCATAACAGATTAAAGATGACTGAAAATTATCTGCCACTCATTGCGTGAAAGGTGGGAT | ||
| + | CTGTAGACCTCCCTCTTGAATTTGGGAGGGTTCTGTGACTGCTGTGACCAATGAATATGGCAGAAGTGAC | ||
| + | GCTTTGCCAACTTCTGGGTCCAGGCTATACGAGACAGGCAGTTCCACTCACTGTCTCTTAGATCCATGTA | ||
| + | AAAAGTTCATCTACCCTGCTGGAAAAACCATGTAGAGAGGCCCTGAGACTACATTGGGTGGGAGAGGGGC | ||
| + | TCAGCTGCACCATCTTCCAACTGTCCCCATCAAGATGACAGAAATATAAATGAAGCCTTCTTGAACTCCA | ||
| + | GACCATCCATGCTACAAGCTAAATGCCACCAAGCGACCCCAGTTAATACCATGTGGAGCAAAAATATCAC | ||
| + | TTAACCAAGCACTGCCTGAGTTTCTGACCCCACAGAATTCTGACCCCATACAAATAAAATAATTTTTGTA | ||
| + | ATTTTTTATAATTCGTCATGTAATAGATAAATGGAACAGCCTTCTTCCAGTCTTTTAAATAGCTGCAAGA | ||
| + | AATCTTATTCAAGCAGAAGGAAGTTTCTACTTTGTTCATACAGTCTCAAGACATCCCTGGAGCCTTTCAA | ||
| + | GGGAAATTTGGGCAGAAGTAGGTAGAGAGGTAAAGCTATTATGTAACATTACTTAACATGATTAAAACCA | ||
| + | CCTTAATGTCTCCCATCCTCAAAGGCTGCCAGTGAATTGGAAATTAATGGATTAAATGAGGACAGAGAAA | ||
| + | CTAGTATTTGTGCATATGCACTGTGCCAGGTATTTAACGTATCTTAGCTCATGTGGTCTTCGAAACAACC | ||
| + | CCATATTGTAGTATCAGGCTCACACGGGTAACTAACTAGTGCAAAGACACAAGGCTCACAAACTGCTACT | ||
| + | TGACCCTAGAGCTCTTTGACTCCGATTCCCATGTACGTGCCCCAATACCATGTTGACTCCCAAGGTGTAA | ||
| + | ATCTTCAGGTATACAAACTATTAAAATGTGAATTTTCATTTA | ||
| + | |||
| + | </dnaseq> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | *Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX (TK); Department of Molecular Virology, Immunology and Medical Genetics (TK, YJJ, RC, ET, HA, CMC), Department of Neurological Surgery (SHK), and Department of Anesthesiology (ET), Wexner Medical Center, The Ohio State University, OH; School of Biological Sciences, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul, Republic of Korea (JHL); State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China (YP); School of Life Sciences and Biotechnology, Korea University, Republic of Korea (SHK). | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Kim T, Jeon YJ, Cui R, Lee JH, Peng Y, Kim SH, Tili E, Alder H, Croce CM. Role | ||
| + | of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. | ||
| + | J Natl Cancer Inst. 2015 Feb 6;107(4). | ||
| + | </ref> | ||
| + | </references> | ||
Latest revision as of 12:33, 11 January 2018
Contents
Annotated Information
Name
KTN1-AS1:KTN1 antisense RNA 1
KTN1-AS1, MYCLo-3[1]
Function
Effect of MYCLos knockdown on cell proliferation and cell cycle progression[1].
The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. [1]
Expression
The expression of KTN1-AS1 is upregulated by MYC and dysregulated in CRC(colorectal cancer).[1]
Diseases
Colorectal cancer[1]
Sequence
>NR_027123.1 Homo sapiens KTN1 antisense RNA 1 (KTN1-AS1), long non-coding RNA
000001 GCGCTCCGGT ACTCGCTGCT CGCGGCTGGC CGGCTCGGGA TTCCGGGCTT TCTTCCCGAG ACCGCGTCCC CCAGCTGGGC 000080
000081 CGAAGGTGGA CGCTCAGGGG CTGGAGGCTC AGCGGAATCC CCTGCGTTCA GTAGCCCCGC TCTCCCCTGT CCCGAAGGAT 000160
000161 TACTCTGCCC CTCAGCGGTT CCAGTGCCCT CAAAGCAATC TGTCTCTGAA GTACTGGCTA TCTTCTGAGC GTGTGCCAGA 000240
000241 AGATCCAGCT TTGTTGAAAA GCGAAGCCGT TAGTCCCTTA ATACAAAGGA TCAGGGATAG CAGAAATGAA AGTATAATGG 000320
000321 AAGCAGCTGG AGGATTCCAG GTCCACTTTC ACCCAAGTAA TGGAGACGGA AGGTTCATCG AAACTTCTTC AGCTGCAGAT 000400
000401 CTAGAAGTCA TTAGCTATTC TAGCAAAGTA TCTGTCACAG AAAGGTGCTT CATAAAGGTC TGCACTGTGC TCTTTTGACC 000480
000481 TGTGTCTTCA AGCATGTGCT GTCATAACAG ATTAAAGATG ACTGAAAATT ATCTGCCACT CATTGCGTGA AAGGTGGGAT 000560
000561 CTGTAGACCT CCCTCTTGAA TTTGGGAGGG TTCTGTGACT GCTGTGACCA ATGAATATGG CAGAAGTGAC GCTTTGCCAA 000640
000641 CTTCTGGGTC CAGGCTATAC GAGACAGGCA GTTCCACTCA CTGTCTCTTA GATCCATGTA AAAAGTTCAT CTACCCTGCT 000720
000721 GGAAAAACCA TGTAGAGAGG CCCTGAGACT ACATTGGGTG GGAGAGGGGC TCAGCTGCAC CATCTTCCAA CTGTCCCCAT 000800
000801 CAAGATGACA GAAATATAAA TGAAGCCTTC TTGAACTCCA GACCATCCAT GCTACAAGCT AAATGCCACC AAGCGACCCC 000880
000881 AGTTAATACC ATGTGGAGCA AAAATATCAC TTAACCAAGC ACTGCCTGAG TTTCTGACCC CACAGAATTC TGACCCCATA 000960
000961 CAAATAAAAT AATTTTTGTA ATTTTTTATA ATTCGTCATG TAATAGATAA ATGGAACAGC CTTCTTCCAG TCTTTTAAAT 001040
001041 AGCTGCAAGA AATCTTATTC AAGCAGAAGG AAGTTTCTAC TTTGTTCATA CAGTCTCAAG ACATCCCTGG AGCCTTTCAA 001120
001121 GGGAAATTTG GGCAGAAGTA GGTAGAGAGG TAAAGCTATT ATGTAACATT ACTTAACATG ATTAAAACCA CCTTAATGTC 001200
001201 TCCCATCCTC AAAGGCTGCC AGTGAATTGG AAATTAATGG ATTAAATGAG GACAGAGAAA CTAGTATTTG TGCATATGCA 001280
001281 CTGTGCCAGG TATTTAACGT ATCTTAGCTC ATGTGGTCTT CGAAACAACC CCATATTGTA GTATCAGGCT CACACGGGTA 001360
001361 ACTAACTAGT GCAAAGACAC AAGGCTCACA AACTGCTACT TGACCCTAGA GCTCTTTGAC TCCGATTCCC ATGTACGTGC 001440
001441 CCCAATACCA TGTTGACTCC CAAGGTGTAA ATCTTCAGGT ATACAAACTA TTAAAATGTG AATTTTCATT TA
000081 CGAAGGTGGA CGCTCAGGGG CTGGAGGCTC AGCGGAATCC CCTGCGTTCA GTAGCCCCGC TCTCCCCTGT CCCGAAGGAT 000160
000161 TACTCTGCCC CTCAGCGGTT CCAGTGCCCT CAAAGCAATC TGTCTCTGAA GTACTGGCTA TCTTCTGAGC GTGTGCCAGA 000240
000241 AGATCCAGCT TTGTTGAAAA GCGAAGCCGT TAGTCCCTTA ATACAAAGGA TCAGGGATAG CAGAAATGAA AGTATAATGG 000320
000321 AAGCAGCTGG AGGATTCCAG GTCCACTTTC ACCCAAGTAA TGGAGACGGA AGGTTCATCG AAACTTCTTC AGCTGCAGAT 000400
000401 CTAGAAGTCA TTAGCTATTC TAGCAAAGTA TCTGTCACAG AAAGGTGCTT CATAAAGGTC TGCACTGTGC TCTTTTGACC 000480
000481 TGTGTCTTCA AGCATGTGCT GTCATAACAG ATTAAAGATG ACTGAAAATT ATCTGCCACT CATTGCGTGA AAGGTGGGAT 000560
000561 CTGTAGACCT CCCTCTTGAA TTTGGGAGGG TTCTGTGACT GCTGTGACCA ATGAATATGG CAGAAGTGAC GCTTTGCCAA 000640
000641 CTTCTGGGTC CAGGCTATAC GAGACAGGCA GTTCCACTCA CTGTCTCTTA GATCCATGTA AAAAGTTCAT CTACCCTGCT 000720
000721 GGAAAAACCA TGTAGAGAGG CCCTGAGACT ACATTGGGTG GGAGAGGGGC TCAGCTGCAC CATCTTCCAA CTGTCCCCAT 000800
000801 CAAGATGACA GAAATATAAA TGAAGCCTTC TTGAACTCCA GACCATCCAT GCTACAAGCT AAATGCCACC AAGCGACCCC 000880
000881 AGTTAATACC ATGTGGAGCA AAAATATCAC TTAACCAAGC ACTGCCTGAG TTTCTGACCC CACAGAATTC TGACCCCATA 000960
000961 CAAATAAAAT AATTTTTGTA ATTTTTTATA ATTCGTCATG TAATAGATAA ATGGAACAGC CTTCTTCCAG TCTTTTAAAT 001040
001041 AGCTGCAAGA AATCTTATTC AAGCAGAAGG AAGTTTCTAC TTTGTTCATA CAGTCTCAAG ACATCCCTGG AGCCTTTCAA 001120
001121 GGGAAATTTG GGCAGAAGTA GGTAGAGAGG TAAAGCTATT ATGTAACATT ACTTAACATG ATTAAAACCA CCTTAATGTC 001200
001201 TCCCATCCTC AAAGGCTGCC AGTGAATTGG AAATTAATGG ATTAAATGAG GACAGAGAAA CTAGTATTTG TGCATATGCA 001280
001281 CTGTGCCAGG TATTTAACGT ATCTTAGCTC ATGTGGTCTT CGAAACAACC CCATATTGTA GTATCAGGCT CACACGGGTA 001360
001361 ACTAACTAGT GCAAAGACAC AAGGCTCACA AACTGCTACT TGACCCTAGA GCTCTTTGAC TCCGATTCCC ATGTACGTGC 001440
001441 CCCAATACCA TGTTGACTCC CAAGGTGTAA ATCTTCAGGT ATACAAACTA TTAAAATGTG AATTTTCATT TA
Labs working on this lncRNA
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX (TK); Department of Molecular Virology, Immunology and Medical Genetics (TK, YJJ, RC, ET, HA, CMC), Department of Neurological Surgery (SHK), and Department of Anesthesiology (ET), Wexner Medical Center, The Ohio State University, OH; School of Biological Sciences, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul, Republic of Korea (JHL); State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China (YP); School of Life Sciences and Biotechnology, Korea University, Republic of Korea (SHK).