Difference between revisions of "CERNA2"

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''CERNA2''- a long noncoding RNA expressed in all four major, clinicopathologic subtypes of ovarian malignancy
 +
 
==Annotated Information==
 
==Annotated Information==
 +
===Approved Symbol===
 +
''CERNA2''
 
===Name===
 
===Name===
−
CERNA2:competing endogenous lncRNA 2 for microRNA let-7b
+
''CERNA2'':competing endogenous lncRNA 2 for microRNA let-7b
 +
HOST2<ref name="ref1" />
  
−
HOST2<ref name="ref1" />
 
 
===Characteristics===
 
===Characteristics===
−
HOST2 is a novel member of the family of long non-coding mRNA-like genes, 2.9 kb in length, without an obvious open reading frame (ORF)<ref name="ref1" />
+
''CERNA2'' is a novel member of the family of long non-coding mRNA-like genes, 2.9 kb in length, without an obvious open reading frame (ORF).<ref name="ref1" />
  
 
===Function===
 
===Function===
−
Specific and high-expression of HOST2 promotes EOC(epithelial ovarian cancer) cell migration, invasion and proliferation.
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''CERNA2'' promotes tumor cell migration, invasion and proliferation in epithelial ovarian cancer <ref name="ref1" />.
−
HOST2 knockdown releases more let-7b, leading to heightened let-7bfunction, and the HOST2/let-7b axis contributes to regulating tumor cell growth and biological functions.<ref name="ref1" />
+
''CERNA2'' harbors a let-7b binding site and inhibits let-7b functions post-transcriptionally, thus regulating cell growth and motility <ref name="ref1" />.
−
LncRNA-HOST2 can promote cell proliferation, migration and invasion and inhibit cell apoptosis in human  hepatocellular carcinoma (HCC) cell line SMMC-7721<ref name="ref1" />
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In human  hepatocellular carcinoma (HCC) cell line SMMC-7721, ''CERNA2'' is found to promote cell proliferation, migration and invasion, and inhibit cell apoptosis <ref name="ref2" />.
  
 
===Regulation===
 
===Regulation===
−
Let-7b repressed HOST2 expression in EOC<ref name="ref1" />
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Let-7b can bind to ''CERNA2'' and repress its expression in EOC <ref name="ref1" />.
  
 
===Disease===
 
===Disease===
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Ovarian cancer<ref name="ref1" />
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*Hepatocellular carcinoma<ref name="ref2" />
 +
*Ovarian cancer<ref name="ref1" />
  
−
Hepatocellular carcinoma<ref name="ref2" />
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===Expression===
 +
''CERNA2'' is obviously upregulated in an EOC-derived cell line, OVCAR-3, compared with the other tested cell lines, including MKN28, Huh-7, HepG2, McF-7, DU145, A357, MG63, Hep-2, ARK2 and HeLa <ref name="ref1" />.
 +
In hepatocellular carcinoma (HCC) tissues, the expression of ''CERNA2'' is up-regulated by approximately 2–10 times <ref name="ref2" />
  
−
===Expression===
+
 
−
HOST2 is obviously upregulated in an EOC-derived cell line, OVCAR-3, compared with the other tested cell lines, including MKN28, Huh-7, HepG2, McF-7, DU145, A357, MG63, Hep-2, ARK2 and HeLa<ref name="ref1" />
+
==Labs working on this lncRNA==
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The expression of LncRNA-HOST2 in hepatocellular carcinoma (HCC) tissues is up-regulated by approximately 2–10 times and is not related to gender, age or level of animal protein factor (APF) (all P>0.05), while correlated with the size, quantity, distant metastasis and  American Joint Committee on Cancer (AJCC) staging and differentiation degree of the tumour <ref name="ref2" />
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*Chinese PLA General Hospital, Beijing 100853, China Changhai Hospital of Second Military Medical University, Shanghai 200433, China.
 +
*Department of Hepatobiliary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050051, P.R. China.
 +
 
 +
==References==
 +
<references>
 +
<ref name="ref1"> Gao Y, Meng H, Liu S, Hu J, Zhang Y, Jiao T, Liu Y, Ou J, Wang D, Yao L, Liu S, Hui N. LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b. Hum Mol Genet. 2015 Feb1;24(3):841-52.
 +
</ref>(1)
 +
<ref name="ref2"> Liu RT, Cao JL, Yan CQ, Wang Y, An CJ, Lv HT. Effects of LncRNA-HOST2 on cell proliferation, migration, invasion and apoptosis of human hepatocellular carcinoma cell line SMMC-7721. Biosci Rep. 2017 Apr 20;37(2).
 +
</ref>(2)
 +
</references>
  
 
===Sequence===
 
===Sequence===
−
>NR_134505.1 Homo sapiens competing endogenous lncRNA 2 for microRNA let-7b (CERNA2), long non-coding RNA
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>gi|642934|ref|134505.1| Homo sapiens competing endogenous lncRNA 2 for microRNA let-7b (CERNA2), long non-coding RNA
 
<dnaseq>CAGTAGCTTGCCGATGCTCCCAGCTGAATAAAGCCCTGCCTTCTACAACTCAGTGTCTGAGAGGTTTTGT
 
<dnaseq>CAGTAGCTTGCCGATGCTCCCAGCTGAATAAAGCCCTGCCTTCTACAACTCAGTGTCTGAGAGGTTTTGT
 
CTGCGGCTCACCCTGCTACATTTCTTGGTTCCCTGACTGGGAAACGAGGTGACTGACGGATGGCCGAGGC
 
CTGCGGCTCACCCTGCTACATTTCTTGGTTCCCTGACTGGGAAACGAGGTGACTGACGGATGGCCGAGGC
Line 53: Line 69:
 
GTGTTGTGAGCCCTTAAAAGGGACAGAAATTGAGTATTTGGGGAGCTTGGATTTTAAGGCAGTAGCTTGC
 
GTGTTGTGAGCCCTTAAAAGGGACAGAAATTGAGTATTTGGGGAGCTTGGATTTTAAGGCAGTAGCTTGC
 
TGATGCTCCCAGCTGAATAAAGCCCTTCCTTCCACAAAAAAAAAAAAAAAAAAAA</dnaseq>
 
TGATGCTCCCAGCTGAATAAAGCCCTTCCTTCCACAAAAAAAAAAAAAAAAAAAA</dnaseq>
−
 
−
 
−
==Labs working on this lncRNA==
 
−
*Chinese PLA General Hospital, Beijing 100853, China Changhai Hospital of Second Military Medical University, Shanghai 200433, China.<ref name="ref1" />
 
−
*Department of Hepatobiliary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050051, P.R. China.<ref name="ref2" />
 
−
==References==
 
−
<references>
 
−
<ref name="ref1">
 
−
Gao Y, Meng H, Liu S, Hu J, Zhang Y, Jiao T, Liu Y, Ou J, Wang D, Yao L, Liu
 
−
S, Hui N. LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian
 
−
cancer through a mechanism involving microRNA let-7b. Hum Mol Genet. 2015 Feb
 
−
1;24(3):841-52.
 
−
</ref>
 
−
<ref name="ref2">
 
−
Liu RT, Cao JL, Yan CQ, Wang Y, An CJ, Lv HT. Effects of LncRNA-HOST2 on cell
 
−
proliferation, migration, invasion and apoptosis of human hepatocellular
 
−
carcinoma cell line SMMC-7721. Biosci Rep. 2017 Apr 20;37(2).
 
−
</ref>
 
−
</references>
 

Latest revision as of 05:24, 16 November 2018

CERNA2- a long noncoding RNA expressed in all four major, clinicopathologic subtypes of ovarian malignancy

Annotated Information

Approved Symbol

CERNA2

Name

CERNA2:competing endogenous lncRNA 2 for microRNA let-7b HOST2[1]

Characteristics

CERNA2 is a novel member of the family of long non-coding mRNA-like genes, 2.9 kb in length, without an obvious open reading frame (ORF).[1]

Function

CERNA2 promotes tumor cell migration, invasion and proliferation in epithelial ovarian cancer [1]. CERNA2 harbors a let-7b binding site and inhibits let-7b functions post-transcriptionally, thus regulating cell growth and motility [1]. In human hepatocellular carcinoma (HCC) cell line SMMC-7721, CERNA2 is found to promote cell proliferation, migration and invasion, and inhibit cell apoptosis [2].

Regulation

Let-7b can bind to CERNA2 and repress its expression in EOC [1].

Disease

  • Hepatocellular carcinoma[2]
  • Ovarian cancer[1]

Expression

CERNA2 is obviously upregulated in an EOC-derived cell line, OVCAR-3, compared with the other tested cell lines, including MKN28, Huh-7, HepG2, McF-7, DU145, A357, MG63, Hep-2, ARK2 and HeLa [1]. In hepatocellular carcinoma (HCC) tissues, the expression of CERNA2 is up-regulated by approximately 2–10 times [2]


Labs working on this lncRNA

  • Chinese PLA General Hospital, Beijing 100853, China Changhai Hospital of Second Military Medical University, Shanghai 200433, China.
  • Department of Hepatobiliary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050051, P.R. China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gao Y, Meng H, Liu S, Hu J, Zhang Y, Jiao T, Liu Y, Ou J, Wang D, Yao L, Liu S, Hui N. LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b. Hum Mol Genet. 2015 Feb1;24(3):841-52.
  2. ↑ 2.0 2.1 2.2 Liu RT, Cao JL, Yan CQ, Wang Y, An CJ, Lv HT. Effects of LncRNA-HOST2 on cell proliferation, migration, invasion and apoptosis of human hepatocellular carcinoma cell line SMMC-7721. Biosci Rep. 2017 Apr 20;37(2).

Sequence

>gi|642934|ref|134505.1| Homo sapiens competing endogenous lncRNA 2 for microRNA let-7b (CERNA2), long non-coding RNA

000001 CAGTAGCTTG CCGATGCTCC CAGCTGAATA AAGCCCTGCC TTCTACAACT CAGTGTCTGA GAGGTTTTGT CTGCGGCTCA 000080
000081 CCCTGCTACA TTTCTTGGTT CCCTGACTGG GAAACGAGGT GACTGACGGA TGGCCGAGGC AGCCCCTTAG GCGGCTTAGG 000160
000161 CCTGCCCTGT GGAGCATCCG TGAGGGGAAC TCCGGCCAGC CTGAGTGACG TGATCCAAAG AGCGCTCCCG GGTAGGCAAT 000240
000241 TGCCCCAATG GAACGCCTTG CCAGAGCAGC GTGTAGCAGG CCCCCACGGA AGATTAACAC AGTGGCTGAA CACCAGGAAG 000320
000321 GAACTGGCAC TTGGAGTCCG GACATCTACA ACTTGGCCCA ACCACCGAGA CCACCCTTAA ACATCAGTAG ACTGGGAGCT 000400
000401 GTACGTGGAT GGGAGCAGCT TTGCCAACCC TTGCAAAGTG ACTCTGAAGA AGACGACAAG CCTTGTTCCG GTCACACCCG 000480
000481 GAAGCTGACT GGTTCACGCA TGGCCGAAGC ATGAGGAAAC TCATCGCGGG AATAATTTTC CTTAAAATTT GGACTTGTAC 000560
000561 AGTAAGGACT TCAACTGACC TTATGCTAAG CTGCCTGATC AGTGGACAGG TAGCTGTGTA ATTGGACAGG TAGCTGTGTA 000640
000641 ATTGGCACCA TTAAGCCATC TTTCTTCTTA CTGCCAATAA AAACAGGTGA ACTTCTAGGC TTCCTAGTCT ATGCTTCCCG 000720
000721 TGAAAAATGA AGCATAGCCA TAGGTGATTA GAAAATAATG AATGGCCCCC TGAAAGAATC ATACAATACT ATAGACCCAC 000800
000801 CACTTAGGCA CAAGATGGCT CATGAGGATA TCGAACCCCC ATCTACATGC TCAACCGAAT CATACAGTTA CAAGCGGTTT 000880
000881 TAGAAATTAT TACTAATAAA ACCGGTCAAG CCTTGACTGT TCTTGCCCGG CAAGAGACTC TGATGAGAAA TTTTATCTAT 000960
000961 CAAAATATAC TAGCTCTTGA CTACTTGCTA GCAGCTGAAG GAGAAGTTTG TAAAAAATTT AACCTTACTA ATTGTTGTCT 001040
001041 ACACATAAAT GATTAAGGGC AAGTAGTTAA AAATATAGTT AAAGATATAA CAAAACTGGC ACATGTACCC ATGCAAGTGT 001120
001121 GGCATGGGCT CAATCCGGGA GCCATGTTTG CAAATTGGTT CCCAGCAATG AAAAAATTTA AAACTCTTAT AATAAGAGTA 001200
001201 ATAATAGTAA TAGAAACCTG CTTACTGCTC CTTTGTCTGA TACCTGTATT TCTCCAAATG ATAAAAAACT TTGTCACGAC 001280
001281 CTTAGTTCAC CAAAATGCTT TAGCAGAAGC ATACTATATA AATCACTATC AATCTATTGC ACAAAAAGAC ATAAGTAGCA 001360
001361 AAAATAAGAC TCAGAACTCC CACTAATAAA AACTGAGAGT CTCAAAGGGG GGAAATGAGG GAAGAGAGAG AGACCCTCTC 001440
001441 ATATTGTTTT ATATTGTTTT ATACTCAGTA CCTCTTTTAA GAAAAAGTGA CAAGGAAGT