Difference between revisions of "LINC01857"
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===Characteristics=== | ===Characteristics=== | ||
| − | The long non-coding RNA transcript AC079767.4 (Ensembl ID ENST00000429730) is encoded by gene AC079767.4 (Ensembl ID ENSG00000224137)<ref name="ref1" /> | + | The long non-coding RNA transcript AC079767.4 (Ensembl ID ENST00000429730) is encoded by gene AC079767.4 (Ensembl ID ENSG00000224137)<ref name="ref1" />. |
| − | |||
===Function=== | ===Function=== | ||
| − | + | AC079767.4 is a highly susceptible lncRNA in tuberculosis. Haplotype [ACAC], representing four AC079767.4 variants in Western Chinese Han population, is found to slightly decrease TB risk (p = 0.045) <ref name="ref1" />. | |
| − | |||
===Diseases=== | ===Diseases=== | ||
Tuberculosis<ref name="ref1" /> | Tuberculosis<ref name="ref1" /> | ||
| + | |||
===Expression=== | ===Expression=== | ||
| − | + | AC079767.4 transcript is down-regulated in both the active TB group and latent tuberculosis infection (LTBI) group compared with healthy controls, and its expression level is elevated in the LTBI group when compared to the active TB group <ref name="ref1" />. | |
| − | in both the active TB group and LTBI group compared with healthy controls, and its expression level is elevated in the LTBI group when compared to the active TB group<ref name="ref1" /> | ||
===Sequence=== | ===Sequence=== | ||
| Line 35: | Line 33: | ||
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1"> | + | <ref name="ref1">Zhao Z, Zhang M, Ying J, Hu X, Zhang J, Zhou Y, Zhou Y, Song X, Ying B.Significance of genetic polymorphisms in long non-coding RNA AC079767.4 in tuberculosis susceptibility and clinical phenotype in Western Chinese Han population. Sci Rep. 2017 Apr 19;7(1):965.</ref> |
| − | Zhao Z, Zhang M, Ying J, Hu X, Zhang J, Zhou Y, Zhou Y, Song X, Ying B. | ||
| − | Significance of genetic polymorphisms in long non-coding RNA AC079767.4 in | ||
| − | tuberculosis susceptibility and clinical phenotype in Western Chinese Han | ||
| − | population. Sci Rep. 2017 Apr 19;7(1):965. | ||
| − | </ref> | ||
</references> | </references> | ||
Latest revision as of 07:59, 15 August 2017
Contents
Annotated Information
Name
LINC01857：long intergenic non-protein coding RNA 1857
AC079767.4[1]
Characteristics
The long non-coding RNA transcript AC079767.4 (Ensembl ID ENST00000429730) is encoded by gene AC079767.4 (Ensembl ID ENSG00000224137)[1].
Function
AC079767.4 is a highly susceptible lncRNA in tuberculosis. Haplotype [ACAC], representing four AC079767.4 variants in Western Chinese Han population, is found to slightly decrease TB risk (p = 0.045) [1].
Diseases
Tuberculosis[1]
Expression
AC079767.4 transcript is down-regulated in both the active TB group and latent tuberculosis infection (LTBI) group compared with healthy controls, and its expression level is elevated in the LTBI group when compared to the active TB group [1].
Sequence
>NR_135567.1 Homo sapiens long intergenic non-protein coding RNA 1857 (LINC01857), transcript variant 2, long non-coding RNA
000001 GAGGATGCAG TGTTCATGAA AGCAAACACT GGGCCCTCAC CAGGCAACAA ACCTGCTGGT GCCTTCATCT TGGACTTCCC 000080
000081 AGCCTTCGGA ACTATGGAGC CCGCACTCTC CAGTTCATCA CCACCCCAGC ATCCCTACTC TTGCATCTAA CAGTTTCCGC 000160
000161 TATTTTGCAC CACCTGCCTG GCCCTTATGG GCAACTCAAG GAAGAAAGGA AAGAAGAGAT AGAGGAAAAA TGGATTCAAC 000240
000241 AAATGAAAGT GTTCTTTCTG ACTACTGCTG TGTTTACAAA CATTTTAATC ATCAAAACAT GCTTTATTTG ATAGAAAGAT 000320
000321 CAAATCTGCC TTTGTAAAAC AAGAGACTAT TTTAATCATT AAGACAACAC ACATGTTTGA TTTGGAGGCG TGTTCTCATT 000400
000401 CAAAACCTTG CAAAATATAA TTTCTTCTTG TCTGGGA
000081 AGCCTTCGGA ACTATGGAGC CCGCACTCTC CAGTTCATCA CCACCCCAGC ATCCCTACTC TTGCATCTAA CAGTTTCCGC 000160
000161 TATTTTGCAC CACCTGCCTG GCCCTTATGG GCAACTCAAG GAAGAAAGGA AAGAAGAGAT AGAGGAAAAA TGGATTCAAC 000240
000241 AAATGAAAGT GTTCTTTCTG ACTACTGCTG TGTTTACAAA CATTTTAATC ATCAAAACAT GCTTTATTTG ATAGAAAGAT 000320
000321 CAAATCTGCC TTTGTAAAAC AAGAGACTAT TTTAATCATT AAGACAACAC ACATGTTTGA TTTGGAGGCG TGTTCTCATT 000400
000401 CAAAACCTTG CAAAATATAA TTTCTTCTTG TCTGGGA
Labs working on this lncRNA
- Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.
