Difference between revisions of "FLNC-AS1"

Latest revision as of 03:19, 30 August 2017

FLNC-AS1:FLNC antisense RNA 1

ENST00000469965 ^[1]

ENST00000469965 is a FLNC(filamin C) natural antisense lncRNA ^[1].

ENST00000469965 is significantly downregulated in SiHa/ΔNp63αstable cell lines ^[1].

Cervical squamous cancers ^[1]

Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B, Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017 Aug;96:114-122.

@@ Line 4: / Line 4: @@
 FLNC-AS1:FLNC antisense RNA 1
-ENST00000447565 <ref name="ref1" />
+ENST00000469965 <ref name="ref1" />
 ===Characteristics===
-ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA. <ref name="ref1" />
+ENST00000469965 is a FLNC(filamin C) natural antisense lncRNA <ref name="ref1" />.
+===Expression===
+ENST00000469965 is significantly downregulated in SiHa/ΔNp63αstable cell lines <ref name="ref1" />.
-===Function===
-Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA which might contribute to inhibit the degradation of LIF mRNA mediated by other RNAs.<ref name="ref1" />
-===Regulation===
-The expression ofΔNp63α can directly inhibitLIF mRNA transcription and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS.<ref name="ref1" />
 ===Diseases===
-Cervical squamous cancers<ref name="ref1" />
+Cervical squamous cancers <ref name="ref1" />
-===Expression===
-ENST00000447565 is significantly downregulated expression  in SiHa/ΔNp63αstable cell lines.
+===Sequence===
-In addition, Lnc-LIF-AS is also shown gradually up-regulated with the increase of ΔNp63α siRNAs. <ref name="ref1" />
 ==Labs working on this lncRNA==