Difference between revisions of "LINC02231"

From LncRNAWiki
Jump to: navigation, search
 
(One intermediate revision by the same user not shown)
Line 4: Line 4:
 
LINC02231:long intergenic non-protein coding RNA 2231
 
LINC02231:long intergenic non-protein coding RNA 2231
  
−
RP11-766N7.4<ref name="ref1" />
+
RP11-766N7.4 <ref name="ref1" />
 +
 
 
===Characteristics===
 
===Characteristics===
−
Long noncoding RNA RP11-766N7.4, originally discovered by Ensembl GenomeBioinformatics, is located on the reversed strand in 12q14.3 region with a length of 447 bps.<ref name="ref1" />
+
Long noncoding RNA RP11-766N7.4 is located on the reversed strand in 12q14.3 region with a length of 447 bps <ref name="ref1" />.
  
 
===Function===
 
===Function===
−
The long noncoding RNA RP11-766N7.4 expression is negatively correlated with lymph node metastasis(P=0.000) and tumor stage (P=0.034).
+
RP11-766N7.4 expression is negatively correlated with lymph node metastasis and tumor stage, and RP11-766N7.4 inhibites cellular migration and invasion by suppressing EMT (Epithelial-Mesenchymal Transition) process <ref name="ref1" />.
−
Long noncoding RNA RP11-766N7.4 knockdown promotes cellular migration and invasion via inducing EMT process, and overexpression of long noncoding RNA RP11-766N7.4 inhibites cellular migration and invasion by suppressing EMT process.<ref name="ref1" />
 
−
===Diseases===
 
−
Esophageal squamous cell carcinoma<ref name="ref1" />
 
  
 
===Expression===
 
===Expression===
−
RT-qPCR results show that the long noncoding RNA RP11-766N7.4 expression level is remarkably lower in 50 Esophageal squamous cell carcinoma(ESCC) tissue samples compared with the corresponding adjacent tissues.<ref name="ref1" />
+
RP11-766N7.4 is remarkably down-regulated in Esophageal squamous cell carcinoma(ESCC) tissue samples compared with the paired adjacent tissues <ref name="ref1" />.
 +
 
 +
===Diseases===
 +
Esophageal squamous cell carcinoma <ref name="ref1" />
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==

Latest revision as of 07:56, 1 September 2017

Annotated Information

Name

LINC02231:long intergenic non-protein coding RNA 2231

RP11-766N7.4 [1]

Characteristics

Long noncoding RNA RP11-766N7.4 is located on the reversed strand in 12q14.3 region with a length of 447 bps [1].

Function

RP11-766N7.4 expression is negatively correlated with lymph node metastasis and tumor stage, and RP11-766N7.4 inhibites cellular migration and invasion by suppressing EMT (Epithelial-Mesenchymal Transition) process [1].

Expression

RP11-766N7.4 is remarkably down-regulated in Esophageal squamous cell carcinoma(ESCC) tissue samples compared with the paired adjacent tissues [1].

Diseases

Esophageal squamous cell carcinoma [1]

Labs working on this lncRNA

  • Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, PR China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Yao GL, Pan CF, Xu H, Wei K, Liu B, Zhai R, Chen YJ. Long noncoding RNA RP11-766N7.4 functions as a tumor suppressor by regulating epithelial-mesenchymal transition in esophageal squamous cell carcinoma. Biomed Pharmacother. 2017 Apr;88:778-785.
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=LINC02231&oldid=1273507"