Difference between revisions of "HDHD5-AS1"
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==Annotated Information== | ==Annotated Information== | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | HDHD5-AS1 | + | HDHD5-AS1: HDHD5 antisense RNA 1 |
===Previous Symbols=== | ===Previous Symbols=== | ||
| − | + | CECR4, CECR5-AS1 | |
===Synonyms=== | ===Synonyms=== | ||
NCRNA00017 | NCRNA00017 | ||
===Chromosome=== | ===Chromosome=== | ||
22q11.1 | 22q11.1 | ||
| + | [[File: Genomic structure of the genes in the CES critical region (CESCR).jpg|right|thumb|400px|'''Genomic structure of the genes in the CES critical region (CESCR).''' <ref name="ref1" />.]] | ||
===RefSeq ID=== | ===RefSeq ID=== | ||
NR_024483 | NR_024483 | ||
===Characteristics=== | ===Characteristics=== | ||
| − | + | CECR4 is adjacent to the human CES (Cat Eye Syndrome) critical region (CESCR), and at least 99 bp of overlap exists between CECR4 and the proximally adjacent gene, CECR5, which is transcribed in the opposite direction <ref name="ref1" />. | |
| − | |||
| − | |||
===Conservation=== | ===Conservation=== | ||
The sequences of exon 1 of HDHD5-AS1 is conserved in human and mouse <ref name="ref1" />. | The sequences of exon 1 of HDHD5-AS1 is conserved in human and mouse <ref name="ref1" />. | ||
| + | |||
| + | ===Function=== | ||
| + | CECR4 is adjacent to the human Cat Eye Syndrome critical region, and it may be involved in Cat Eye Syndrome <ref name="ref1" />. | ||
===Disease=== | ===Disease=== | ||
| − | + | Cat Eye Syndrome <ref name="ref1" /> | |
===Expression=== | ===Expression=== | ||
| Line 35: | Line 37: | ||
| | Testis | | | Testis | ||
|- | |- | ||
| − | | rowspan="1"|CECR4 | + | | rowspan="1"|CECR4 (HDHD5-AS1) |
| |cDNA 321686 | | |cDNA 321686 | ||
| | 7 | | | 7 | ||
| − | | | Adult heart and skeletal muscle, all fetal | + | | | Adult heart and skeletal muscle, all fetal tissues tested |
|- | |- | ||
| rowspan="2"|CECR3 | | rowspan="2"|CECR3 | ||
| |cDNA | | |cDNA | ||
| | 2.4 and 3.7 | | | 2.4 and 3.7 | ||
| − | | | 2.4 kb—predominantly in lung; | + | | | 2.4 kb—predominantly in lung; 3.7 kg—weakly in all tissues |
|} | |} | ||
| Line 51: | Line 53: | ||
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1"> Footz, T.K., et al. | + | <ref name="ref1"> Footz, T.K., Brinkman-Mills, P., Banting, G.S., Maier, S.A., Riazi, M.A., Bridgland, L., Hu, S., Birren, B., Minoshima, S., Shimizu, N. et al. (2001) Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. Genome Res, 11, 1053-1070.</ref>(1) |
| − | </ref>(1) | ||
Latest revision as of 08:34, 28 September 2017
Contents
Annotated Information
Approved Symbol
HDHD5-AS1: HDHD5 antisense RNA 1
Previous Symbols
CECR4, CECR5-AS1
Synonyms
NCRNA00017
Chromosome
22q11.1
.jpg)
Genomic structure of the genes in the CES critical region (CESCR). [1].
RefSeq ID
NR_024483
Characteristics
CECR4 is adjacent to the human CES (Cat Eye Syndrome) critical region (CESCR), and at least 99 bp of overlap exists between CECR4 and the proximally adjacent gene, CECR5, which is transcribed in the opposite direction [1].
Conservation
The sequences of exon 1 of HDHD5-AS1 is conserved in human and mouse [1].
Function
CECR4 is adjacent to the human Cat Eye Syndrome critical region, and it may be involved in Cat Eye Syndrome [1].
Disease
Cat Eye Syndrome [1]
Expression
| Gene name | Probe used | Size of transcript(s) in kb | Tissues showing expression |
|---|---|---|---|
| CECR8 | cDNA 1840041 | 1.4 | Testis |
| CECR4 (HDHD5-AS1) | cDNA 321686 | 7 | Adult heart and skeletal muscle, all fetal tissues tested |
| CECR3 | cDNA | 2.4 and 3.7 | 2.4 kb—predominantly in lung; 3.7 kg—weakly in all tissues |
Labs working on this lncRNA
- Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada. [1]
References
<references>
[1](1)- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Footz, T.K., Brinkman-Mills, P., Banting, G.S., Maier, S.A., Riazi, M.A., Bridgland, L., Hu, S., Birren, B., Minoshima, S., Shimizu, N. et al. (2001) Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. Genome Res, 11, 1053-1070.
