Difference between revisions of "KRT7-AS"
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==Annotated Information== | ==Annotated Information== | ||
| + | [[File:Expression pattern of KRT7-AS and KRT7 mRNAs in cell lines and tissues.jpg|right|thumb|300px|'''Expression pattern of KRT7-AS and KRT7 mRNAs in cell lines and tissues.'''<ref name="ref1"/>]] | ||
| + | [[File:Regulatory function of KRT7-AS overexpression to KRT7.jpg|right|thumb|300px|'''Regulatory function of KRT7-AS overexpression to KRT7.'''<ref name="ref1"/>]] | ||
| + | [[File:Regulatory function of KRT7 mRNA downregulation to KRT7-AS and the rescue effect of KRT7-AS overexpression in KRT7 mRNA-downregulated cells.jpg|right|thumb|300px|'''Regulatory function of KRT7 mRNA downregulation to KRT7-AS and the rescue effect of KRT7-AS overexpression in KRT7 mRNA-downregulated cells.'''<ref name="ref1"/>]] | ||
| + | |||
===Approved Symbol=== | ===Approved Symbol=== | ||
KRT7-AS (KRT7 antisense RNA 1) | KRT7-AS (KRT7 antisense RNA 1) | ||
| + | |||
===Chromosome=== | ===Chromosome=== | ||
12q13.13 | 12q13.13 | ||
| + | |||
===RefSeq=== | ===RefSeq=== | ||
NG_012296 | NG_012296 | ||
| + | |||
===Characteristics=== | ===Characteristics=== | ||
| − | KRT7-AS shares a 213-nucleotide-long region with the seventh exon of KRT7.<ref name="ref1"/> | + | KRT7-AS is localized to the nucleus and it shares a 213-nucleotide-long region with the seventh exon of KRT7.<ref name="ref1"/> |
===Expression=== | ===Expression=== | ||
| − | + | KRT7-AS levels are much lower than KRT7 mRNA levels in the same samples. In MKN28 and KATOIII cells, KRT7-AS is 61 and 41 fold lower than KRT7 mRNA (P<0.01). | |
| − | = | + | |
| − | + | ===Function=== | |
| + | KRT7-AS and KRT7 mRNA form a duplex RNA-RNA structure at their overlapping region, which can increase KRT7 mRNA stability and protect KRT7 mRNA from degradation.<ref name="ref1"/> | ||
| + | The overexpressed KRT7-AS in gastric cancer cells leads to increased proliferation and migration.<ref name="ref1"/> | ||
| + | |||
===Disease=== | ===Disease=== | ||
| − | gastric cancer | + | gastric cancer <ref name="ref1"/> |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
| Line 22: | Line 32: | ||
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1"> | + | <ref name="ref1">Huang, B., et al., Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression. Oncogene, 2016. 35(37): p. 4927-36. |
</ref>(1) | </ref>(1) | ||
</references> | </references> | ||
Latest revision as of 01:33, 16 October 2017
Contents
Annotated Information
Expression pattern of KRT7-AS and KRT7 mRNAs in cell lines and tissues.[1]
Regulatory function of KRT7-AS overexpression to KRT7.[1]
Regulatory function of KRT7 mRNA downregulation to KRT7-AS and the rescue effect of KRT7-AS overexpression in KRT7 mRNA-downregulated cells.[1]
Approved Symbol
KRT7-AS (KRT7 antisense RNA 1)
Chromosome
12q13.13
RefSeq
NG_012296
Characteristics
KRT7-AS is localized to the nucleus and it shares a 213-nucleotide-long region with the seventh exon of KRT7.[1]
Expression
KRT7-AS levels are much lower than KRT7 mRNA levels in the same samples. In MKN28 and KATOIII cells, KRT7-AS is 61 and 41 fold lower than KRT7 mRNA (P<0.01).
Function
KRT7-AS and KRT7 mRNA form a duplex RNA-RNA structure at their overlapping region, which can increase KRT7 mRNA stability and protect KRT7 mRNA from degradation.[1] The overexpressed KRT7-AS in gastric cancer cells leads to increased proliferation and migration.[1]
Disease
gastric cancer [1]
Labs working on this lncRNA
- Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
- Division of Gastroenterology, Departments of Medicine and Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
