Difference between revisions of "KRT7-AS"
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===Expression=== | ===Expression=== | ||
| − | KRT7-AS levels are much lower than KRT7 mRNA levels in the same samples. In MKN28 and KATOIII cells, KRT7 | + | KRT7-AS levels are much lower than KRT7 mRNA levels in the same samples. In MKN28 and KATOIII cells, KRT7-AS is 61 and 41 fold lower than KRT7 mRNA (P<0.01). |
===Function=== | ===Function=== | ||
| − | KRT7-AS and KRT7 mRNA form a duplex RNA-RNA structure at their overlapping region, which can increase KRT7 mRNA | + | KRT7-AS and KRT7 mRNA form a duplex RNA-RNA structure at their overlapping region, which can increase KRT7 mRNA stability and protect KRT7 mRNA from degradation.<ref name="ref1"/> |
The overexpressed KRT7-AS in gastric cancer cells leads to increased proliferation and migration.<ref name="ref1"/> | The overexpressed KRT7-AS in gastric cancer cells leads to increased proliferation and migration.<ref name="ref1"/> | ||
===Disease=== | ===Disease=== | ||
| − | gastric cancer | + | gastric cancer <ref name="ref1"/> |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Latest revision as of 01:33, 16 October 2017
Contents
Annotated Information
Expression pattern of KRT7-AS and KRT7 mRNAs in cell lines and tissues.[1]
Regulatory function of KRT7-AS overexpression to KRT7.[1]
Regulatory function of KRT7 mRNA downregulation to KRT7-AS and the rescue effect of KRT7-AS overexpression in KRT7 mRNA-downregulated cells.[1]
Approved Symbol
KRT7-AS (KRT7 antisense RNA 1)
Chromosome
12q13.13
RefSeq
NG_012296
Characteristics
KRT7-AS is localized to the nucleus and it shares a 213-nucleotide-long region with the seventh exon of KRT7.[1]
Expression
KRT7-AS levels are much lower than KRT7 mRNA levels in the same samples. In MKN28 and KATOIII cells, KRT7-AS is 61 and 41 fold lower than KRT7 mRNA (P<0.01).
Function
KRT7-AS and KRT7 mRNA form a duplex RNA-RNA structure at their overlapping region, which can increase KRT7 mRNA stability and protect KRT7 mRNA from degradation.[1] The overexpressed KRT7-AS in gastric cancer cells leads to increased proliferation and migration.[1]
Disease
gastric cancer [1]
Labs working on this lncRNA
- Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
- Division of Gastroenterology, Departments of Medicine and Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
