Difference between revisions of "LINC01844"
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==Annotated Information== | ==Annotated Information== | ||
| − | [[File:Expression of LOC101926975 in HSCR.png|right|thumb|500px|''' | + | [[File:Expression of LOC101926975 in HSCR.png|right|thumb|500px|'''LINC01844 is significantly downregulated in HSCR tissues compared control samples'''.<ref name="ref1" />]] |
| − | [[File:Function of LOC101926975 in vitro.jpg|right|thumb|400px|'''(A) | + | [[File:Function of LOC101926975 in vitro.jpg|right|thumb|400px|'''(A) LINC01844 was effectively knocked down in SK-N-BE(2) cells. Downregulation of LINC01844 suppressed cell proliferation (B)and caused cell cycle arrest (C)without impact on cell apoptosis (D)or cell migration.'''.<ref name="ref1" />]] |
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | LINC01844 | + | LINC01844 （long intergenic non-protein coding RNA 1844） |
| − | |||
| − | |||
===Synonyms=== | ===Synonyms=== | ||
LOC101926975 | LOC101926975 | ||
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5q31.3 | 5q31.3 | ||
===RefSeq ID=== | ===RefSeq ID=== | ||
| − | |||
| − | |||
NR_110558 | NR_110558 | ||
===Characteristics=== | ===Characteristics=== | ||
| − | + | LINC01844 locates on chromosome 5 (142745600-142760993) and it is near the gene FGF1.<ref name="ref1" /> | |
===Expression=== | ===Expression=== | ||
| − | Compared with the control tissues, the expression of | + | Compared with the control tissues, the expression of LINC01844 is down-regulated in hirschsprung disease (HSCR) tissues.<ref name="ref1" /> |
{| class='wikitable' style="text-align:center" | {| class='wikitable' style="text-align:center" | ||
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===Function=== | ===Function=== | ||
| − | SiRNA experiment | + | SiRNA experiment shows that LINC01844 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition.<ref name="ref1" /> |
| − | The expression correlation analysis shows | + | The expression correlation analysis shows LINC01844 regulate the expression of FGF1.<ref name="ref1" /> |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
* Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing 210008; 2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China. | * Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing 210008; 2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China. | ||
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==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1"> | + | <ref name="ref1"> Shen, Z., et al., Downregulated Expression of Long Non-Coding RNA LOC101926975 Impairs both Cell Proliferation and Cell Cycle and Its Clinical Implication in Hirschsprung Disease Patients. Int J Med Sci, 2016. 13(4): p. 292-7. |
</ref>(1) | </ref>(1) | ||
</references> | </references> | ||
Latest revision as of 02:11, 23 October 2017
Contents
Annotated Information
LINC01844 is significantly downregulated in HSCR tissues compared control samples.[1]
(A) LINC01844 was effectively knocked down in SK-N-BE(2) cells. Downregulation of LINC01844 suppressed cell proliferation (B)and caused cell cycle arrest (C)without impact on cell apoptosis (D)or cell migration..[1]
Approved Symbol
LINC01844 （long intergenic non-protein coding RNA 1844）
Synonyms
LOC101926975
Chromosome
5q31.3
RefSeq ID
NR_110558
Characteristics
LINC01844 locates on chromosome 5 (142745600-142760993) and it is near the gene FGF1.[1]
Expression
Compared with the control tissues, the expression of LINC01844 is down-regulated in hirschsprung disease (HSCR) tissues.[1]
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-AACCCAGTGTTCAAAACCCCA- 3' | 5'-GCAGGGGAAAATACCAGGGAA- 3'[1] |
Function
SiRNA experiment shows that LINC01844 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition.[1] The expression correlation analysis shows LINC01844 regulate the expression of FGF1.[1]
Labs working on this lncRNA
- Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing 210008; 2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
- State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; 3. Key Laboratory of Modern Toxicology (Nanjing Medical University), Ministry of Education, China.
