Difference between revisions of "LNCPRESS1"

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LNCPRESS1:lncRNA p53 regulated and ESC associated 1
 
LNCPRESS1:lncRNA p53 regulated and ESC associated 1
  
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Gene ID: ENSG00000232301
 
===Characteristics===
 
===Characteristics===
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LncPRESS1 is a intergenic transcript annotated by Ensemble as ENSG00000232301, including 756-nt-long multi-exonic.<ref name="ref1" />
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LncPRESS1 is an intergenic transcript <ref name="ref1" />. It is 756 nt in length and is multi-exonic <ref name="ref1" />.
  
 
===Cellular Localization===
 
===Cellular Localization===
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RNA fractionation analysis reveals that lncPRESS1 is primarily localized to nucleus.<ref name="ref1" />
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LncPRESS1 is primarily localized to nucleus <ref name="ref1" />.
  
 
===Function===
 
===Function===
 
[[File:Lncpress1 func.jpg||right|thumb|400px|'''Depletion of LncPRESS1 Affects Pluripotency'''<ref name="ref1" />.]]
 
[[File:Lncpress1 func.jpg||right|thumb|400px|'''Depletion of LncPRESS1 Affects Pluripotency'''<ref name="ref1" />.]]
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Depletion of lncPRESS1 significantly induces expression of lineage-specific genesPAX6,HOXA1, andHOTAIRM1(ectoderm) andFOXA2(ecto/endo-derm), with less or no significant activation of genes associated with endo/mesoderm-specific lineages. In addition, Functional annotation analysis shows that lncPRESS1-activated genes have stem-cell-related functions, whereas genes repressed by lncPRESS1 are collectively represented by functional categories related to cell fate commitment and ectodermdifferentiation. Taken together, LncPRESS1 maintains the pluripotent status of hESCs(human Embryonic stem cells): depletion of lncPRESS1 compromises pluripotency and spontaneous differentiation. <ref name="ref1" />
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LncPRESS1 is a p53-regulated transcript that maintains hESC (human embryonic stem cell) pluripotency in concert with core pluripotency factors <ref name="ref1" />. It safeguards the hESC state by disrupting SIRT6, which maintains high levels of histone H3K56 and H3K9 acetylation at promoters of pluripotency genes <ref name="ref1" />.
  
 
===Regulation===
 
===Regulation===
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Nuclear lncPRESS1 is regulated by p53-dependent alterations in chromatin state during differentiation of hESCs(human Embryonic stem cells).<ref name="ref1" />
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Nuclear lncPRESS1 is regulated by p53-dependent alterations in chromatin state during differentiation of hESCs <ref name="ref1" />.
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===Expression===
 
===Expression===
 
[[File:Lncpress1 expre.JPG||right|thumb|400px|'''Single-Cell Analyses Reveal Lineage-Specific Expression of p53-Regulated LncRNAs'''<ref name="ref1" />.]]
 
[[File:Lncpress1 expre.JPG||right|thumb|400px|'''Single-Cell Analyses Reveal Lineage-Specific Expression of p53-Regulated LncRNAs'''<ref name="ref1" />.]]
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The expression of lncPRESS1 starts as early as the oocyte stage and is sustained to the morulae stage, with much higher expression in hESCs(human Embryonic stem cells). This lncPRESS1 expression pattern suggests that lncPRESS1 is highly enriched in the early stages of human embryonic development. In addition, expression of lncPRESS1 is coordinated with pluripotency-specific genes and repression of lncPRESS1 during differentiation is largely controlled by p53.<ref name="ref1" />  
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The expression of lncPRESS1 starts as early as the oocyte stage and is sustained to the morulae stage, with much higher expression in hESCs, suggesting that lncPRESS1 is highly enriched in the early stages of human embryonic development <ref name="ref1" />. In addition, expression of lncPRESS1 is coordinated with pluripotency-specific genes and repression of lncPRESS1 during differentiation is largely controlled by p53 <ref name="ref1" />.
  
 
===Sequence===
 
===Sequence===

Latest revision as of 09:08, 17 November 2017

Annotated Information

Name

LNCPRESS1:lncRNA p53 regulated and ESC associated 1

Gene ID: ENSG00000232301

Characteristics

LncPRESS1 is an intergenic transcript [1]. It is 756 nt in length and is multi-exonic [1].

Cellular Localization

LncPRESS1 is primarily localized to nucleus [1].

Function

Depletion of LncPRESS1 Affects Pluripotency[1].

LncPRESS1 is a p53-regulated transcript that maintains hESC (human embryonic stem cell) pluripotency in concert with core pluripotency factors [1]. It safeguards the hESC state by disrupting SIRT6, which maintains high levels of histone H3K56 and H3K9 acetylation at promoters of pluripotency genes [1].

Regulation

Nuclear lncPRESS1 is regulated by p53-dependent alterations in chromatin state during differentiation of hESCs [1].

Expression

Single-Cell Analyses Reveal Lineage-Specific Expression of p53-Regulated LncRNAs[1].

The expression of lncPRESS1 starts as early as the oocyte stage and is sustained to the morulae stage, with much higher expression in hESCs, suggesting that lncPRESS1 is highly enriched in the early stages of human embryonic development [1]. In addition, expression of lncPRESS1 is coordinated with pluripotency-specific genes and repression of lncPRESS1 during differentiation is largely controlled by p53 [1].

Sequence

>NR_146480.1 Homo sapiens lncRNA p53 regulated and ESC associated 1 (LNCPRESS1), long non-coding RNA

000001 ACTTGGGACC CCGTTTCCAC CCAGGACCAC AGGCTCAAGA TGGCCTGGTA GATGCAGCCG GCACGCGCCT CTCCTCCGAC 000080
000081 GGGAACAGAA GGAGCCGGTA GGTTTTCACA CTTGCAGCAG ATCCGCTAAG AGAACGAGGG ATTCAGCCGA GAAGCCACTG 000160
000161 GGAGCCCGAG GAGTGGAGCA GAGGCACCCA GGCAGCCTGC GCGGAGAAAT CGGATCGGCT GGGACGGCCT GCAGCCCCCG 000240
000241 CGCGCGGGGA AAGGGAAGAA GTCCTCCCCT ACAAAGCGAA TTCACAAACG GAAGAAGTGA CTGTTCCACA GGATGCGCAG 000320
000321 ATCTCAACGG AAGGACCCAG GAGACATGAA AAAGCAAGGA AATGTGACGC CTTCAGAAGA AACCAGTAAT TCTCCAGCAA 000400
000401 CAGATCCCCA TCCAAAAGAA ATTCAGGAAA GCTCAAACAG AGAATTGAGC AGAGAATTGA CCGGACTGAT TGTAAAGAAG 000480
000481 GTCATCAACA TGGAAGAGTC TTTTGAACAA CAACATAAAG AAATGAGGAA AAGAGGTGGG GAGATATATG AGATGATTAC 000560
000561 CTGCCAGAAA GAGGTTTTAA AATTCAACAG AAGAGTATTT CTGGAACTGA AGAAATCATT GGATGAAATA CAAAGTACAC 000640
000641 TCAAAAGCTT CAATGATAGA CTAGAACAAA TAGAAGAAAA ACTCTCAGGG CATAAAATCT GAAGCATTTT TCTCACTTTA 000720
000721 AAGATTCATG GGTTGTACTC TGGCCATTAA TGTGAACAAA ACCTGCTGGG TTAGTTCTTA TTCTGGGGTC TTGGGTAATC 000800
000801 GTTAGAGCGA AATAAAAATA ATTTCCCTTA GA

Labs working on this lncRNA

  • Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Stem Cell and Development Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Jain AK, Xi Y, McCarthy R, Allton K, Akdemir KC, Patel LR, Aronow B, Lin C, Li W, Yang L, Barton MC. LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56. Mol Cell. 2016 Dec 1;64(5):967-981.
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