Difference between revisions of "COL1A2-AS1"
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===Function=== | ===Function=== | ||
| − | [[ | + | [[File:LncRNA8975-1 fun.jpg|right|thumb|400px|'''Effects of knocking down or overexpressing lncRNA8975-1 on collagen synthesis and α-SMA in HSFs'''<ref name="ref1" />.]] |
| − | Dysregulation of lncRNA8975-1 can affect collagen and α-SMA expression in fibroblasts. Further more, knockdown of lncRNA8975-1 significantly increases cell proliferation, whereas overexpression of lncRNA8975-1 inhibits HSF cell proliferation.<ref name="ref1" /> | + | Dysregulation of lncRNA8975-1 can affect collagen and α-SMA expression in fibroblasts. Further more, knockdown of lncRNA8975-1 significantly increases cell proliferation, whereas overexpression of lncRNA8975-1 inhibits HSF(hypertrophic scar fibroblasts) cell proliferation.<ref name="ref1" /> |
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===Expression=== | ===Expression=== | ||
[[File:LncRNA8975-1 expre.jpg|right|thumb|400px|'''Expression of ''lncRNA8975-1'' in hypertrophic scar tissues and fibroblasts''' <ref name="ref1" />.]] | [[File:LncRNA8975-1 expre.jpg|right|thumb|400px|'''Expression of ''lncRNA8975-1'' in hypertrophic scar tissues and fibroblasts''' <ref name="ref1" />.]] | ||
Latest revision as of 07:23, 25 October 2017
Contents
Annotated Information
Name
COL1A2-AS1:COL1A2 antisense RNA 1
LncRNA8975-1[1]
Characteristics
LncRNA8975-1(TCONS_00013888 in UCSC hg38; also named NONHSAT122029 in NONCODEv4) is an lncRNA located upstream of the COL1A2 gene on chromosome 7(UCSC hg38, chr7:94278999-94392179, ChIPBase named it lncRNA8975-1). In addition, lncRNA8975-1 is a transcript of 352 nucleotides and comprises 5 exons(NONHSAT122029 in NONCODEv4) based on bioinformatics analyses. LncRNA8975-1 contains no overlapping sequence with the transcripts from its neighbouring gene COL1A2 and is a natural antisense lncRNA. [1]
Function
Dysregulation of lncRNA8975-1 can affect collagen and α-SMA expression in fibroblasts. Further more, knockdown of lncRNA8975-1 significantly increases cell proliferation, whereas overexpression of lncRNA8975-1 inhibits HSF(hypertrophic scar fibroblasts) cell proliferation.[1]
Expression
The expression of lncRNA8975-1 is significantly overexpressed in hypertrophic scar tissues compared to normal skin tissues. Furthermore, lncRNA8975-1 expression in hypertrophic scar fibroblasts (HSF) is higher than in normal skin fibroblasts (NSF). [1]
Labs working on this lncRNA
- State key Laboratory of Reproductive Medicine, Department of Plastic&Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China.
