Difference between revisions of "FOXP4-AS1"
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==Annotated Information== | ==Annotated Information== | ||
===Name=== | ===Name=== | ||
| − | + | Approved symbol：FOXP4-AS1:FOXP4 antisense RNA 1 | |
| + | HGNC ID：HGNC:50332 | ||
| + | |||
| + | LncBook transcript ID: HSALNT0106140 | ||
===Characteristics=== | ===Characteristics=== | ||
The FOXP4-AS1 gene is located at the chromosomal locus 6p21.1 and encodes a 588 bp transcript.<ref name="ref1" /> | The FOXP4-AS1 gene is located at the chromosomal locus 6p21.1 and encodes a 588 bp transcript.<ref name="ref1" /> | ||
| − | |||
===Function=== | ===Function=== | ||
| − | + | [[File:Foxp4 func.png||right|thumb|400px|'''Effect of FOXP4-AS1 on CRC cell cycle progression and apoptosis in vitro'''<ref name="ref1" />.]] | |
| − | FOXP4-AS1 overexpression is positively correlated with advanced pathological stages and larger tumour sizes in patients with CRC(colorectal cancer). FOXP4-AS1 knockdown can significantly inhibit cell viability all in five CRC cell lines, increase the percentage of cells in G0/G1 phase and decrease the percentage of cells in S and G2/M phase compared to control cells compared with control cells. as a result, FOXP4-AS1 promotes CRC cell proliferation by promoting cell cycle progression. In addition, FOXP4-AS1 knockdown can also induce CRC cell apoptosis and inhibits CRC cell tumourigenesis in vivo.<ref name="ref1" /> | + | * FOXP4-AS1 overexpression is positively correlated with advanced pathological stages and larger tumour sizes in patients with CRC(colorectal cancer). FOXP4-AS1 knockdown can significantly inhibit cell viability all in five CRC cell lines, increase the percentage of cells in G0/G1 phase and decrease the percentage of cells in S and G2/M phase compared to control cells compared with control cells. as a result, FOXP4-AS1 promotes CRC cell proliferation by promoting cell cycle progression. In addition, FOXP4-AS1 knockdown can also induce CRC cell apoptosis and inhibits CRC cell tumourigenesis in vivo.<ref name="ref1" /> |
| − | + | * Upregulated FOXP4-AS1 promotes the proliferation, migration and cell cycle, but inhibits apoptosis of Osteosarcoma (OS) cells. Furthermore, FOXP4-AS1 participates in the development and progression of OS by downregulating LATS1 via binding to LSD1 and EZH2<ref name="ref2" />. | |
===Expression=== | ===Expression=== | ||
[[File:Foxp4-as1-exp.JPG|right|thumb|400px|'''The expression of Foxp4-as1'''<ref name="ref1" />.]] | [[File:Foxp4-as1-exp.JPG|right|thumb|400px|'''The expression of Foxp4-as1'''<ref name="ref1" />.]] | ||
The expression of FOXP4-AS1 is consistently up-regulated in CRC(colorectal cancer) than in adjacent normal tissues. In addition, BioGPS data set analysis indicates that the FOXP4-AS1 gene is not expressed in normal human colorectal tissues<ref name="ref1" /> | The expression of FOXP4-AS1 is consistently up-regulated in CRC(colorectal cancer) than in adjacent normal tissues. In addition, BioGPS data set analysis indicates that the FOXP4-AS1 gene is not expressed in normal human colorectal tissues<ref name="ref1" /> | ||
| + | |||
| + | FOXP4-AS1 was overexpressed in OS tissues than that of paracancerous tissues<ref name="ref2" />. | ||
===Diseases=== | ===Diseases=== | ||
Colorectal cancer <ref name="ref1" /> | Colorectal cancer <ref name="ref1" /> | ||
| + | |||
| + | Osteosarcoma <ref name="ref2" /> | ||
===Sequence=== | ===Sequence=== | ||
>NR_126415.1 Homo sapiens FOXP4 antisense RNA 1 (FOXP4-AS1), transcript variant 1, long non-coding RNA | >NR_126415.1 Homo sapiens FOXP4 antisense RNA 1 (FOXP4-AS1), transcript variant 1, long non-coding RNA | ||
| Line 33: | Line 39: | ||
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
*The Second Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. | *The Second Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. | ||
| + | *Department of Orthopedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. | ||
==References== | ==References== | ||
<references> | <references> | ||
| Line 39: | Line 46: | ||
FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and | FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and | ||
apoptosis in colorectal cancer. Cell Prolif. 2017 Feb;50(1). | apoptosis in colorectal cancer. Cell Prolif. 2017 Feb;50(1). | ||
| − | </ref> | + | </ref>(1) |
| + | <ref name="ref2"> | ||
| + | Yang L, Ge D, Chen X, Qiu J, Yin Z, Zheng S, Jiang C. Yang L1, Ge D2, Chen X1, Qiu J1, Yin Z1, Zheng S3, Jiang C4. Biochem Biophys Res Commun. 2018 Aug 25;502(4):493-500. | ||
| + | </ref>(2) | ||
</references> | </references> | ||
Latest revision as of 09:06, 8 August 2019
Contents
Annotated Information
Name
Approved symbol：FOXP4-AS1:FOXP4 antisense RNA 1
HGNC ID：HGNC:50332
LncBook transcript ID: HSALNT0106140
Characteristics
The FOXP4-AS1 gene is located at the chromosomal locus 6p21.1 and encodes a 588 bp transcript.[1]
Function
Effect of FOXP4-AS1 on CRC cell cycle progression and apoptosis in vitro[1].
- FOXP4-AS1 overexpression is positively correlated with advanced pathological stages and larger tumour sizes in patients with CRC(colorectal cancer). FOXP4-AS1 knockdown can significantly inhibit cell viability all in five CRC cell lines, increase the percentage of cells in G0/G1 phase and decrease the percentage of cells in S and G2/M phase compared to control cells compared with control cells. as a result, FOXP4-AS1 promotes CRC cell proliferation by promoting cell cycle progression. In addition, FOXP4-AS1 knockdown can also induce CRC cell apoptosis and inhibits CRC cell tumourigenesis in vivo.[1]
- Upregulated FOXP4-AS1 promotes the proliferation, migration and cell cycle, but inhibits apoptosis of Osteosarcoma (OS) cells. Furthermore, FOXP4-AS1 participates in the development and progression of OS by downregulating LATS1 via binding to LSD1 and EZH2[2].
Expression
The expression of Foxp4-as1[1].
The expression of FOXP4-AS1 is consistently up-regulated in CRC(colorectal cancer) than in adjacent normal tissues. In addition, BioGPS data set analysis indicates that the FOXP4-AS1 gene is not expressed in normal human colorectal tissues[1]
FOXP4-AS1 was overexpressed in OS tissues than that of paracancerous tissues[2].
Diseases
Colorectal cancer [1]
Osteosarcoma [2]
Sequence
>NR_126415.1 Homo sapiens FOXP4 antisense RNA 1 (FOXP4-AS1), transcript variant 1, long non-coding RNA
000001 CCCTGGTTTT CTGTGGAAAG TGAGCTTCTG GGTTCGACAG TGGGACCGGC ACAGACCTTC CCGCAGCTAC AGGCCATACG 000080
000081 ACAACCCCGC TGCTCTTTCT TTCTGCGGGC ACTCGGGCCA GTCCTAACAA TTGCCCCTCA AGCTGTGTGT GCTGCCCTAA 000160
000161 CCCTCAATCC CGAACCCGAA ACAGTGCGTG CTGGGACGAA TCTAGGCAGG TCTCCGAAAC CGGGGTGAAG ATGCTGAAGT 000240
000241 TCAGGTCATT CCGGACTCCT GACGCCGCCA GTCCCGCGGT GAGACGTGAG CGCCATTGGC GTCCGTGGCC TCTGTTTCCG 000320
000321 TGGCAACCTA GTAACCATTA ATTTTCAATT AAAGGAGACA AAAAGCTCGA TGACAGCTCC AGGTCTGCTG AAGATGTCAA 000400
000401 GAATCTGTAT TAATATACAG CAAGAGAGCA TAATTGTGTG TCCATCTTCC AGAGCAGCGA AAAATGGAGG GATAATTACC 000480
000481 AGCTCGAAAG CCACTCTGTA ATTTAGTTCT TACTGTCACC ACAGCCCTAC ACATTAGCAT AAATTAAAAG CAGAGTTTAT 000560
000561 TGTTATCAAA GTGCAAAAAA AAAAAAAA
000081 ACAACCCCGC TGCTCTTTCT TTCTGCGGGC ACTCGGGCCA GTCCTAACAA TTGCCCCTCA AGCTGTGTGT GCTGCCCTAA 000160
000161 CCCTCAATCC CGAACCCGAA ACAGTGCGTG CTGGGACGAA TCTAGGCAGG TCTCCGAAAC CGGGGTGAAG ATGCTGAAGT 000240
000241 TCAGGTCATT CCGGACTCCT GACGCCGCCA GTCCCGCGGT GAGACGTGAG CGCCATTGGC GTCCGTGGCC TCTGTTTCCG 000320
000321 TGGCAACCTA GTAACCATTA ATTTTCAATT AAAGGAGACA AAAAGCTCGA TGACAGCTCC AGGTCTGCTG AAGATGTCAA 000400
000401 GAATCTGTAT TAATATACAG CAAGAGAGCA TAATTGTGTG TCCATCTTCC AGAGCAGCGA AAAATGGAGG GATAATTACC 000480
000481 AGCTCGAAAG CCACTCTGTA ATTTAGTTCT TACTGTCACC ACAGCCCTAC ACATTAGCAT AAATTAAAAG CAGAGTTTAT 000560
000561 TGTTATCAAA GTGCAAAAAA AAAAAAAA
Labs working on this lncRNA
- The Second Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.
- Department of Orthopedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Li J, Lian Y, Yan C, Cai Z, Ding J, Ma Z, Peng P, Wang K. Long non-coding RNA FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and apoptosis in colorectal cancer. Cell Prolif. 2017 Feb;50(1).
- ↑ 2.0 2.1 2.2 Yang L, Ge D, Chen X, Qiu J, Yin Z, Zheng S, Jiang C. Yang L1, Ge D2, Chen X1, Qiu J1, Yin Z1, Zheng S3, Jiang C4. Biochem Biophys Res Commun. 2018 Aug 25;502(4):493-500.
