Difference between revisions of "GAS1RR"
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GAS1RR | GAS1RR | ||
===Function=== | ===Function=== | ||
| − | [[ | + | [[File:LncRNA Hh fun.jpg|right|thumb|400px|'''lncRNA‐Hh promotes mammosphere enrichment in breast cancer cells'''<ref name="ref1" />.]] |
LncRNA‐Hh Maintains Mammosphere Enrichment in Breast Cancer Cells In Vitro. In addition, lncRNA‐Hh can promote Breast Cancer Tumorigenesis In Vivo.<ref name="ref1" /> | LncRNA‐Hh Maintains Mammosphere Enrichment in Breast Cancer Cells In Vitro. In addition, lncRNA‐Hh can promote Breast Cancer Tumorigenesis In Vivo.<ref name="ref1" /> | ||
| + | |||
===Expression=== | ===Expression=== | ||
| − | [[ | + | [[File:LncRNA Hh exp.jpg|right|thumb|400px|'''LncRNA‐Hh levels are correlated with endogenous expression of Twist in breast cancer cells''' <ref name="ref1" />.]] |
The expression of lncRNA‐Hh is remarkably upregulated in MCF‐7/Twist mammospheres. In line with this finding, the level of lncRNA‐Hh is found to be higher in Twist‐positive parental Hs578T and BT549 mammosphere cells than that in Twist‐negative parental MCF‐7 mammosphere cells. In addition, knockdown of Twist in MCF‐7/Twist, Hs578T, and BT549 by shRNAs decreased the lncRNA‐Hh expression in their mammosphere cells, which is comparable to that in MCF‐7/Vector mammosphere cells.<ref name="ref1" /> | The expression of lncRNA‐Hh is remarkably upregulated in MCF‐7/Twist mammospheres. In line with this finding, the level of lncRNA‐Hh is found to be higher in Twist‐positive parental Hs578T and BT549 mammosphere cells than that in Twist‐negative parental MCF‐7 mammosphere cells. In addition, knockdown of Twist in MCF‐7/Twist, Hs578T, and BT549 by shRNAs decreased the lncRNA‐Hh expression in their mammosphere cells, which is comparable to that in MCF‐7/Vector mammosphere cells.<ref name="ref1" /> | ||
| + | |||
===Diseases=== | ===Diseases=== | ||
Breast Cancer<ref name="ref1" /> | Breast Cancer<ref name="ref1" /> | ||
Latest revision as of 07:01, 14 January 2018
Contents
Annotated Information
Name
LncRNA-Hh:a Hedgehog signaling pathway‐associated lncRNA[1]
GAS1RR
Function
lncRNA‐Hh promotes mammosphere enrichment in breast cancer cells[1].
LncRNA‐Hh Maintains Mammosphere Enrichment in Breast Cancer Cells In Vitro. In addition, lncRNA‐Hh can promote Breast Cancer Tumorigenesis In Vivo.[1]
Expression
LncRNA‐Hh levels are correlated with endogenous expression of Twist in breast cancer cells [1].
The expression of lncRNA‐Hh is remarkably upregulated in MCF‐7/Twist mammospheres. In line with this finding, the level of lncRNA‐Hh is found to be higher in Twist‐positive parental Hs578T and BT549 mammosphere cells than that in Twist‐negative parental MCF‐7 mammosphere cells. In addition, knockdown of Twist in MCF‐7/Twist, Hs578T, and BT549 by shRNAs decreased the lncRNA‐Hh expression in their mammosphere cells, which is comparable to that in MCF‐7/Vector mammosphere cells.[1]
Diseases
Breast Cancer[1]
Sequence
>gi|388596722|ref|NR_049794.1| Homo sapiens GAS1 adjacent regulatory RNA (GAS1RR), long non-coding RNA
000001 CTATCAACTC CATCTGTCAC AAAAATTAAG GCTAAATCTC CTCTCCAGAA GCAGAGGGAG CCGGGGCTCC GACGCGCTCA 000080
000081 GCGTCGGGCT GTCTGCCTCT CCCTAGAGGC CAAGTGAATT TGAAATGGCA AAAGTCACAG CCGGAGGCCC AGCACTAGGA 000160
000161 GATTCCTCCG GCTGCGGGAA ATCTTCCTGT ACCTGCTGAA GCTGCTGCGT TCCTCAGAGG CGCTTGGTCT GCCGTGGGAA 000240
000241 GCTGCACCTC TGCAGTCCCC AAAACCAAAA TCAAACCTTA AAAGAGCCAG ACTGAGAAGC CAGTCACCAC GTAAGACATC 000320
000321 TGGACCACCT TCAGACTCGC ATGCTGTGAG GAAGCCCATG CTTACTATGT GTAGAGGATA CATGGAGAAG GAAAGAGATG 000400
000401 CCTGGCCAGC TCCCTGCTGT TTCAGCCATG CAGAGGTGCT GAGCAGCTAA TTGGAGGGGA TAGTATGAGC CTCCAAAGAT 000480
000481 TAGGGAAGAA AATTGCAGTT GAAGAAAACT TGCTTTGGTT CAATGCAAAA ATAATGGGAT GAATGGCATG CTGAAATATC 000560
000561 ATATGACTTA CGAAAATGAT GAATGGTTTA TTGAATCTAC ATATGTGGAA CCCATGAATG GGAGTCGGAG AAGGGGGCAA 000640
000641 CTGTATACGC AAAAAGCTAT CATAATTGCC AAAATAGTGA TAACAATGTT GAAACACTAC TGGGATTACT ACTGTTAATG 000720
000721 ACTACCAGTG ATCAAGCACC TCCCCTGCCC CAGTGTTTGC CTGCCTTGTT TGAAGACACG AAAAAATGTA CACAAAATGA 000800
000801 TTTAGAACTG TTGAACTTTT CAGAAAATAA TTTAAAATCA TCTACCTCAT AACTAAAGGA CACTGAATTG GAGCCAGCTG 000880
000881 ATGTAAGGAG CTTACCTTGG TTGCCACCTT CTGGTCTCTG TTTGAGGAAC AACTGCATGT GATTAAGGAT GAAGAAACTG 000960
000961 AGACCCCAAG AATTTAAGTA ATTTGTTCAA GGCAACACAC TGCTATGTGG TAGAACTACA AATTGAGCCC AAATAATCCA 001040
001041 GCTTCAGATA CTATGCAAAG GTATCCTAGG TGTGGGGGTG ATAACCTGGT GACAATCCCT TCTCAGAAGG AAAACAGGTC 001120
001121 CCATCTACAG AGGTGAAGCA GAGTGTGGAA CTGAAAAACT CAATGGAAGA ATGGCTATTA AGATTTAGGA CGGCTGGGAA 001200
001201 ATAATAAAGT AATAATAATA ATACTAGGTA TTGACGTGTG CTACATGCCA GGCCTTGGGT GACATTTGGA TTGATTCCCA 001280
001281 TTTTCTTTAC TTTTCAGCAG TGGGGTCTTT CACCTTTCAA GCTCTGCCTG AGAAGTCAAC ATGGTGGCAT TTGGCTAGGT 001360
001361 TCTTTTAGGC AACCAATTGT TTTAACATGA TTTGTTGAAA AGCCTATTCT CTCTTTCATT GAACTATAAT GCTAGCTCTG 001440
001441 TCATAAATCA AATTTTCATT TGATTTATGA TATGAAAATT ATATGCATTT GATTGATATG CATTTTTTCT CCAATGATAC 001520
001521 TCAACTGTCT TAATTATATA ATTTTGTAGT AATTCTTGGT ATCTAATTAG GCAAATACCC ACTCCCAACC CTGTTTCTTT 001600
001601 TGTTTTTAAA TCCAGGGGTG TTTTGGATAT TCTCGTTCAT TTGTGCTTCC ACCTACATTT TTCAGTTAAC TTGTCAGGTA 001680
001681 CGAAAAAATA AAAGGCAAAA TTTTTTATCC TTAAATCAAT TTGGGCAAGT TTGCAGTTTT TTCTTGTATT GTAACTTCCA 001760
001761 ATCTATGAAT ATGATCTATT TTTTCACCAA TTTATGGCTT CTTCCAATAA CATTTTATAA TTGTCTTTTT AGAGGCCTTA 001840
001841 TCTTTTGTTT AGATTCATAT CTAGGTATTT AATATTTTTG ATGCTGTTAT AAATGGTATT TTTAAAAATA TATACATTTT 001920
001921 TAACTATTTC ACATAGAAAA CTTTAATGGA TTTTTAAAAT GTAGATTTGT ATTCAGTAAA CCTGTTAAAA TCTCTTAGAA 002000
002001 TGTCTAAGAG TTTATTTATT CAATTTGATT TTCTTTTTTT TTTTTTCTCC TGGAGACGGA GTTTCGCTCT TGTTGCCCAG 002080
002081 GCTGGAGTGC AGTGGCATGA TCTCAGCTCA CTGCAACCTC CGGCTCCCGG GTTCAAGCAA TTCTCCTGTC TCAGCCTCCT 002160
002161 GAGTAGCTGG GATTACAGGC TCCCACCACC ATGCCCAGCT AATTTTTGGT ATTTTTAGTA GAGACAGAGT TTCACCATGT 002240
002241 TGGCCAGGCT GGTCTCAAAC TCCTGACCTC AGGTGATCCG ACTGCTTTGG CTTCCCAAAC TGCTGGCATT ACAGGCGTGA 002320
002321 GCCACTGCGC CCTGGCCTAT TCTACTGGAT TTTCTATGCA ATTGTGTTAT AACTCATCAT AAAGATAATT TTATTTCTTT 002400
002401 TCCACAATCT TTACAGGTTT AATTTTTTTC TATGCCTTGC TGCACTCTCT ATGATTTCCA GTATTGGCAC TACTCTGGCC 002480
002481 TTTGGTCTTT GCTCTTGCAT CAGCCTTTCA TAATTGGGTA TGTTTGTTGT AAGTTTTCTG TAGAGAGTCT TTATGAGGTT 002560
002561 AAGAGATTTG TTTCATTTCT AGTTTATTAA GAGATTTTAT TATAGATCAA TGTTAAATTT TATCAAAATT TCTCCATTGC 002640
002641 ATTTCTATTG AGATGATCAC ATGATTATTA AAAATTAGTA TAAAGATTTA TTATTTTGAT ATTTTAAAAT CAGGTTTATT 002720
002721 GAGGCATAAT TTATATATAA TAAAATTTAC CCTATTAGAG TATCCAGTCC AGTAAGTTTT GGTAAATGTA TGCGAATAAC 002800
002801 ACAATAAACA GGTTTAGAAC TTTTCCATCA CCACAAAAAG TTTATCAGGC CCCTTTGCAG TTAATACTCA CCTTCTCTCC 002880
002881 AGCCCCAGTA AACCATGGAT CTGCTTTTTG TTACTGTAGT TTTTCCTTTA CTTTGATTTT TTTGAGTGTT AAGCCAGCCT 002960
002961 TACATTTCTG AGTTAACTTG GTCATGATAT CTTCTACAAA CATTAATGAA TTTAGTATGA TTGGCTGATG CCTTTGCTTT 003040
003041 CCTATACTGT CCTTGCCTGG TTGGTACAAG GATTATATAA TACTTATAAA GTGAGTTGAA GACAGTTTCC TCTTTTCACC 003120
003121 AGCTGGAATA ATTTATGTAT TATTGAAATT AATTGCTCCT TAAATACTTG GCAGAATTCA CTACAAAGGC ACTTAATTCT 003200
003201 AGACCTTTTG GAGGAAGATA AAATACTGAT TTTTTAAATC ATTATTTTAT TTTTGTAATA CAGCTTATTT TTCCAGAAAC 003280
003281 TTCTACTTTT CGTTTACATC TTCAAGTCAG ATTAAAGTTG TATTAATAAC CCCTTATTAT TTAAATCTCA GCAGAATGTG 003360
003361 AAGTTATGTT CCCCCTTTGT ATCCATTTTT TTCTCTAGAT ATTTTTCTGT TACCTGTTTT AAATTTAATT CCATTGTGGT 003440
003441 CAGAGATAAT ACTTTGTATG ACTTGCATTC TTTTATGTAT ATTGAGACTT GTTATAAGGC ACAGAGTATG GTTTATCTTG 003520
003521 GTAATCATTC GTGGCACACT TAAAAATCAT GTGTTTTCTG CTATTGTTGA GTGGGATGTT CTGTAACTGT GAATTAGGTC 003600
003601 AAGTTAGTTG ACAGTGTTGT TCAAGTCTTT TATATTATTA CTGACTTTCT TTCTACTCAC TCTATCAATT AGTGAAAGGT 003680
003681 GTCAATATTT CCAGTTATAA TCATGGATTT GTCTATTATT ACTTTCAGTT AGAAATTTCT AGCTGAAATT ATCTATTTCT 003760
003761 ACTTTCAGTT AGTGTTAGCT TGCTATATCT TTTTTCCATC CTTCTTCTTT TAACCCAATG TATCTTTATA TTGACATTAC 003840
003841 ATATATGATT TATATTATAT TATGTTACTA TATCTTGTAT GCAGCATATA TTTGGATCTT TTTTATCCAA TCTGATGATC 003920
003921 TTTGCTTTTT AATTAATGTA TTTAGATCAT TTACATTTAC TGTGATTATT AATATGTATT AAGTTCAAAT CTACCACTTT 004000
004001 GGTATTGAAT ATCTAATTGT CCCATTTGTT CTTTGTTTCA AAAAAACTCT TTTTTTGCCT TTTTTTATAT CAAGTATTTT 004080
004081 AAAATTCTAT TTCATCTTCT TTGTTTGCTT ATTAGCTATA ACTTTATTTT GCTAATTTAG TGGTTGCTTT AGGGTTTATA 004160
004161 GTAAACATCT TCAACTTATC ACATTCTATG TTCTAGTCAT ATTATATTAT TTAACACATA GTATAAAAAC TTTATTGTAG 004240
004241 TATACTTTCA TTTTCCTCCA GTAATTGTGC GATTCTTGTC ATCTATTTTG CTTCTACATG TTATAAACTC TACATGATTT 004320
004321 TGTAATATTT TTGTTTAAAC AATATTTATT TAGACTTAAT AATAAATAAT AAAAATATAT GCTAACCA
000081 GCGTCGGGCT GTCTGCCTCT CCCTAGAGGC CAAGTGAATT TGAAATGGCA AAAGTCACAG CCGGAGGCCC AGCACTAGGA 000160
000161 GATTCCTCCG GCTGCGGGAA ATCTTCCTGT ACCTGCTGAA GCTGCTGCGT TCCTCAGAGG CGCTTGGTCT GCCGTGGGAA 000240
000241 GCTGCACCTC TGCAGTCCCC AAAACCAAAA TCAAACCTTA AAAGAGCCAG ACTGAGAAGC CAGTCACCAC GTAAGACATC 000320
000321 TGGACCACCT TCAGACTCGC ATGCTGTGAG GAAGCCCATG CTTACTATGT GTAGAGGATA CATGGAGAAG GAAAGAGATG 000400
000401 CCTGGCCAGC TCCCTGCTGT TTCAGCCATG CAGAGGTGCT GAGCAGCTAA TTGGAGGGGA TAGTATGAGC CTCCAAAGAT 000480
000481 TAGGGAAGAA AATTGCAGTT GAAGAAAACT TGCTTTGGTT CAATGCAAAA ATAATGGGAT GAATGGCATG CTGAAATATC 000560
000561 ATATGACTTA CGAAAATGAT GAATGGTTTA TTGAATCTAC ATATGTGGAA CCCATGAATG GGAGTCGGAG AAGGGGGCAA 000640
000641 CTGTATACGC AAAAAGCTAT CATAATTGCC AAAATAGTGA TAACAATGTT GAAACACTAC TGGGATTACT ACTGTTAATG 000720
000721 ACTACCAGTG ATCAAGCACC TCCCCTGCCC CAGTGTTTGC CTGCCTTGTT TGAAGACACG AAAAAATGTA CACAAAATGA 000800
000801 TTTAGAACTG TTGAACTTTT CAGAAAATAA TTTAAAATCA TCTACCTCAT AACTAAAGGA CACTGAATTG GAGCCAGCTG 000880
000881 ATGTAAGGAG CTTACCTTGG TTGCCACCTT CTGGTCTCTG TTTGAGGAAC AACTGCATGT GATTAAGGAT GAAGAAACTG 000960
000961 AGACCCCAAG AATTTAAGTA ATTTGTTCAA GGCAACACAC TGCTATGTGG TAGAACTACA AATTGAGCCC AAATAATCCA 001040
001041 GCTTCAGATA CTATGCAAAG GTATCCTAGG TGTGGGGGTG ATAACCTGGT GACAATCCCT TCTCAGAAGG AAAACAGGTC 001120
001121 CCATCTACAG AGGTGAAGCA GAGTGTGGAA CTGAAAAACT CAATGGAAGA ATGGCTATTA AGATTTAGGA CGGCTGGGAA 001200
001201 ATAATAAAGT AATAATAATA ATACTAGGTA TTGACGTGTG CTACATGCCA GGCCTTGGGT GACATTTGGA TTGATTCCCA 001280
001281 TTTTCTTTAC TTTTCAGCAG TGGGGTCTTT CACCTTTCAA GCTCTGCCTG AGAAGTCAAC ATGGTGGCAT TTGGCTAGGT 001360
001361 TCTTTTAGGC AACCAATTGT TTTAACATGA TTTGTTGAAA AGCCTATTCT CTCTTTCATT GAACTATAAT GCTAGCTCTG 001440
001441 TCATAAATCA AATTTTCATT TGATTTATGA TATGAAAATT ATATGCATTT GATTGATATG CATTTTTTCT CCAATGATAC 001520
001521 TCAACTGTCT TAATTATATA ATTTTGTAGT AATTCTTGGT ATCTAATTAG GCAAATACCC ACTCCCAACC CTGTTTCTTT 001600
001601 TGTTTTTAAA TCCAGGGGTG TTTTGGATAT TCTCGTTCAT TTGTGCTTCC ACCTACATTT TTCAGTTAAC TTGTCAGGTA 001680
001681 CGAAAAAATA AAAGGCAAAA TTTTTTATCC TTAAATCAAT TTGGGCAAGT TTGCAGTTTT TTCTTGTATT GTAACTTCCA 001760
001761 ATCTATGAAT ATGATCTATT TTTTCACCAA TTTATGGCTT CTTCCAATAA CATTTTATAA TTGTCTTTTT AGAGGCCTTA 001840
001841 TCTTTTGTTT AGATTCATAT CTAGGTATTT AATATTTTTG ATGCTGTTAT AAATGGTATT TTTAAAAATA TATACATTTT 001920
001921 TAACTATTTC ACATAGAAAA CTTTAATGGA TTTTTAAAAT GTAGATTTGT ATTCAGTAAA CCTGTTAAAA TCTCTTAGAA 002000
002001 TGTCTAAGAG TTTATTTATT CAATTTGATT TTCTTTTTTT TTTTTTCTCC TGGAGACGGA GTTTCGCTCT TGTTGCCCAG 002080
002081 GCTGGAGTGC AGTGGCATGA TCTCAGCTCA CTGCAACCTC CGGCTCCCGG GTTCAAGCAA TTCTCCTGTC TCAGCCTCCT 002160
002161 GAGTAGCTGG GATTACAGGC TCCCACCACC ATGCCCAGCT AATTTTTGGT ATTTTTAGTA GAGACAGAGT TTCACCATGT 002240
002241 TGGCCAGGCT GGTCTCAAAC TCCTGACCTC AGGTGATCCG ACTGCTTTGG CTTCCCAAAC TGCTGGCATT ACAGGCGTGA 002320
002321 GCCACTGCGC CCTGGCCTAT TCTACTGGAT TTTCTATGCA ATTGTGTTAT AACTCATCAT AAAGATAATT TTATTTCTTT 002400
002401 TCCACAATCT TTACAGGTTT AATTTTTTTC TATGCCTTGC TGCACTCTCT ATGATTTCCA GTATTGGCAC TACTCTGGCC 002480
002481 TTTGGTCTTT GCTCTTGCAT CAGCCTTTCA TAATTGGGTA TGTTTGTTGT AAGTTTTCTG TAGAGAGTCT TTATGAGGTT 002560
002561 AAGAGATTTG TTTCATTTCT AGTTTATTAA GAGATTTTAT TATAGATCAA TGTTAAATTT TATCAAAATT TCTCCATTGC 002640
002641 ATTTCTATTG AGATGATCAC ATGATTATTA AAAATTAGTA TAAAGATTTA TTATTTTGAT ATTTTAAAAT CAGGTTTATT 002720
002721 GAGGCATAAT TTATATATAA TAAAATTTAC CCTATTAGAG TATCCAGTCC AGTAAGTTTT GGTAAATGTA TGCGAATAAC 002800
002801 ACAATAAACA GGTTTAGAAC TTTTCCATCA CCACAAAAAG TTTATCAGGC CCCTTTGCAG TTAATACTCA CCTTCTCTCC 002880
002881 AGCCCCAGTA AACCATGGAT CTGCTTTTTG TTACTGTAGT TTTTCCTTTA CTTTGATTTT TTTGAGTGTT AAGCCAGCCT 002960
002961 TACATTTCTG AGTTAACTTG GTCATGATAT CTTCTACAAA CATTAATGAA TTTAGTATGA TTGGCTGATG CCTTTGCTTT 003040
003041 CCTATACTGT CCTTGCCTGG TTGGTACAAG GATTATATAA TACTTATAAA GTGAGTTGAA GACAGTTTCC TCTTTTCACC 003120
003121 AGCTGGAATA ATTTATGTAT TATTGAAATT AATTGCTCCT TAAATACTTG GCAGAATTCA CTACAAAGGC ACTTAATTCT 003200
003201 AGACCTTTTG GAGGAAGATA AAATACTGAT TTTTTAAATC ATTATTTTAT TTTTGTAATA CAGCTTATTT TTCCAGAAAC 003280
003281 TTCTACTTTT CGTTTACATC TTCAAGTCAG ATTAAAGTTG TATTAATAAC CCCTTATTAT TTAAATCTCA GCAGAATGTG 003360
003361 AAGTTATGTT CCCCCTTTGT ATCCATTTTT TTCTCTAGAT ATTTTTCTGT TACCTGTTTT AAATTTAATT CCATTGTGGT 003440
003441 CAGAGATAAT ACTTTGTATG ACTTGCATTC TTTTATGTAT ATTGAGACTT GTTATAAGGC ACAGAGTATG GTTTATCTTG 003520
003521 GTAATCATTC GTGGCACACT TAAAAATCAT GTGTTTTCTG CTATTGTTGA GTGGGATGTT CTGTAACTGT GAATTAGGTC 003600
003601 AAGTTAGTTG ACAGTGTTGT TCAAGTCTTT TATATTATTA CTGACTTTCT TTCTACTCAC TCTATCAATT AGTGAAAGGT 003680
003681 GTCAATATTT CCAGTTATAA TCATGGATTT GTCTATTATT ACTTTCAGTT AGAAATTTCT AGCTGAAATT ATCTATTTCT 003760
003761 ACTTTCAGTT AGTGTTAGCT TGCTATATCT TTTTTCCATC CTTCTTCTTT TAACCCAATG TATCTTTATA TTGACATTAC 003840
003841 ATATATGATT TATATTATAT TATGTTACTA TATCTTGTAT GCAGCATATA TTTGGATCTT TTTTATCCAA TCTGATGATC 003920
003921 TTTGCTTTTT AATTAATGTA TTTAGATCAT TTACATTTAC TGTGATTATT AATATGTATT AAGTTCAAAT CTACCACTTT 004000
004001 GGTATTGAAT ATCTAATTGT CCCATTTGTT CTTTGTTTCA AAAAAACTCT TTTTTTGCCT TTTTTTATAT CAAGTATTTT 004080
004081 AAAATTCTAT TTCATCTTCT TTGTTTGCTT ATTAGCTATA ACTTTATTTT GCTAATTTAG TGGTTGCTTT AGGGTTTATA 004160
004161 GTAAACATCT TCAACTTATC ACATTCTATG TTCTAGTCAT ATTATATTAT TTAACACATA GTATAAAAAC TTTATTGTAG 004240
004241 TATACTTTCA TTTTCCTCCA GTAATTGTGC GATTCTTGTC ATCTATTTTG CTTCTACATG TTATAAACTC TACATGATTT 004320
004321 TGTAATATTT TTGTTTAAAC AATATTTATT TAGACTTAAT AATAAATAAT AAAAATATAT GCTAACCA
Labs working on this lncRNA
- Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
