Difference between revisions of "AA174084"
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===Functions=== | ===Functions=== | ||
lncRNA-''AA174084'' is a tumor-suppressor gene which was suggested to play a tumor-suppressor role in Gastric Cancer (GC) tumorigenesis (including tumor initiation, progression, metastasis and prognosis) and proposed as a potential biomarker for screening EGC. <ref name="ref2" /> | lncRNA-''AA174084'' is a tumor-suppressor gene which was suggested to play a tumor-suppressor role in Gastric Cancer (GC) tumorigenesis (including tumor initiation, progression, metastasis and prognosis) and proposed as a potential biomarker for screening EGC. <ref name="ref2" /> | ||
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Function Mechanism: tumor suppression | Function Mechanism: tumor suppression | ||
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Description: biomarker | Description: biomarker | ||
| − | === | + | ===Expression=== |
| − | ''AA174084'' | + | [[File:AA174084.jpg|right|thumb|400px|'''AA174084 average expression level in adjacent normal tissues was 3.18 times the average level in GC tissues'''<ref name="ref2" />]] |
| + | Expression levels of AA174084 were down‐regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues (P < .001). <ref name="ref2" /> | ||
===Disease=== | ===Disease=== | ||
Disease: gastric cancer <ref name="ref2" /> | Disease: gastric cancer <ref name="ref2" /> | ||
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Dysfunction type: expression | Dysfunction type: expression | ||
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<ref name="ref1"> Virgilio E, Giarnieri E, Giovagnoli MR, Montagnini M, Proietti A, D’Urso R et al. Long non-coding RNAs in the gastric juice of gastric cancer patients[J]. Pathology - Research and Practice. 2018, 214(9):1239-1246.</ref>(1) | <ref name="ref1"> Virgilio E, Giarnieri E, Giovagnoli MR, Montagnini M, Proietti A, D’Urso R et al. Long non-coding RNAs in the gastric juice of gastric cancer patients[J]. Pathology - Research and Practice. 2018, 214(9):1239-1246.</ref>(1) | ||
<ref name="ref2"> Shao Y, Ye M, Jiang X, Sun W, Ding X, Liu Z et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer[J]. Cancer. 2014, 120(21):3320-3328.</ref>(2) | <ref name="ref2"> Shao Y, Ye M, Jiang X, Sun W, Ding X, Liu Z et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer[J]. Cancer. 2014, 120(21):3320-3328.</ref>(2) | ||
| + | </references> | ||
Latest revision as of 07:51, 23 November 2018
AA174084 long noncoding RNA potentially may play a role during Gastric Cancer development
Contents
Annotated Information
Name
AA174084 (also known simply as AA) is a gastric juice long noncoding RNA [1]
Alias
NA
Functions
lncRNA-AA174084 is a tumor-suppressor gene which was suggested to play a tumor-suppressor role in Gastric Cancer (GC) tumorigenesis (including tumor initiation, progression, metastasis and prognosis) and proposed as a potential biomarker for screening EGC. [2]
Function Mechanism: tumor suppression
Biological Process: pathogenic process
Description: biomarker
Expression
Expression levels of AA174084 were down‐regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues (P < .001). [2]
Disease
Disease: gastric cancer [2]
Dysfunction type: expression
Description: AA174084 may have potential as marker for the early diagnosis of GC
Labs Working
Department of Biochemistry and Molecular Biology, and Zhejiang Provincial Key Laboratory of Pathophysiology,Ningbo University, China
References
- ↑ Virgilio E, Giarnieri E, Giovagnoli MR, Montagnini M, Proietti A, D’Urso R et al. Long non-coding RNAs in the gastric juice of gastric cancer patients[J]. Pathology - Research and Practice. 2018, 214(9):1239-1246.
- ↑ 2.0 2.1 2.2 2.3 Shao Y, Ye M, Jiang X, Sun W, Ding X, Liu Z et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer[J]. Cancer. 2014, 120(21):3320-3328.
