Difference between revisions of "CDRT3"

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(Created page with "==Annotated Information== ===Name=== Approved symbol: CDRT3 Approved name: CMT1A duplicated region transcript 3 HGNC ID: HGNC:14382 RefSeq ID: NR_146601 ===Characteristics...")
 
(→‎References)
 
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===Characteristics ===
 
===Characteristics ===
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[[File:Schematic representation of the LeXis gene locus on Integrative Genome Viewer (IGV) showing histone marks from LICR ENCODE data.jpg|right|thumb|Schematic representation of the LeXis gene locus([https://www.ncbi.nlm.nih.gov/pubmed/27251289 (Sallam T 2016)])]]
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Please input evolution information here.
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LeXis, named as "Liver-expressed LXR-induced sequence", it's gene locus Lie in close proximity to the canonical LXR target gene Abca1 in mouse([https://www.ncbi.nlm.nih.gov/pubmed/27251289 (Sallam T 2016)]), was distinct gene with Abca1, almost exclusively located in the insoluble nuclear pellet in fractionation studies, along with the known nuclear lncRNAs XIST and histone H3.
 
  
 
===Expression===
 
===Expression===
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The highly expressed in primary mouse hepatocytes treated with GW3965([http://www.ncbi.nlm.nih.gov/pubmed/27251289 (Sallam T 2016)]) and upregulated in OS(Osteosarcoma) tissues([http://www.ncbi.nlm.nih.gov/pubmed/28744406 (Wang G 2017)]).
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CDRT3 reveal no expression in adult tissues but obvious expression in fetal tissues.([http://www.ncbi.nlm.nih.gov/pubmed/11381029 (Inoue K 2001)])
  
 
===Regulation===
 
===Regulation===
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===Function===
 
===Function===
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[[File:LeXis functions as a ceRNA of β-catenin.jpg|right|thumb|LeXis functions as a ceRNA of β-catenin([https://www.ncbi.nlm.nih.gov/pubmed/28744406 (Wang G 2017)])]]
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Please input evolution information here.
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LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism([https://www.ncbi.nlm.nih.gov/pubmed/27251289 (Sallam T 2016)]).
 
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LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth([https://www.ncbi.nlm.nih.gov/pubmed/28744406 (Wang G 2017)]).
 
  
 
===Disease===
 
===Disease===
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* osteosarcoma
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* colon adenocarcinoma <ref name="ref1" />
 
  
 
===Evolution===
 
===Evolution===
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==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
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* No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
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* Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
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* Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.
 
  
 
==References==
 
==References==
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<references>
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<ref name="ref1"> Shahriyari L. Effect of normalization methods on the performance of supervised
 
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learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a
 
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predictor of survival in patients with colon adenocarcinoma. Brief Bioinform.
 
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2017 Nov 3. doi: 10.1093/bib/bbx153.
 
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</ref>(1)
 
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</references>
 
 
[http://www.lncrnadb.org/7SK/ Annotation originally sourced from lncRNAdb].
 
[http://www.lncrnadb.org/7SK/ Annotation originally sourced from lncRNAdb].
  
  
 
[[Category:Intergenic]][[Category:NONHSAG043942]][[Category:Transcripts]]
 
[[Category:Intergenic]][[Category:NONHSAG043942]][[Category:Transcripts]]

Latest revision as of 03:18, 28 July 2019

Annotated Information

Name

Approved symbol: CDRT3

Approved name: CMT1A duplicated region transcript 3

HGNC ID: HGNC:14382

RefSeq ID: NR_146601

Characteristics

Please input evolution information here.

Expression

CDRT3 reveal no expression in adult tissues but obvious expression in fetal tissues.((Inoue K 2001))

Regulation

Please input evolution information here.

Function

Please input evolution information here.

Disease

Please input evolution information here.

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

References

Annotation originally sourced from lncRNAdb.

Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=CDRT3&oldid=1275997"