Difference between revisions of "LINC00460"
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===Function=== | ===Function=== | ||
| − | * Loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased | + | * Loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression. LINC00460 promotes MMP-9 expression through targeting miR-539, acting as an oncogenic RNA in the meningioma malignancy and accelerating the proliferation and metastasis of meningeoma<ref name="ref2" />. |
| − | the proteins (MMP-2, MMP-9, ZEB1) expression. LINC00460 promotes MMP-9 expression through targeting miR-539, acting as an oncogenic RNA in the meningioma malignancy and accelerating the proliferation and metastasis of meningeoma<ref name="ref2" />. | + | |
===Regulation=== | ===Regulation=== | ||
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===pubmed IDs=== | ===pubmed IDs=== | ||
27591862, 29906745 | 27591862, 29906745 | ||
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===Sequence=== | ===Sequence=== | ||
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GTATTTCCTACTTTATGATCAGGATTAATAAATGTAATTTATTAATCAGAAATTAGTAATTTCTGATTAT | GTATTTCCTACTTTATGATCAGGATTAATAAATGTAATTTATTAATCAGAAATTAGTAATTTCTGATTAT | ||
TAA</dnaseq> | TAA</dnaseq> | ||
| + | |||
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| + | ==Labs working on this lncRNA== | ||
| + | * Qingdao University, Qingdao, Shandong, 266003, China. | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Wang R, Du L, Yang X, Jiang X, Duan W, Yan S, Xie Y, Zhu Y, Wang Q, Wang L, Yang Y, Wang C. Identification of long noncoding RNAs as potential novel diagnosis and prognosis biomarkers in colorectal cancer. J Cancer Res Clin Oncol. 2016 Nov;142(11):2291-301. | ||
| + | </ref>(1) | ||
| + | <ref name="ref2"> | ||
| + | Xing, H., Wang, S., Li, Q., Ma, Y., & Sun, P. Long noncoding RNA LINC00460 targets miR-539/MMP-9 to promote meningioma progression and metastasis. Biomed Pharmacother. 2018 Sep;105:677-682. | ||
| + | </ref>(2) | ||
| + | </references> | ||
Latest revision as of 07:58, 13 August 2019
Contents
Annotated Information
Name
Approved Symbol: LINC00460
Approved Name: long intergenic non-protein coding RNA 460
RefSeq ID: NR_034119
LncBook transcript ID: HSALNT0289038
EnsemblID: ENSG00000233532
Chromosome
13q33.2
Characteristics
-
Function
- Loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression. LINC00460 promotes MMP-9 expression through targeting miR-539, acting as an oncogenic RNA in the meningioma malignancy and accelerating the proliferation and metastasis of meningeoma[1].
Regulation
-
Diseases
Colorectal cancer[2].
Meningeoma[1].
Expression
LncRNA LINC00460 was over-expressed in meningeoma tissue and cells[1].
LINC00460 expression level was significantly up-regulated in meningeoma tissues and malignant meningioma cell lines (IOMM-Lee, CH157-MN)[1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| Quantitative real-time PCR | 5'-AATGGTGGTAGGAGGGAGGA- 3' | 5'-CAAGGGGAATGAACACGAGG- 3'[1] |
Evolution
-
pubmed IDs
27591862, 29906745
Sequence
>NR_034119.2 Homo sapiens long intergenic non-protein coding RNA 460 (LINC00460), transcript variant 1, long non-coding RNA
000001 CTTCCTGCAG AAATCCTCCA GCCCTGTTAG AAATGCCTCA GCCAGGGGGA CTCATCTCCT CAAACCTGGG GGACCGAGAC 000080
000081 CTATGAGAGG TCACAGCATG AGCCAGGACA TCGGAGGTAC CCAGACATTG TTATGAAACT CCGCATGTGC CCCTGGTGGA 000160
000161 CGCTGCTGGA CCCAGCATGC ACACTTCTCG GCTAAGAGTC ACCCTGGATG AACCACCATT GCCAGCGGGG AGCATGTTGC 000240
000241 AGCTTTCCCA CGCAGTGGAT GAGAACGAAG GTTACGACCA TTGTGTGGGA GGCGTCTGTG TAGCAATTGC TGGAATCACT 000320
000321 TGTGGCATTG TAGAAAGACT GAGCGTGGGA AAGAAGACGC ATTCTGAAGT CACCCCGATT TATGTTAAAT TATCACCTTG 000400
000401 ACTACTGCTA TAGAACGAAT GTTTATGTCC CCCACCCAAA TTCGTATGCT AAGACCTAAT AGCCAATAAG ATAGTATTAA 000480
000481 TAGATGGGGC CTTTGGGAGG TGAGTGGCTC ATGAGGGCAG AGTCCTCAAA ACCAGATAAG TGCCCGAATA AAAGGGGCCC 000560
000561 CAGAGAGATC CCTTGCACCG TCTACCATGT GAAGTGTAGA ACACAGCGAG AAGGCCACCT ATGAGCCAGA ACGTGGGCCC 000640
000641 TCACCAGAAC CCAGTTGTGC TGGCACCCTG ATCCTGGACT TCCAGCCTCC AAAATGACGA CAAAGAAGTT TGTTTTTCCT 000720
000721 GAGCCATCCA CTTCAAAGTA TTCTGTCATA GCTCCCCAAA TAGACTAAGA CATCTACTTA ACCTTGGTCA AACGTTTAAC 000800
000801 CTTGGAGTCC ACGCCTCTGA AATGGTGACA ATAACACTGT GTATTTCCTA CTTTATGATC AGGATTAATA AATGTAATTT 000880
000881 ATTAATCAGA AATTAGTAAT TTCTGATTAT TAA
000081 CTATGAGAGG TCACAGCATG AGCCAGGACA TCGGAGGTAC CCAGACATTG TTATGAAACT CCGCATGTGC CCCTGGTGGA 000160
000161 CGCTGCTGGA CCCAGCATGC ACACTTCTCG GCTAAGAGTC ACCCTGGATG AACCACCATT GCCAGCGGGG AGCATGTTGC 000240
000241 AGCTTTCCCA CGCAGTGGAT GAGAACGAAG GTTACGACCA TTGTGTGGGA GGCGTCTGTG TAGCAATTGC TGGAATCACT 000320
000321 TGTGGCATTG TAGAAAGACT GAGCGTGGGA AAGAAGACGC ATTCTGAAGT CACCCCGATT TATGTTAAAT TATCACCTTG 000400
000401 ACTACTGCTA TAGAACGAAT GTTTATGTCC CCCACCCAAA TTCGTATGCT AAGACCTAAT AGCCAATAAG ATAGTATTAA 000480
000481 TAGATGGGGC CTTTGGGAGG TGAGTGGCTC ATGAGGGCAG AGTCCTCAAA ACCAGATAAG TGCCCGAATA AAAGGGGCCC 000560
000561 CAGAGAGATC CCTTGCACCG TCTACCATGT GAAGTGTAGA ACACAGCGAG AAGGCCACCT ATGAGCCAGA ACGTGGGCCC 000640
000641 TCACCAGAAC CCAGTTGTGC TGGCACCCTG ATCCTGGACT TCCAGCCTCC AAAATGACGA CAAAGAAGTT TGTTTTTCCT 000720
000721 GAGCCATCCA CTTCAAAGTA TTCTGTCATA GCTCCCCAAA TAGACTAAGA CATCTACTTA ACCTTGGTCA AACGTTTAAC 000800
000801 CTTGGAGTCC ACGCCTCTGA AATGGTGACA ATAACACTGT GTATTTCCTA CTTTATGATC AGGATTAATA AATGTAATTT 000880
000881 ATTAATCAGA AATTAGTAAT TTCTGATTAT TAA
Labs working on this lncRNA
- Qingdao University, Qingdao, Shandong, 266003, China.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Xing, H., Wang, S., Li, Q., Ma, Y., & Sun, P. Long noncoding RNA LINC00460 targets miR-539/MMP-9 to promote meningioma progression and metastasis. Biomed Pharmacother. 2018 Sep;105:677-682.
- ↑ Wang R, Du L, Yang X, Jiang X, Duan W, Yan S, Xie Y, Zhu Y, Wang Q, Wang L, Yang Y, Wang C. Identification of long noncoding RNAs as potential novel diagnosis and prognosis biomarkers in colorectal cancer. J Cancer Res Clin Oncol. 2016 Nov;142(11):2291-301.
