Difference between revisions of "SNHG14"

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===Expression===
 
===Expression===
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More distal part of UBE3A-ATS, which overlaps UBE3A, is brain specific<ref name="ref1" />.
  
 
===Regulation===
 
===Regulation===
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In the 7SK ribonucleoprotein, Larp7 binds directly to 3′ terminus of 7SK RNA ([https://www.ncbi.nlm.nih.gov/pubmed/18281698 (Krueger 2008)]) ([https://www.ncbi.nlm.nih.gov/pubmed/18483487 (Markert 2008)]), and prevents degradation of 7SK in vivo ([https://www.ncbi.nlm.nih.gov/pubmed/18281698 (Krueger 2008)]).
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Please input information here.
  
 
===Function===
 
===Function===
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[[File:Model of hLarp7 recognition of the 7SK.png|right|thumb|Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP([https://www.ncbi.nlm.nih.gov/pubmed/29946027 (Eichhorn 2018)])]]
 
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The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse<ref name="ref1" />.
 
The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse<ref name="ref1" />.
  

Latest revision as of 11:21, 11 August 2019

Annotated Information

Name

Approved symbol: SNHG14

Approved name: small nucleolar RNA host gene 14

HGNC ID: HGNC:37462

Previous names: UBE3A antisense RNA 1 (non-protein coding); small nucleolar RNA host gene 14 (non-protein coding)

Previous symbols: UBE3A-AS1

Alias symbols: NCRNA00214; UBE3A-AS; UBE3A-ATS

Alias names: non-protein coding RNA 214; UBE3A antisense

RefSeq ID: NR_146177

LncBook ID: HSALNT0217643

Characteristics

Human UBE3A-ATS is a large (∼460 kb) transcript that initiates in the PWS-IC and extends distally through SNURF/SNRPN, IPW and overlaps UBE3A, alternatively spliced and serves as a host for several types of small nucleolar RNA (snoRNA) of the box C/D class that are contained within the introns and are expressed upon processing of the paternal copy of the host transcript[1].

Expression

More distal part of UBE3A-ATS, which overlaps UBE3A, is brain specific[1].

Regulation

Please input information here.

Function

The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse[1].

Disease

Angelman syndrome (AS)[1]

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

References

  1. ↑ 1.0 1.1 1.2 1.3 Landers M, Bancescu DL, Le Meur E, et al. Regulation of the large (approximately 1000 kb) imprinted murine Ube3a antisense transcript by alternative exons upstream of Snurf/Snrpn[J]. Nucleic Acids Res, 2004, 32: 3480-3492.

Annotation originally sourced from lncRNAdb.

Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=SNHG14&oldid=1276263"