Difference between revisions of "LINC00319"

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===Characteristics ===
 
===Characteristics ===
−
[[File:Functional domains of 7SK RNA..png|right|thumb|Functional domains of 7SK RNA([https://www.ncbi.nlm.nih.gov/pubmed/19246988 (Diribarne 2009)])]]
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[[File:Relative LINC00319 expression in lung adenocarcinoma tissues and its clinical significance.jpg|right|thumb|Relative LINC00319 expression in lung adenocarcinoma tissues and its clinical significance]]
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Long intergenic non-protein coding RNA 319 (LINC00319) (NR_152722), is located on chromosome 21q22.3 and has a transcript length of 2901 nucleotides<ref name="ref2" />.
  
 
===Expression===
 
===Expression===
−
LINC00319 is up-regulated in human primary lung adenocarcinoma tissues<ref name="ref1" />.
+
LINC00319 was significantly up-regulated in lung adenocarcinoma tissues compared with normal lung tissues<ref name="ref2" />.
 +
 
 +
Reported to be highly expressed in lung cancer<ref name="ref1" />.
  
 
===Regulation===
 
===Regulation===
 +
Please input regulartion information here.
  
 
===Function===
 
===Function===
−
[[File:Model of hLarp7 recognition of the 7SK.png|right|thumb|Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP([https://www.ncbi.nlm.nih.gov/pubmed/29946027 (Eichhorn 2018)])]]
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[[File:LINC00319 is a direct target of miR-450b-5p.jpg|right|thumb|LINC00319 is a direct target of miR-450b-5p]]
  
 
Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.<ref name="ref1" />
 
Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.<ref name="ref1" />
 +
 +
LINC00319 was also shown to regulate the miR-450b-5p targeted gene enhancer of zeste homolog 2 (EZH2) by functioning as a competitive endogenous RNA (ceRNA) for miR-450b-5p in lung adenocarcinoma, thereby inhibiting the expression of EZH2 and promoting lung adenocarcinoma cell proliferation.<ref name="ref2" />.
  
 
===Disease===
 
===Disease===
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<ref name="ref2">Zhang ZW, Chen JJ, Xia SH, et al. Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2[J]. Gene, 2018, 650: 60-67.</ref>(2)
 
<ref name="ref2">Zhang ZW, Chen JJ, Xia SH, et al. Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2[J]. Gene, 2018, 650: 60-67.</ref>(2)
 
</references>
 
</references>
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 +
===Sequence===
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>NR_152722.1 Homo sapiens long intergenic non-protein coding RNA 319 (LINC00319), long non-coding RNA
 +
<dnaseq>GTTTAGATTAGGTTGGAAGTCACCTGGGCTGAGCTGATGGCTGATTCCGTCAGCAAAAAGAACTGTGGAA
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CATACTGGCACTTGGGCCGGTGTGAAGCCACCCCCCTGCCATGAAAAATGGCTCTTCCCTGCCACAGCCG
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GCCCAGCGGGAGCCAGGTCAGGGCCTGGAGACACAGCGCCCCCCACCGGAGCCACTGCCCGGCCCAGCAG
 +
CACCTGCGGAGAATCCCACCAGCTCCCACGCCTCCCGCCGCGCCACCGCCCCGGCTTTCTGCAAATCCAC
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CTTATGGAAGCCGGATAAGCACCTCCTCCTCTGATGCGTCACAGTCACAGGTCCTGGTGAGGAGGGAGCC
 +
ACGCCAAGCACAGCGGCTGGAACAGGGGCAAGTGGGTGCCCACCCCGAAGTGCAGGCAATGAACTTGTGC
 +
TGTAGCCCATGGTGAGCTGTGGGGCTGTTTGTGACTGCAGCGTAGCCAAGCCCATCCCGCCTGATGCGGC
 +
CTCTTCATCCAGAGTGGGGGTGACGTGCCAGCCCCCACCTCACCGGAATGCTGGGAGGAGCGTCTCCACG
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GAAGGAGCTCACTTTGTCAGCTGTAATGTGCTGTGACTATCGTAAAGTTCCTTCCGGGTGCAGAGTGATA
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CATGAACCCTGGGGACTCACTCCAACTTGGTATTGATTTTCTCCACGGAGGACCCAGCAGTCACGGCCCG
 +
TGTCTGCACAGCCCCTTGGATCCTGCGGAGGAATTCAGCCGGCCCCTCCCCCTGTGCCGAAAACCACGGA
 +
GGCAAAGCCAGGCCAGGGTACAGTGAGAACACGGGAGAGGACTGAGAGACCGCTGGCTGCCGAGGGAGGA
 +
AGAGCAGGATTCGCACCCCCGTCATCGCTGGGCCCACACGCCGCCGACAGCTTCCGCGTGTGGCCATCTG
 +
TCTTTCAGAAACCCTCTGGCAGAGGGACCCAGCAGATGACACGGGGGCCGTTCACACTCTGAAACCTGCC
 +
TGGAGTCAAAACACTGCTGGCGAGCCTCCACCGCAAACCCAATCCAGATGGTCTTCCCTGGTGGCCCTCG
 +
GGGTGGCGGGCACCCTGCCCACTCCCTGCCAGCCCCTGCCCGCTGGACTCCAGGCCCGGCCGAGCCCCCG
 +
ACCGGTCTCCTGACCCAGCATGCTGCTCTCCCCTGGGCCCGGCTTTCTCGCCCGCTGGGACTCCCAGGCC
 +
CCTCCAGCCCAGCCCCGAGAGCAGGAGCCCCAAGGGAGGCTTGGCGGCTGTGGAGGCGAGTGGGCCACGT
 +
GTAGCTGGGAGGCCGGCAGGACCAGGAGCCCCTCACAGCGCAGCACCCACAGCATCACGAGCCACTTCCA
 +
CTCCTGGGTGGCCTGGGGGCCCCCACCCTGCTCTGAGCTGCCCCTTGTTGTGACCTGGGGTCCCCCGTGG
 +
TGGGCCCGCCCCTTGAGCCTGGGATCCAGCCTCAGCGAGGCTCCAGAAGTGTCGTCTCCGCCGGCCAGGC
 +
GTCAGCGCCTCCACCCAGGATCACACACTCCTATCTCTGCACTTCTGCCCTCCATCCTGCTCCACGCCGC
 +
CTCTGCTTGTTATTCCAGCACATTCCAGGGTGATGCCTGCTGAAGCCACGCAGCCAGTGCCTCCACCCTA
 +
CCCCCCATCTGACCCACCGGCCCCTTCCGCACGCTGGAAGCCTGCCCGGCCTGAAGTGTCCTCACCTGTC
 +
GCCCTATCCTCCCCTCCACTCCAGCCCACCGGTGACTCAGCCCTCACAGCTCTCTCCTCCCCGAGGGAGC
 +
CGGTGACTTGGCTCTGATGGTGCCGGGACCCAGCCCCGGCATGTTCAGAATCCTTGTCCTTTAACCTGCG
 +
TCCACATGTAGTCGCCTCCACCTCCCTGCCTGAACCTCCAGGCCCTGCAGAGCAAACACTGCTGCCTGCA
 +
GGAGACCCCTGGGGCCTTCTCCGTCCCCTCATCCTCCTAAGGAGCCTCCCCTGCCACCGTGCCAGAATGT
 +
GCCGGAGGAACAGAGGCCCGAGCCTCCCGTGGCCCCAGCGAGGCTTCCTCTGGGGAAGACAGTGAGCCCA
 +
ACGCCCTGGCTCTCGAGGGGTGGACGGAGTCCAGCTGGCATCGACCGGGTGCCCCTCTTCACCGGTGTCC
 +
ACAGTCCTTGAGAGCAAAGGGTTCCCAGAGGCGACCTCCCTCCTGCACAGGCATTTGTCATCCTTACCCT
 +
CTAGGACAGCTTTGCCATGTGCAGTGAACCCCTGGACAGTGTTGCGTGCCACTTTGCCGGATTTGGACTG
 +
TATACAGACCGAAGCATGTGGCATGAAGCCTTCTGCTGTCAGCAAGTTCCTTGTCCCTCGACAGTATGTG
 +
CCCAGGCTGCCCTTCAAGGTGGCAGTGATGGCAGTTGTCTCTTGCACGCTGCGTACAGTTCTGTCACTGA
 +
CTCTTACACACAGCCCTGGAGACGGGAGAGTGCCGGGAGCATTCTATGCAAGTGTCCTGGCCTTTGCGGG
 +
CGTCTCCACAGCACAAACACGAGTCAGGGACCACCCCTCTTCTGCTTCCATGATTCCACCAACTGGGTGG
 +
GGCAGAGCAGTGCCAGGGCCGGAGGCACGCCCCAGGTGAGGGCAGGTGGCCATGCCAGTGAGTGCACTGC
 +
GTTCTCAGTTAATTCATCCGAAATATTTCTAAGTTTCTTGATTATTGCAGTTGCATCCCCAAGATAATGC
 +
CGCCCTCACCAAGTAGAAGGCACATGTGCTCTGATGGCCCCTCCCACACTGGGGTCAGGGCACAGCAACT
 +
TAGCGAGGCGACGTGGGGGCTCAGAGGACCTCGGACCAGGCTCGGCACATGGGGCTTCTCCAGCCAGCCA
 +
GGGGGAAGCACCCTGCAGACTGCTAACTTTTGCAAAATAGAGTAAAAAAGATCAGCTAGAAAAATAAAAC
 +
AAAAAAGGAAAGATATACAAAATACAAGGCC</dnaseq>

Latest revision as of 05:42, 12 August 2019

Annotation

Name

Approved symbol: LINC00319

Approved name: long intergenic non-protein coding RNA 319

HGNC ID: HGNC:19730

Previous symbols: C21orf125; NCRNA00319

Previous names: chromosome 21 open reading frame 125; non-protein coding RNA 319

Alias symbols: PRED49; FLJ38036

RefSeq ID: NR_026960

LncBook ID: HSALNT0289323

Characteristics

Relative LINC00319 expression in lung adenocarcinoma tissues and its clinical significance

Long intergenic non-protein coding RNA 319 (LINC00319) (NR_152722), is located on chromosome 21q22.3 and has a transcript length of 2901 nucleotides[1].

Expression

LINC00319 was significantly up-regulated in lung adenocarcinoma tissues compared with normal lung tissues[1].

Reported to be highly expressed in lung cancer[2].

Regulation

Please input regulartion information here.

Function

LINC00319 is a direct target of miR-450b-5p

Linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.[2]

LINC00319 was also shown to regulate the miR-450b-5p targeted gene enhancer of zeste homolog 2 (EZH2) by functioning as a competitive endogenous RNA (ceRNA) for miR-450b-5p in lung adenocarcinoma, thereby inhibiting the expression of EZH2 and promoting lung adenocarcinoma cell proliferation.[1].

Disease

lung cancer [2]

lung adenocarcinoma carcinogenesis [1]

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.[2]
  • Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Zhang ZW, Chen JJ, Xia SH, et al. Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2[J]. Gene, 2018, 650: 60-67.
  2. ↑ 2.0 2.1 2.2 2.3 Zhou B, Yuan W and Li X. Long Intergenic Noncoding RNA 319 (linc00319) Promotes Cell Proliferation and Invasion in Lung Cancer Cells by Directly Downregulating the Tumor Suppressor MiR-32[J]. Oncol Res, 2017.

Sequence

>NR_152722.1 Homo sapiens long intergenic non-protein coding RNA 319 (LINC00319), long non-coding RNA

000001 GTTTAGATTA GGTTGGAAGT CACCTGGGCT GAGCTGATGG CTGATTCCGT CAGCAAAAAG AACTGTGGAA CATACTGGCA 000080
000081 CTTGGGCCGG TGTGAAGCCA CCCCCCTGCC ATGAAAAATG GCTCTTCCCT GCCACAGCCG GCCCAGCGGG AGCCAGGTCA 000160
000161 GGGCCTGGAG ACACAGCGCC CCCCACCGGA GCCACTGCCC GGCCCAGCAG CACCTGCGGA GAATCCCACC AGCTCCCACG 000240
000241 CCTCCCGCCG CGCCACCGCC CCGGCTTTCT GCAAATCCAC CTTATGGAAG CCGGATAAGC ACCTCCTCCT CTGATGCGTC 000320
000321 ACAGTCACAG GTCCTGGTGA GGAGGGAGCC ACGCCAAGCA CAGCGGCTGG AACAGGGGCA AGTGGGTGCC CACCCCGAAG 000400
000401 TGCAGGCAAT GAACTTGTGC TGTAGCCCAT GGTGAGCTGT GGGGCTGTTT GTGACTGCAG CGTAGCCAAG CCCATCCCGC 000480
000481 CTGATGCGGC CTCTTCATCC AGAGTGGGGG TGACGTGCCA GCCCCCACCT CACCGGAATG CTGGGAGGAG CGTCTCCACG 000560
000561 GAAGGAGCTC ACTTTGTCAG CTGTAATGTG CTGTGACTAT CGTAAAGTTC CTTCCGGGTG CAGAGTGATA CATGAACCCT 000640
000641 GGGGACTCAC TCCAACTTGG TATTGATTTT CTCCACGGAG GACCCAGCAG TCACGGCCCG TGTCTGCACA GCCCCTTGGA 000720
000721 TCCTGCGGAG GAATTCAGCC GGCCCCTCCC CCTGTGCCGA AAACCACGGA GGCAAAGCCA GGCCAGGGTA CAGTGAGAAC 000800
000801 ACGGGAGAGG ACTGAGAGAC CGCTGGCTGC CGAGGGAGGA AGAGCAGGAT TCGCACCCCC GTCATCGCTG GGCCCACACG 000880
000881 CCGCCGACAG CTTCCGCGTG TGGCCATCTG TCTTTCAGAA ACCCTCTGGC AGAGGGACCC AGCAGATGAC ACGGGGGCCG 000960
000961 TTCACACTCT GAAACCTGCC TGGAGTCAAA ACACTGCTGG CGAGCCTCCA CCGCAAACCC AATCCAGATG GTCTTCCCTG 001040
001041 GTGGCCCTCG GGGTGGCGGG CACCCTGCCC ACTCCCTGCC AGCCCCTGCC CGCTGGACTC CAGGCCCGGC CGAGCCCCCG 001120
001121 ACCGGTCTCC TGACCCAGCA TGCTGCTCTC CCCTGGGCCC GGCTTTCTCG CCCGCTGGGA CTCCCAGGCC CCTCCAGCCC 001200
001201 AGCCCCGAGA GCAGGAGCCC CAAGGGAGGC TTGGCGGCTG TGGAGGCGAG TGGGCCACGT GTAGCTGGGA GGCCGGCAGG 001280
001281 ACCAGGAGCC CCTCACAGCG CAGCACCCAC AGCATCACGA GCCACTTCCA CTCCTGGGTG GCCTGGGGGC CCCCACCCTG 001360
001361 CTCTGAGCTG CCCCTTGTTG TGACCTGGGG TCCCCCGTGG TGGGCCCGCC CCTTGAGCCT GGGATCCAGC CTCAGCGAGG 001440
001441 CTCCAGAAGT GTCGTCTCCG CCGGCCAGGC GTCAGCGCCT CCACCCAGGA TCACACACTC CTATCTCTGC ACTTCTGCCC 001520
001521 TCCATCCTGC TCCACGCCGC