Difference between revisions of "EVA1A-AS"

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Approved name:EVA1A antisense RNA
 
Approved name:EVA1A antisense RNA
  
HGNC ID:HGNC:55283
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HGNC ID:55283
  
 
Alias symbol:EVA1A-AS1
 
Alias symbol:EVA1A-AS1
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Please input information here.
 
Please input information here.
 
===Function===
 
===Function===
Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor<ref name="ref" />.
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Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor<ref name="ref1" />.
  
EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression<ref name="ref" />.  
+
EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression<ref name="ref1" />.  
 
===Regulation===
 
===Regulation===
 
Depletion of EVA1A-AS suppressed cell proliferation of HepG2 cells by upregulation of EVA1A. Overexpression of EVA1A caused cell death at the G2/M phase via microtubule catastrophe.<ref name="ref1" />.
 
Depletion of EVA1A-AS suppressed cell proliferation of HepG2 cells by upregulation of EVA1A. Overexpression of EVA1A caused cell death at the G2/M phase via microtubule catastrophe.<ref name="ref1" />.
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==References==
 
==References==
 
<references>
 
<references>
<ref name="ref1">Niehus SE, Allister AB, Hoffmann A, Wiehlmann L, Tamura T, Tran DDH. Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner. Sci Rep. 2019 Nov 21;9(1):17319. doi: 10.1038/s41598-019-53944-2. PMID: 31754186;</ref>
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<ref name="ref1">Niehus SE, Allister AB, Hoffmann A, Wiehlmann L, Tamura T, Tran DDH. Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner. Sci Rep. 2019 Nov 21;9(1):17319. doi: 10.1038/s41598-019-53944-2. PMID: 31754186;</ref>(1)
 
</references>
 
</references>

Latest revision as of 10:53, 19 February 2021

Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor.

Annotated Information

Name

Approved symbol:EVA1A-AS

Approved name:EVA1A antisense RNA

HGNC ID:55283

Alias symbol:EVA1A-AS1

RefSeq ID:NR_110281

Characteristics

Please input information here.

Function

Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor[1].

EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression[1].

Regulation

Depletion of EVA1A-AS suppressed cell proliferation of HepG2 cells by upregulation of EVA1A. Overexpression of EVA1A caused cell death at the G2/M phase via microtubule catastrophe.[1].

Expression

suppressed EVA1A expression levels are negatively correlated with differentiation grade in 365 primary HCCs, while EVA1A-AS expression levels are positively correlated with patient survival.[1].

Diseases

  • Hepatocellular carcinoma.[1].

Labs working on this lncRNA

  • Institut fuer Biochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623, Hannover, Germany.[1]
  • Klinik für Orthopädie OE8893, Medizinische Hochschule Hannover, Stadtfelddamm 34, D-30625, Hannover, Germany.[1]
  • Zentrale Forschungseinrichtung Genomics OE 9415, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623, Hannover, Germany.[1]
  • Institut fuer Biochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623, Hannover, Germany. Tran.Doan@MH-Hannover.de.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Niehus SE, Allister AB, Hoffmann A, Wiehlmann L, Tamura T, Tran DDH. Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner. Sci Rep. 2019 Nov 21;9(1):17319. doi: 10.1038/s41598-019-53944-2. PMID: 31754186;