Difference between revisions of "PXN-AS1"
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| − | PXN-AS1 | + | LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.<ref name="ref1" /> |
==Annotated Information== | ==Annotated Information== | ||
===Name=== | ===Name=== | ||
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Approved name:PXN antisense RNA 1 | Approved name:PXN antisense RNA 1 | ||
| − | HGNC ID | + | HGNC ID:44123 |
Previous name:PXN antisense RNA 1 (non-protein coding) | Previous name:PXN antisense RNA 1 (non-protein coding) | ||
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LncBook ID:HSALNG0094500 | LncBook ID:HSALNG0094500 | ||
===Characteristics=== | ===Characteristics=== | ||
| − | PXN-AS1 | + | PXN-AS1 is upregulated in NPC tissues and cell lines.<ref name="ref1" /> |
===Function=== | ===Function=== | ||
| − | PXN-AS1 | + | PXN-AS1 interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.<ref name="ref1" /> |
| − | === | + | ===Expression=== |
| − | PXN-AS1- | + | [[File: PXN-AS1-exp.png|thumb|550px|Overexpression of PXN‐AS1 promotes nasopharyngeal carcinoma cell proliferation, migration, and invasion.<ref name="ref1"/>]] |
| − | === | + | PXN-AS1 overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1 silencing suppresses NPC cell proliferation, migration, and invasion in vitro.<ref name="ref1" /> |
| − | LncRNA PXN-AS1 | + | |
| + | ===Regulation=== | ||
| + | LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.<ref name="ref1" /> | ||
===Diseases=== | ===Diseases=== | ||
Nasopharyngeal carcinoma (NPC) malignancy<ref name="ref1" /> | Nasopharyngeal carcinoma (NPC) malignancy<ref name="ref1" /> | ||
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*Department of Otolaryngology, Henan Province People's Hospital of Henan University, Zhengzhou, China.<ref name="ref1" /> | *Department of Otolaryngology, Henan Province People's Hospital of Henan University, Zhengzhou, China.<ref name="ref1" /> | ||
*Department of Radiotherapy, Henan Province People's Hospital of Henan University, Zhengzhou, China.<ref name="ref1" /> | *Department of Radiotherapy, Henan Province People's Hospital of Henan University, Zhengzhou, China.<ref name="ref1" /> | ||
| − | ==References== | + | ==References== |
| + | <references> | ||
<ref name="ref1">Jia X, Niu P, Xie C, Liu H. Long noncoding RNA PXN-AS1-L promotes the malignancy of nasopharyngeal carcinoma cells via upregulation of SAPCD2. Cancer Med. 2019 Aug;8(9):4278-4291. doi: 10.1002/cam4.2227. Epub 2019 Jun 7. </ref>(1) | <ref name="ref1">Jia X, Niu P, Xie C, Liu H. Long noncoding RNA PXN-AS1-L promotes the malignancy of nasopharyngeal carcinoma cells via upregulation of SAPCD2. Cancer Med. 2019 Aug;8(9):4278-4291. doi: 10.1002/cam4.2227. Epub 2019 Jun 7. </ref>(1) | ||
</references> | </references> | ||
Latest revision as of 04:22, 22 February 2021
LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]
Contents
Annotated Information
Name
Approved symbol:PXN-AS1
Approved name:PXN antisense RNA 1
HGNC ID:44123
Previous name:PXN antisense RNA 1 (non-protein coding)
Alias symbol:EyeLinc4
RefSeq ID:NR_038924
LncBook ID:HSALNG0094500
Characteristics
PXN-AS1 is upregulated in NPC tissues and cell lines.[1]
Function
PXN-AS1 interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.[1]
Expression
Overexpression of PXN‐AS1 promotes nasopharyngeal carcinoma cell proliferation, migration, and invasion.[1]
PXN-AS1 overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1 silencing suppresses NPC cell proliferation, migration, and invasion in vitro.[1]
Regulation
LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]
Diseases
Nasopharyngeal carcinoma (NPC) malignancy[1]
Labs working on this lncRNA
- Department of Otolaryngology, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]
- Department of Radiotherapy, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]
