Difference between revisions of "PRANCR"
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===Characteristics=== | ===Characteristics=== | ||
PRANCR regions reside in non-protein-coding regions of the genome.<ref name="ref1" /> | PRANCR regions reside in non-protein-coding regions of the genome.<ref name="ref1" /> | ||
| − | ===Function=== | + | ===Function=== |
| − | PRANCR regulates keratinocyte proliferation, cell cycle progression, and clonogenicity.<ref name="ref1" /> | + | [[File: PRANCR-fun.jpeg|thumb|550px|PRANCR is a novel epidermal lncRNA and is essential for keratinocyte proliferation and cell cycle progression.<ref name="ref1"/>]] |
| + | PRANCR regulates keratinocyte proliferation, cell cycle progression, and clonogenicity.<ref name="ref1" /> | ||
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===Regulation=== | ===Regulation=== | ||
PRANCR controls the expression of 1136 genes, with strong enrichment for late cell cycle genes containing a CHR promoter element.PRANCR depletion led to increased levels of both total and nuclear CDKN1A (also known as p21).<ref name="ref1" /> | PRANCR controls the expression of 1136 genes, with strong enrichment for late cell cycle genes containing a CHR promoter element.PRANCR depletion led to increased levels of both total and nuclear CDKN1A (also known as p21).<ref name="ref1" /> | ||
Latest revision as of 04:06, 22 February 2021
PRANCR is a novel lncRNA regulating epidermal homeostasis and identify other lncRNA candidates that may have roles in this process as well.[1]
Contents
Annotated Information
Name
Approved symbol：PRANCR
Approved name：progenitor renewal associated non-coding RNA
HGNC ID:51126
Previous name：long intergenic non-protein coding RNA 1481|CNOT2 divergent transcript
RefSeq ID：NR_120460
Prev_symbol：LINC01481|CNOT2-DT
Characteristics
PRANCR regions reside in non-protein-coding regions of the genome.[1]
Function
PRANCR regulates keratinocyte proliferation, cell cycle progression, and clonogenicity.[1]
Regulation
PRANCR controls the expression of 1136 genes, with strong enrichment for late cell cycle genes containing a CHR promoter element.PRANCR depletion led to increased levels of both total and nuclear CDKN1A (also known as p21).[1]
Expression
PRANCR-deficient epidermis displayed impaired stratification with reduced expression of differentiation genes that are altered in human skin diseases, including keratins 1 and 10, filaggrin, and loricrin.[1]
Diseases
Human skin diseases[1]
Labs working on this lncRNA
- Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Department of Oncology of the First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.[1]
- Department of Dermatology, University of California-San Diego, La Jolla, California 92109, USA.[1]
- CAS Center for Excellence in Molecular Cell Sciences, University of Science and Technology of China, Hefei, 230027, China.[1]
References
[1](1)
</references>- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Cai P, Otten ABC, Cheng B, Ishii MA, Zhang W, Huang B, Qu K, Sun BK. A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis. Genome Res. 2020 Jan;30(1):22-34. doi: 10.1101/gr.251561.119. Epub 2019 Dec 4.
