Difference between revisions of "EVA1A-AS"
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===Function=== | ===Function=== | ||
| − | Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor<ref name=" | + | Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor<ref name="ref1" />. |
| − | EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression<ref name=" | + | EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression<ref name="ref1" />. |
===Regulation=== | ===Regulation=== | ||
Depletion of EVA1A-AS suppressed cell proliferation of HepG2 cells by upregulation of EVA1A. Overexpression of EVA1A caused cell death at the G2/M phase via microtubule catastrophe.<ref name="ref1" />. | Depletion of EVA1A-AS suppressed cell proliferation of HepG2 cells by upregulation of EVA1A. Overexpression of EVA1A caused cell death at the G2/M phase via microtubule catastrophe.<ref name="ref1" />. | ||
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==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1">Niehus SE, Allister AB, Hoffmann A, Wiehlmann L, Tamura T, Tran DDH. Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner. Sci Rep. 2019 Nov 21;9(1):17319. doi: 10.1038/s41598-019-53944-2. PMID: 31754186;</ | + | <ref name="ref1">Niehus SE, Allister AB, Hoffmann A, Wiehlmann L, Tamura T, Tran DDH. Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner. Sci Rep. 2019 Nov 21;9(1):17319. doi: 10.1038/s41598-019-53944-2. PMID: 31754186;</ref>(1) |
</references> | </references> | ||
Latest revision as of 10:53, 19 February 2021
Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor.
Contents
Annotated Information
Name
Approved symbol：EVA1A-AS
Approved name：EVA1A antisense RNA
HGNC ID：55283
Alias symbol:EVA1A-AS1
RefSeq ID:NR_110281
Characteristics
Please input information here.
Function
Hepatocellular carcinoma (HCC) specific intronic long noncoding antisense (lnc-AS) RNA, the EVA1A-AS gene, is located within the second intron (I2) of the EVA1A gene (EVA-1 homolog A) that encodes an anti-proliferation factor[1].
EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression[1].
Regulation
Depletion of EVA1A-AS suppressed cell proliferation of HepG2 cells by upregulation of EVA1A. Overexpression of EVA1A caused cell death at the G2/M phase via microtubule catastrophe.[1].
Expression
suppressed EVA1A expression levels are negatively correlated with differentiation grade in 365 primary HCCs, while EVA1A-AS expression levels are positively correlated with patient survival.[1].
Diseases
- Hepatocellular carcinoma.[1].
Labs working on this lncRNA
- Institut fuer Biochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623, Hannover, Germany.[1]
- Klinik für Orthopädie OE8893, Medizinische Hochschule Hannover, Stadtfelddamm 34, D-30625, Hannover, Germany.[1]
- Zentrale Forschungseinrichtung Genomics OE 9415, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623, Hannover, Germany.[1]
- Institut fuer Biochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623, Hannover, Germany. Tran.Doan@MH-Hannover.de.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Niehus SE, Allister AB, Hoffmann A, Wiehlmann L, Tamura T, Tran DDH. Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner. Sci Rep. 2019 Nov 21;9(1):17319. doi: 10.1038/s41598-019-53944-2. PMID: 31754186;
