Difference between revisions of "ENST00000414795.1"

From LncRNAWiki
Jump to: navigation, search
(Created page with "Please input one-sentence summary here. ==Annotated Information== ===Transcriptomic Nomeclature=== Please input transcriptomic nomeclature information here. ===Functio...")
 
 
(8 intermediate revisions by 4 users not shown)
Line 1: Line 1:
−
Please input one-sentence summary here.
+
''NRIR''(also namedlncRNA-CMPK2), a spliced, polyadenylated nuclear transcript that was induced by IFN acts as a negative regulator of the IFN response.
  
 
==Annotated Information==
 
==Annotated Information==
−
===Transcriptomic Nomeclature===
+
===Name===
−
Please input transcriptomic nomeclature information here.
+
''NRIR'': negative regulator of interferon response (non-protein coding)(HGNC nomenclature)
  
 +
''lncRNA-CMPK2''<ref name="ref1" />
 +
 +
LncBook ID: [https://bigd.big.ac.cn/lncbook/transcript?transid=HSALNT0026673 HSALNT0026673]
 +
 +
===Cellular Localization===
 +
* nuclear
 +
[[File:lncRNA-CMPK2.jpg|right|thumb|400px|'''Characterization of lncRNA-CMPK2''' <ref name="ref1" />.]]
 +
 +
===Characteristics===
 +
''LncRNA-CMPK2'', which was locacted on chromosome 2p25.2 and spans 832 bp long, was a spliced, polyadenylated nuclear transcript that was induced by IFN in diverse cell types from human and mouse<ref name="ref1" />.
 +
 
===Function===
 
===Function===
−
Please input function information here.
+
The IFN-induced lncRNA-CMPK2 acts as a negative regulator of the IFN response, at least partially through suppression of transcription of a subset of antiviral ISGs. Further, the level of lncRNA-CMPK2 was increased in liver samples from patients chronically infected with HCV<ref name="ref1" />.
  
 
===Regulation===
 
===Regulation===
−
Please input regulation information here.
+
LncRNA-CMPK2 is a bona fide ISG induced by both type I and type II IFNs<ref name="ref1" />.
−
 
 
−
===Expression===
 
−
Please input expression information here.
 
−
 
 
−
===Allelic Information and Variation===
 
−
Please input allelic information and variation information here.
 
  
 
===Evolution===
 
===Evolution===
−
Please input evolution information here.
+
IFN-mediated induction of lncRNA-CMPK2 is likely conserved among mammals and is not tissue-specific, but rather part of the global transcriptional response to IFN stimulation<ref name="ref1" />.
−
 
 
−
You can also add sub-section(s) at will.
 
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
−
Please input related labs here.
+
* Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA<ref name="ref1" />
  
 
==References==
 
==References==
−
Please input cited references here.
+
<references>
 +
<ref name="ref1">Kambara H, Niazi F, Kostadinova L, Moonka DK, Siegel CT, Post AB, et al. Negative regulation of the interferon response by an interferon-induced long non-coding RNA[J]. Nucleic acids research. 2014,42(16):10668-80.</ref>(1)
 +
</references>
  
 
{{basic|
 
{{basic|
 
tID = ENST00000414795.1|
 
tID = ENST00000414795.1|
 
source = Gencode19|
 
source = Gencode19|
−
same = lnc-CMPK2-1:1,NONHSAT068918|
+
same = lnc-CMPK2-1:1,NONHSAT068918,''NRIR'',''lncRNA-CMPK2''|
 
classification = intergenic|
 
classification = intergenic|
 
length = 506 nt|
 
length = 506 nt|
Line 42: Line 47:
 
sequence = <dnaseq>TTCAATCCCACCCTTCCTTACCAGATACTAAAGTCATTTCTACCTTTCCTCTTGAGATTTGCTGTTAGATATTAGAACTTCTCTTTGTCACATACTTACAGGGAGATTTTGATTATCCATGGGATTCCATTCATAACCTCATAAACCACCCCCACGAAGAAATTATATATCTCGAAGAGGTTATATGGGCACATTGTGAGATGGTGGCCTCCCATGAGCCAAGAAAAGAGGGCTTAAAATGAATCCTACCTGGCTGGCACCTTGATCTTGGACTTCCTAGCATCCAGAAATGTGACATGGTTTTCTGGTGCCTTGGCAACTGCTCACGATGCATGGGAAGACTAAACACTTTGTGTACAGCATTCTGTCTCATCCAGTGAAGACTTCCTCTGGATTATTGCAGCAGACACCTCTAACCTCCTTAATCTGTACTGAATCTTGCTCTGTCGCCAGGCTGGAGTGCAGTGGTGCGATATTGGCTCACTGCAACCTCCGCCTCTCGGGTT</dnaseq>|
 
sequence = <dnaseq>TTCAATCCCACCCTTCCTTACCAGATACTAAAGTCATTTCTACCTTTCCTCTTGAGATTTGCTGTTAGATATTAGAACTTCTCTTTGTCACATACTTACAGGGAGATTTTGATTATCCATGGGATTCCATTCATAACCTCATAAACCACCCCCACGAAGAAATTATATATCTCGAAGAGGTTATATGGGCACATTGTGAGATGGTGGCCTCCCATGAGCCAAGAAAAGAGGGCTTAAAATGAATCCTACCTGGCTGGCACCTTGATCTTGGACTTCCTAGCATCCAGAAATGTGACATGGTTTTCTGGTGCCTTGGCAACTGCTCACGATGCATGGGAAGACTAAACACTTTGTGTACAGCATTCTGTCTCATCCAGTGAAGACTTCCTCTGGATTATTGCAGCAGACACCTCTAACCTCCTTAATCTGTACTGAATCTTGCTCTGTCGCCAGGCTGGAGTGCAGTGGTGCGATATTGGCTCACTGCAACCTCCGCCTCTCGGGTT</dnaseq>|
 
}}
 
}}
−
[[Category:Intergenic]]
+
[[Category:Intergenic]][[Category:lnc-CMPK2-1]][[Category:NONHSAG026902]][[Category:Transcripts]]

Latest revision as of 11:52, 11 August 2019

NRIR(also namedlncRNA-CMPK2), a spliced, polyadenylated nuclear transcript that was induced by IFN acts as a negative regulator of the IFN response.

Annotated Information

Name

NRIR: negative regulator of interferon response (non-protein coding)(HGNC nomenclature)

lncRNA-CMPK2[1]

LncBook ID: HSALNT0026673

Cellular Localization

  • nuclear
Characterization of lncRNA-CMPK2 [1].

Characteristics

LncRNA-CMPK2, which was locacted on chromosome 2p25.2 and spans 832 bp long, was a spliced, polyadenylated nuclear transcript that was induced by IFN in diverse cell types from human and mouse[1].

Function

The IFN-induced lncRNA-CMPK2 acts as a negative regulator of the IFN response, at least partially through suppression of transcription of a subset of antiviral ISGs. Further, the level of lncRNA-CMPK2 was increased in liver samples from patients chronically infected with HCV[1].

Regulation

LncRNA-CMPK2 is a bona fide ISG induced by both type I and type II IFNs[1].

Evolution

IFN-mediated induction of lncRNA-CMPK2 is likely conserved among mammals and is not tissue-specific, but rather part of the global transcriptional response to IFN stimulation[1].

Labs working on this lncRNA

  • Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Kambara H, Niazi F, Kostadinova L, Moonka DK, Siegel CT, Post AB, et al. Negative regulation of the interferon response by an interferon-induced long non-coding RNA[J]. Nucleic acids research. 2014,42(16):10668-80.

Basic Information

Transcript ID

ENST00000414795.1

Source

Gencode19

Same with

lnc-CMPK2-1:1,NONHSAT068918,NRIR,lncRNA-CMPK2

Classification

intergenic

Length

506 nt

Genomic location

chr2-:6969011..6980595

Exon number

4

Exons

6969011..6969086,6970099..6970237,6973445..6973561,6980422..6980595

Genome context

Sequence
000001 TTCAATCCCA CCCTTCCTTA CCAGATACTA AAGTCATTTC TACCTTTCCT CTTGAGATTT GCTGTTAGAT ATTAGAACTT 000080
000081 CTCTTTGTCA CATACTTACA GGGAGATTTT GATTATCCAT GGGATTCCAT TCATAACCTC ATAAACCACC CCCACGAAGA 000160
000161 AATTATATAT CTCGAAGAGG TTATATGGGC ACATTGTGAG ATGGTGGCCT CCCATGAGCC AAGAAAAGAG GGCTTAAAAT 000240
000241 GAATCCTACC TGGCTGGCAC CTTGATCTTG GACTTCCTAG CATCCAGAAA TGTGACATGG TTTTCTGGTG CCTTGGCAAC 000320
000321 TGCTCACGAT GCATGGGAAG ACTAAACACT TTGTGTACAG CATTCTGTCT CATCCAGTGA AGACTTCCTC TGGATTATTG 000400
000401 CAGCAGACAC CTCTAACCTC CTTAATCTGT ACTGAATCTT GCTCTGTCGC CAGGCTGGAG TGCAGTGGTG CGATATTGGC 000480
000481 TCACTGCAAC CTCCGCCTCT CGGGTT
[back to top]
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=ENST00000414795.1&oldid=1276266"