Difference between revisions of "NONHSAT034251"

From LncRNAWiki
Jump to: navigation, search
 
(9 intermediate revisions by 6 users not shown)
Line 2: Line 2:
  
 
==Annotated Information==
 
==Annotated Information==
−
===Transcriptomic Nomeclature===
+
===Name===
−
Please input transcriptomic nomeclature information here.
+
Approved symbol: ATXN8OS
 +
 
 +
Approved name: ATXN8 opposite strand lncRNA
 +
 
 +
HGNC ID: HGNC:10561
 +
 
 +
Previous symbols: SCA8; KLHL1AS
 +
 
 +
Previous names: spinocerebellar ataxia 8; kelch-like 1 antisense (Drosophila) ; ATXN8 opposite strand (non-protein coding)
 +
 
 +
Alias symbols: NCRNA00003
 +
 
 +
Alias names: non-protein coding RNA 3
 +
 
 +
RefSeq ID: NR_002717
 +
 
 +
LncBook ID: [https://bigd.big.ac.cn/lncbook/transcript?transid=HSALNT0203415 HSALNT0203415]
 +
 
 +
===Characteristics===
 +
~1.5kb spliced transcript, located on chromosome 13q21<ref name="ref1" />.Antisense to the KLHL1 gene (homolog of the Drosophila KELCH gene) in a bidirectional transcriptional orientation (overlapping in the first exon).
  
 
===Function===
 
===Function===
−
Please input function information here.
+
Ectopic expression in Drosophila induces late-onset, progressive neurodegeneration in the retina.
 +
 
 +
Predicted gene product underpinning the triplet repeat expansion-induced neurodegenerative disease Spinocerebellar Ataxia 8.
 +
 
 +
Associates with the RNA binding protein staufen.
 +
 
 +
===Expression===
 +
Please input expression information here.
  
 
===Regulation===
 
===Regulation===
 
Please input regulation information here.
 
Please input regulation information here.
  
−
===Expression===
+
===Disease===
−
Please input expression information here.
+
Myotonic dystrophy (DM) <ref name="ref1" />
 +
 
 +
===Conservation===
 +
KLHL1AS promoter is conserved between human and mouse. However, the mouse gene is not spliced.
 +
 
 +
===Misc===
 +
Please input misc information here.
 +
 
 +
===Transcriptomic Nomeclature===
 +
Please input transcriptomic nomeclature information here.
  
 
===Allelic Information and Variation===
 
===Allelic Information and Variation===
Line 23: Line 58:
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
−
Please input related labs here.
+
* Department of Neurology, Institute of Human Genetics, University of Minnesota, Minneapolis 55455, USA<ref name="ref1" />.
  
 
==References==
 
==References==
−
Please input cited references here.
+
<references>
 +
<ref name="ref1"> Koob MD, Moseley ML, Schut LJ, et al. An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8)[J]. Nat Genet, 1999, 21: 379-384.
 +
</ref>(1)
 +
</references>
 +
 
 +
[http://www.lncrnadb.org/sca8/ Annotation originally sourced from lncRNAdb.]
  
 
{{basic|
 
{{basic|
Line 42: Line 82:
 
sequence = <dnaseq>ATCCTTCACCTGTTGCCTGGCTAGAGTTGTCTGGCTCCACTTTGAGCTCTTGCAGAACCAGCCCTTTTTCGTGTGGTCCAGGAAAGTCCATGCCTGGCACCACCTCCTCCTCTAGTGACTCCACGTAGAAGAGAGTCCTGGCTGGCTGCTGAGTGCCCTGCCCAGGAGCCCCTTGCTGCAGCCTCGTGGCAACTGGAAGCAGGGTGCCATTCAGCGGATTGAAGGAAGAGGAGGAAGAGGACGGGGAGGACGATGAAGAGGAAGAGGAGGAAGGCTTCTTCCAGAAAGTGCTCACACCGCTTCTCTCTTGGCTTTTGAGCAGGCGACTCTGGCTGGGTCCCCAGTGCTCAAAGCTGCCACTGCCGTCCTGTTGCAGGCAGCCTCCCCCCGCCGGGCCGCCGGTGGAAGGAGACGGGTGGCTGAAGAGTTTCCAGCGGAGTCGCAGAATGTGCTTCACATCGAAGTCTTTTCGCCCAGAGCCTGACATGCTTTACGCACAGAAGGCAAAAGGCTGGCAGCTCACGCAGGATTCTGGAGGCTGGGAAGTTCAAGACCAATGCACGAGAATTTGGTCTAAAGAGAATCTTCTTGCTCTGAACACACATAGTAGAAGGCAGAAGGGCAAGAGAGAGAACAAAGTCTGTGTCTCCACATGGCAGAAGAGCAGAGGAGACAGAACCTACTCCTCTATGGCAACCACCCCATCAATGACAAAAATCCTAGAAGGATGTATGTATAGGAAGTTGAAGTGTTGAGAAGAGAATGGCTCAGAGTCAAGCGGGAACAAGATTCAAACTTCAGAGAGAGAGGGAAGAAAAACATTTAAATATATCTGGCATAATCCAAGACTATTTACGACAAGTGTTCTGTGTTTCTAATAATAAAACAGACTTCACCTCGGAGTACCTGCAGAACTGGGACCCCAATGACCAGGGAGAATGAAGAACAACTTGTTGAAGATTGCCTTTTCTGACTCCCAGCTTCCACGGAGAGATTAACTCTGTTGGCTGAAGCCCTATTCCCAATTCCTTGGCTAGACCCTGGGTCCTTCATGTTAGAAAACCTGGCTTTACTACTACTACTACTACTACTACTACTACTACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCATTTTTTAAAAATATATTATCTTATTTTACTATTTGATGTTATAATTGTTATATATTTTTCCACACTTCCTCATACTGCTTATCTCTTACTTAAGAATTTATGAATAAAGAATTGATTTTTCAATACATCCTTCCAAAAATTATCTGATGTTGAGTTAGTTGCTCTCTCTTGTGCATTCTCAGTCCTCACAAGCCTTTCTCAAACACAATGTTTATCAAAGAAAATTGTAGCAACCAATATACTTAGTGGAATTTCTCACAGAGTTTGAGTGTAGGAAACAGTATTCACTGTATATTAGTCATTTTGCTCCCAATAGAAGGTGC</dnaseq>|
 
sequence = <dnaseq>ATCCTTCACCTGTTGCCTGGCTAGAGTTGTCTGGCTCCACTTTGAGCTCTTGCAGAACCAGCCCTTTTTCGTGTGGTCCAGGAAAGTCCATGCCTGGCACCACCTCCTCCTCTAGTGACTCCACGTAGAAGAGAGTCCTGGCTGGCTGCTGAGTGCCCTGCCCAGGAGCCCCTTGCTGCAGCCTCGTGGCAACTGGAAGCAGGGTGCCATTCAGCGGATTGAAGGAAGAGGAGGAAGAGGACGGGGAGGACGATGAAGAGGAAGAGGAGGAAGGCTTCTTCCAGAAAGTGCTCACACCGCTTCTCTCTTGGCTTTTGAGCAGGCGACTCTGGCTGGGTCCCCAGTGCTCAAAGCTGCCACTGCCGTCCTGTTGCAGGCAGCCTCCCCCCGCCGGGCCGCCGGTGGAAGGAGACGGGTGGCTGAAGAGTTTCCAGCGGAGTCGCAGAATGTGCTTCACATCGAAGTCTTTTCGCCCAGAGCCTGACATGCTTTACGCACAGAAGGCAAAAGGCTGGCAGCTCACGCAGGATTCTGGAGGCTGGGAAGTTCAAGACCAATGCACGAGAATTTGGTCTAAAGAGAATCTTCTTGCTCTGAACACACATAGTAGAAGGCAGAAGGGCAAGAGAGAGAACAAAGTCTGTGTCTCCACATGGCAGAAGAGCAGAGGAGACAGAACCTACTCCTCTATGGCAACCACCCCATCAATGACAAAAATCCTAGAAGGATGTATGTATAGGAAGTTGAAGTGTTGAGAAGAGAATGGCTCAGAGTCAAGCGGGAACAAGATTCAAACTTCAGAGAGAGAGGGAAGAAAAACATTTAAATATATCTGGCATAATCCAAGACTATTTACGACAAGTGTTCTGTGTTTCTAATAATAAAACAGACTTCACCTCGGAGTACCTGCAGAACTGGGACCCCAATGACCAGGGAGAATGAAGAACAACTTGTTGAAGATTGCCTTTTCTGACTCCCAGCTTCCACGGAGAGATTAACTCTGTTGGCTGAAGCCCTATTCCCAATTCCTTGGCTAGACCCTGGGTCCTTCATGTTAGAAAACCTGGCTTTACTACTACTACTACTACTACTACTACTACTACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCATTTTTTAAAAATATATTATCTTATTTTACTATTTGATGTTATAATTGTTATATATTTTTCCACACTTCCTCATACTGCTTATCTCTTACTTAAGAATTTATGAATAAAGAATTGATTTTTCAATACATCCTTCCAAAAATTATCTGATGTTGAGTTAGTTGCTCTCTCTTGTGCATTCTCAGTCCTCACAAGCCTTTCTCAAACACAATGTTTATCAAAGAAAATTGTAGCAACCAATATACTTAGTGGAATTTCTCACAGAGTTTGAGTGTAGGAAACAGTATTCACTGTATATTAGTCATTTTGCTCCCAATAGAAGGTGC</dnaseq>|
 
}}
 
}}
−
[[Category:Intergenic]]
+
[[Category:Intergenic]][[Category:NONHSAG013730]][[Category:Transcripts]][[Category:Transcripts]]
−
 
 
−
{{lncrnadb|
 
−
tID = NONHSAT034251|
 
−
ltID = SCA8|
 
−
ann = <tab class=wikitable sep=tab head=top>
 
−
Section Description
 
−
ID SCA8
 
−
Characteristics ~1.5kb spliced transcript. Antisense to the KLHL1 gene (homolog of the Drosophila KELCH gene) in a bidirectional transcriptional orientation (overlapping in the first exon).
 
−
Expression N/A
 
−
Function Ectopic expression in Drosophila induces late-onset, progressive neurodegeneration in the retina. Predicted gene product underpinning the triplet repeat expansion-induced neurodegenerative disease Spinocerebellar Ataxia 8. Associates with the RNA binding protein staufen.
 
−
Conservation KLHL1AS promoter is conserved between human and mouse. However, the mouse gene is not spliced.
 
−
Name Spinocerebellar ataxia 8 (SCA8) RNA. KLHL1AS: kelch-like 1 (Drosophila) antisense. ATXN8OS: ataxin 8 opposite strand
 
−
</tab>|
 
−
}}
 

Latest revision as of 13:58, 11 August 2019

Please input one-sentence summary here.

Annotated Information

Name

Approved symbol: ATXN8OS

Approved name: ATXN8 opposite strand lncRNA

HGNC ID: HGNC:10561

Previous symbols: SCA8; KLHL1AS

Previous names: spinocerebellar ataxia 8; kelch-like 1 antisense (Drosophila) ; ATXN8 opposite strand (non-protein coding)

Alias symbols: NCRNA00003

Alias names: non-protein coding RNA 3

RefSeq ID: NR_002717

LncBook ID: HSALNT0203415

Characteristics

~1.5kb spliced transcript, located on chromosome 13q21[1].Antisense to the KLHL1 gene (homolog of the Drosophila KELCH gene) in a bidirectional transcriptional orientation (overlapping in the first exon).

Function

Ectopic expression in Drosophila induces late-onset, progressive neurodegeneration in the retina.

Predicted gene product underpinning the triplet repeat expansion-induced neurodegenerative disease Spinocerebellar Ataxia 8.

Associates with the RNA binding protein staufen.

Expression

Please input expression information here.

Regulation

Please input regulation information here.

Disease

Myotonic dystrophy (DM) [1]

Conservation

KLHL1AS promoter is conserved between human and mouse. However, the mouse gene is not spliced.

Misc

Please input misc information here.

Transcriptomic Nomeclature

Please input transcriptomic nomeclature information here.

Allelic Information and Variation

Please input allelic information and variation information here.

Evolution

Please input evolution information here.

You can also add sub-section(s) at will.

Labs working on this lncRNA

  • Department of Neurology, Institute of Human Genetics, University of Minnesota, Minneapolis 55455, USA[1].

References

  1. ↑ 1.0 1.1 1.2 Koob MD, Moseley ML, Schut LJ, et al. An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8)[J]. Nat Genet, 1999, 21: 379-384.

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID

NONHSAT034251

Source

NONCODE4.0

Same with

,

Classification

intergenic

Length

1472 nt

Genomic location

chr13+:70681345..70713885

Exon number

5

Exons

70681345..70681873,70689273..70689430,70703916..70704016,70704810..70704980,70713373..70713885

Genome context

Sequence
000001 ATCCTTCACC TGTTGCCTGG CTAGAGTTGT CTGGCTCCAC TTTGAGCTCT TGCAGAACCA GCCCTTTTTC GTGTGGTCCA 000080
000081 GGAAAGTCCA TGCCTGGCAC CACCTCCTCC TCTAGTGACT CCACGTAGAA GAGAGTCCTG GCTGGCTGCT GAGTGCCCTG 000160
000161 CCCAGGAGCC CCTTGCTGCA GCCTCGTGGC AACTGGAAGC AGGGTGCCAT TCAGCGGATT GAAGGAAGAG GAGGAAGAGG 000240
000241 ACGGGGAGGA CGATGAAGAG GAAGAGGAGG AAGGCTTCTT CCAGAAAGTG CTCACACCGC TTCTCTCTTG GCTTTTGAGC 000320
000321 AGGCGACTCT GGCTGGGTCC CCAGTGCTCA AAGCTGCCAC TGCCGTCCTG TTGCAGGCAG CCTCCCCCCG CCGGGCCGCC 000400
000401 GGTGGAAGGA GACGGGTGGC TGAAGAGTTT CCAGCGGAGT CGCAGAATGT GCTTCACATC GAAGTCTTTT CGCCCAGAGC 000480
000481 CTGACATGCT TTACGCACAG AAGGCAAAAG GCTGGCAGCT CACGCAGGAT TCTGGAGGCT GGGAAGTTCA AGACCAATGC 000560
000561 ACGAGAATTT GGTCTAAAGA GAATCTTCTT GCTCTGAACA CACATAGTAG AAGGCAGAAG GGCAAGAGAG AGAACAAAGT 000640
000641 CTGTGTCTCC ACATGGCAGA AGAGCAGAGG AGACAGAACC TACTCCTCTA TGGCAACCAC CCCATCAATG ACAAAAATCC 000720
000721 TAGAAGGATG TATGTATAGG AAGTTGAAGT GTTGAGAAGA GAATGGCTCA GAGTCAAGCG GGAACAAGAT TCAAACTTCA 000800
000801 GAGAGAGAGG GAAGAAAAAC ATTTAAATAT ATCTGGCATA ATCCAAGACT ATTTACGACA AGTGTTCTGT GTTTCTAATA 000880
000881 ATAAAACAGA CTTCACCTCG GAGTACCTGC AGAACTGGGA CCCCAATGAC CAGGGAGAAT GAAGAACAAC TTGTTGAAGA 000960
000961 TTGCCTTTTC TGACTCCCAG CTTCCACGGA GAGATTAACT CTGTTGGCTG AAGCCCTATT CCCAATTCCT TGGCTAGACC 001040
001041 CTGGGTCCTT CATGTTAGAA AACCTGGCTT TACTACTACT ACTACTACTA CTACTACTAC TACTGCTGCT GCTGCTGCTG 001120
001121 CTGCTGCTGC TGCTGCTGCT GCTGCTGCAT TTTTTAAAAA TATATTATCT TATTTTACTA TTTGATGTTA TAATTGTTAT 001200
001201 ATATTTTTCC ACACTTCCTC ATACTGCTTA TCTCTTACTT AAGAATTTAT GAATAAAGAA TTGATTTTTC AATACATCCT 001280
001281 TCCAAAAATT ATCTGATGTT GAGTTAGTTG CTCTCTCTTG TGCATTCTCA GTCCTCACAA GCCTTTCTCA AACACAATGT 001360
001361 TTATCAAAGA AAATTGTAGC AACCAATATA CTTAGTGGAA TTTCTCACAG AGTTTGAGTG TAGGAAACAG TATTCACTGT 001440
001441 ATATTAGTCA TTTTGCTCCC AATAGAAGGT GC
[back to top]
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=NONHSAT034251&oldid=1276330"