Difference between revisions of "NONHSAT015489"

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Please input one-sentence summary here.
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==Annotated Information==
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===Approved symbol===
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FAS-AS1
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===Previous symbols===
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"FAS antisense RNA (non-protein coding)", "FAS antisense RNA 1 (non-protein coding)", FAS-AS, FASAS, SAF
  
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==Annotated Information==
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===Chromosomal location===
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===Name===
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10q24.1
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SAF
 
  
 
===Characteristics===
 
===Characteristics===
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1556 bases; transcribed from the opposite strand of intron 1 of the human Fas gene.
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FAS-AS1 is 1556 bp long and is entirely originated from intron 1 of the Fas gene.<ref name="ref1" />
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FAS-AS1 binds to RBM5 and interferes with RBM5-mediated skipping of exon 6.<ref name="ref2" />
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===Function===
 
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In vitro over-expression of Saf protects cells from Fas-mediated apoptosis.
 
  
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Over-expression of Saf induces alternative splicing of FAS transcripts, wherein an alternative exon overlapped by the antisense RNA is retained and non-adjacent 3' exons are skipped. This results in Fas proteins that are not able to anchor to the cell membrane, therefore regulating Fas-mediated but not TNF-alpha-mediated apoptosis.
 
 
===Expression===
 
===Expression===
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Detected in several human tissues (such as heart, placenta, liver, muscle and pancreas, as well as kidney in lower levels). It was also detected in different cancer cell lines, including Jurkat (acute T-cell leukemia), MES-SA (uterine carcinoma) and U-937 (Histocytic Lymphoma); moderately expressed in CA46 (Burkitt,s lym- phoma), Raji (Burkitt,s lymphoma) and only slightly expressed in MG-63 (osteosarcoma).
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FAS-AS1 expresses in heart, placenta, liver, muscle, kidney and pancreas.<ref name="ref1" />
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The expression of FAS-AS1 in lymphoma is repressed by promoter hyper-methylation.<ref name="ref2" />
  
 
===Conservation===
 
===Conservation===
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Saf gene appears to be conserved among the primates and is absent in the rodents.
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FAS-AS1 appears to be conserved among the primates and is absent in the rodents.<ref name="ref1" />
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===Diseases===
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* B-cell lymphoma
  
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===Misc===
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===Function===
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Please input misc information here.
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FAS-AS1 regulates skipping of exon 6 through direct interaction with RBM5 reveals a novel layer of modulation of the Fas death receptor signaling in human lymphomas.<ref name="ref2" />
  
 
===Transcriptomic Nomeclature===
 
===Transcriptomic Nomeclature===
 
Please input transcriptomic nomeclature information here.
 
Please input transcriptomic nomeclature information here.
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===Regulation===
 
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Please input regulation information here.
 
  
 
===Allelic Information and Variation===
 
===Allelic Information and Variation===
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You can also add sub-section(s) at will.
 
You can also add sub-section(s) at will.
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
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Please input related labs here.
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* Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan, ROC <ref name="ref1" />
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* Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<ref name="ref2" />
  
 
==References==
 
==References==
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Please input cited references here.
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<references>
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<ref name="ref1"> Maurillo, L., G. Del Poeta, A. Venditti, F. Buccisano, A. Battaglia, S. Santinelli, T. Caravita, A. M. Epiceno, B. Del Moro, A. Tamburini, A. Picardi, G. Suppo, G. Catalano, A. Bruno, and S. Amadori. "Quantitative Analysis of Fas and Bcl-2 Expression in Hematopoietic Precursors." Haematologica 86, no. 3 (2001): 237-43.</ref>(1)
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<ref name="ref2"> Sehgal, L., R. Mathur, F. K. Braun, J. F. Wise, Z. Berkova, S. Neelapu, L. W. Kwak, and F. Samaniego. "Fas-Antisense 1 Lncrna and Production of Soluble Versus Membrane Fas in B-Cell Lymphoma." Leukemia 28, no. 12 (2014): 2376-87.</ref>(2)
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</references>
  
 
{{basic|
 
{{basic|
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sequence = <dnaseq>TTCCAAGTAATTAGCACTTTGCATCTATTTTATTTATTGCTACTACTAAGAAAACATAACCGTGAAGGCATAAAAGCAAACATTTTCTGTAGACACATGAGGTGACACAAGAGTGTTGAAACTTCTTTAAGGATAAAGGCCTGATGTTAGGCATGTCGTGAGCGCAAAACCAATTTCTGTGTAACTAAATTTAAAAGAGTCATATTAGAGGGGAGAAATGGAAGATAAACTGCAAAACGTAAACAATGATTACTTAGGTGATAGAGTTATGTCTGATCTTTGTATTTGACTCATCTGCATTTATAAATTTTATTTAATAAGCCTTAATTTCCTAGGCCATATATCATATACAAATATAAGTTATACCTAACTTATAGGTATTATAATATGTATATATACATAAATGTATGAATATTTACATATGCGTGTGTGTGTGTATTCTTTCAGAAAAGCAAAGTTTTCTTCGGGCTTTAAACACGCAGCCTCTGGTAAAGGTGCTATTGGTACAAAAGTTCAACAAGCATAGCTCCAAGCTTTGACAATTTTCTTACACTTTACTAATACTGCTGTCCAAAAACTATGAGATTTTCAAAGCAGCCAACATTGCAGTGGTGCAATGGTTAATAACAAGAGAGAGAAGAGTGTGGCCTGAGGTTGTATAAATGTTTTCTCAATCTTGAATCATTAATTTTCTCCAAGGAAGTTTCTAAAGAATCCCAAATAGTGCACACTATTTCTGAAAGGAACAGGATTTTTTTTTCTAATCATAAAATGGACCCAGACATCTCAGCCTCTTGGTGTAATCTGGATATCAGATGCAATCAGCGAACAGCCTGAGTTTTGGAATTAGATCTGAGTTCAATCCCATATCTCCCATTTACTAGCTGTGTGATCTTGGCTGAATTACTGAAGCTCTCTGAACCTCATTTCGCCATCTGTAAAATGGGGATGTGGTTATCTTCCCCACTACATGGCTCTCGTGAGAATCCGCGGAGATCACATTTGTAAACACTTCTCTCGCTATGCCTGGCACTTTGTTGGGGCCCAATAAAATAAAAATCCATGGACTCTCAGAGGCTCCGGTACTCAAATGAGCCTCCTGGATCCACGTCTCTTTGATTAGCCATCTGCAAGCTGGCATTTCTGAGCGAGGGACTTTTCAAAACAGGCTGCTCAAGTTTCTTGGCCAATAATAGGCGCCGGGTTCTGTGCGGTGGGAACGAGTACCACCAACCCCAGCAGGAGACCAAGCAGAAATCACCATGGGAGTGCAAGCTAAGAAAGGGCAAAAGAAGAAAGAGAAGGGCAGAAAAACAAAACAAAATGAAACCACTCAGGCAGCGACTTACAGTCTTAAAGAGAGAATTCCCGGAAGGGAGACAAGGCAGTTTCTTTTTCTGTGTGACAATAAAAAACGGTAAACAAGCCTCCAGAAGCTCATTCAGCCCCCATATAACTTTTTCGAGAAAGAAAAGGTGCCGTTCTTCCGAGCCCTCCGGCTTAACCACTGCTTCGGTGCTGACTTATTTCCTACGTCTGAGAACTGCCAGAAAA</dnaseq>|
 
sequence = <dnaseq>TTCCAAGTAATTAGCACTTTGCATCTATTTTATTTATTGCTACTACTAAGAAAACATAACCGTGAAGGCATAAAAGCAAACATTTTCTGTAGACACATGAGGTGACACAAGAGTGTTGAAACTTCTTTAAGGATAAAGGCCTGATGTTAGGCATGTCGTGAGCGCAAAACCAATTTCTGTGTAACTAAATTTAAAAGAGTCATATTAGAGGGGAGAAATGGAAGATAAACTGCAAAACGTAAACAATGATTACTTAGGTGATAGAGTTATGTCTGATCTTTGTATTTGACTCATCTGCATTTATAAATTTTATTTAATAAGCCTTAATTTCCTAGGCCATATATCATATACAAATATAAGTTATACCTAACTTATAGGTATTATAATATGTATATATACATAAATGTATGAATATTTACATATGCGTGTGTGTGTGTATTCTTTCAGAAAAGCAAAGTTTTCTTCGGGCTTTAAACACGCAGCCTCTGGTAAAGGTGCTATTGGTACAAAAGTTCAACAAGCATAGCTCCAAGCTTTGACAATTTTCTTACACTTTACTAATACTGCTGTCCAAAAACTATGAGATTTTCAAAGCAGCCAACATTGCAGTGGTGCAATGGTTAATAACAAGAGAGAGAAGAGTGTGGCCTGAGGTTGTATAAATGTTTTCTCAATCTTGAATCATTAATTTTCTCCAAGGAAGTTTCTAAAGAATCCCAAATAGTGCACACTATTTCTGAAAGGAACAGGATTTTTTTTTCTAATCATAAAATGGACCCAGACATCTCAGCCTCTTGGTGTAATCTGGATATCAGATGCAATCAGCGAACAGCCTGAGTTTTGGAATTAGATCTGAGTTCAATCCCATATCTCCCATTTACTAGCTGTGTGATCTTGGCTGAATTACTGAAGCTCTCTGAACCTCATTTCGCCATCTGTAAAATGGGGATGTGGTTATCTTCCCCACTACATGGCTCTCGTGAGAATCCGCGGAGATCACATTTGTAAACACTTCTCTCGCTATGCCTGGCACTTTGTTGGGGCCCAATAAAATAAAAATCCATGGACTCTCAGAGGCTCCGGTACTCAAATGAGCCTCCTGGATCCACGTCTCTTTGATTAGCCATCTGCAAGCTGGCATTTCTGAGCGAGGGACTTTTCAAAACAGGCTGCTCAAGTTTCTTGGCCAATAATAGGCGCCGGGTTCTGTGCGGTGGGAACGAGTACCACCAACCCCAGCAGGAGACCAAGCAGAAATCACCATGGGAGTGCAAGCTAAGAAAGGGCAAAAGAAGAAAGAGAAGGGCAGAAAAACAAAACAAAATGAAACCACTCAGGCAGCGACTTACAGTCTTAAAGAGAGAATTCCCGGAAGGGAGACAAGGCAGTTTCTTTTTCTGTGTGACAATAAAAAACGGTAAACAAGCCTCCAGAAGCTCATTCAGCCCCCATATAACTTTTTCGAGAAAGAAAAGGTGCCGTTCTTCCGAGCCCTCCGGCTTAACCACTGCTTCGGTGCTGACTTATTTCCTACGTCTGAGAACTGCCAGAAAA</dnaseq>|
 
}}
 
}}
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[[Category:Intergenic]]
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[[Category:Intergenic]][[Category:NONHSAG006477]][[Category:Transcripts]][[Category:Transcripts]]

Latest revision as of 03:59, 19 September 2016

Annotated Information

Approved symbol

FAS-AS1

Previous symbols

"FAS antisense RNA (non-protein coding)", "FAS antisense RNA 1 (non-protein coding)", FAS-AS, FASAS, SAF

Chromosomal location

10q24.1

Characteristics

FAS-AS1 is 1556 bp long and is entirely originated from intron 1 of the Fas gene.[1] FAS-AS1 binds to RBM5 and interferes with RBM5-mediated skipping of exon 6.[2]

Expression

FAS-AS1 expresses in heart, placenta, liver, muscle, kidney and pancreas.[1] The expression of FAS-AS1 in lymphoma is repressed by promoter hyper-methylation.[2]

Conservation

FAS-AS1 appears to be conserved among the primates and is absent in the rodents.[1]

Diseases

  • B-cell lymphoma

Function

FAS-AS1 regulates skipping of exon 6 through direct interaction with RBM5 reveals a novel layer of modulation of the Fas death receptor signaling in human lymphomas.[2]

Transcriptomic Nomeclature

Please input transcriptomic nomeclature information here.

Allelic Information and Variation

Please input allelic information and variation information here.

Evolution

Please input evolution information here.

You can also add sub-section(s) at will.

Labs working on this lncRNA

  • Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan, ROC [1]
  • Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.[2]

References

  1. ↑ 1.0 1.1 1.2 1.3 Maurillo, L., G. Del Poeta, A. Venditti, F. Buccisano, A. Battaglia, S. Santinelli, T. Caravita, A. M. Epiceno, B. Del Moro, A. Tamburini, A. Picardi, G. Suppo, G. Catalano, A. Bruno, and S. Amadori. "Quantitative Analysis of Fas and Bcl-2 Expression in Hematopoietic Precursors." Haematologica 86, no. 3 (2001): 237-43.
  2. ↑ 2.0 2.1 2.2 2.3 Sehgal, L., R. Mathur, F. K. Braun, J. F. Wise, Z. Berkova, S. Neelapu, L. W. Kwak, and F. Samaniego. "Fas-Antisense 1 Lncrna and Production of Soluble Versus Membrane Fas in B-Cell Lymphoma." Leukemia 28, no. 12 (2014): 2376-87.

Basic Information

Transcript ID

NONHSAT015489

Source

NONCODE4.0

Same with

,

Classification

intergenic

Length

1554 nt

Genomic location

chr10-:90751179..90752732

Exon number

1

Exons

90751179..90752732

Genome context

Sequence
000001 TTCCAAGTAA TTAGCACTTT GCATCTATTT TATTTATTGC TACTACTAAG AAAACATAAC CGTGAAGGCA TAAAAGCAAA 000080
000081 CATTTTCTGT AGACACATGA GGTGACACAA GAGTGTTGAA ACTTCTTTAA GGATAAAGGC CTGATGTTAG GCATGTCGTG 000160
000161 AGCGCAAAAC CAATTTCTGT GTAACTAAAT TTAAAAGAGT CATATTAGAG GGGAGAAATG GAAGATAAAC TGCAAAACGT 000240
000241 AAACAATGAT TACTTAGGTG ATAGAGTTAT GTCTGATCTT TGTATTTGAC TCATCTGCAT TTATAAATTT TATTTAATAA 000320
000321 GCCTTAATTT CCTAGGCCAT ATATCATATA CAAATATAAG TTATACCTAA CTTATAGGTA TTATAATATG TATATATACA 000400
000401 TAAATGTATG AATATTTACA TATGCGTGTG TGTGTGTATT CTTTCAGAAA AGCAAAGTTT TCTTCGGGCT TTAAACACGC 000480
000481 AGCCTCTGGT AAAGGTGCTA TTGGTACAAA AGTTCAACAA GCATAGCTCC AAGCTTTGAC AATTTTCTTA CACTTTACTA 000560
000561 ATACTGCTGT CCAAAAACTA TGAGATTTTC AAAGCAGCCA ACATTGCAGT GGTGCAATGG TTAATAACAA GAGAGAGAAG 000640
000641 AGTGTGGCCT GAGGTTGTAT AAATGTTTTC TCAATCTTGA ATCATTAATT TTCTCCAAGG AAGTTTCTAA AGAATCCCAA 000720
000721 ATAGTGCACA CTATTTCTGA AAGGAACAGG ATTTTTTTTT CTAATCATAA AATGGACCCA GACATCTCAG CCTCTTGGTG 000800
000801 TAATCTGGAT ATCAGATGCA ATCAGCGAAC AGCCTGAGTT TTGGAATTAG ATCTGAGTTC AATCCCATAT CTCCCATTTA 000880
000881 CTAGCTGTGT GATCTTGGCT GAATTACTGA AGCTCTCTGA ACCTCATTTC GCCATCTGTA AAATGGGGAT GTGGTTATCT 000960
000961 TCCCCACTAC ATGGCTCTCG TGAGAATCCG CGGAGATCAC ATTTGTAAAC ACTTCTCTCG CTATGCCTGG CACTTTGTTG 001040
001041 GGGCCCAATA AAATAAAAAT CCATGGACTC TCAGAGGCTC CGGTACTCAA ATGAGCCTCC TGGATCCACG TCTCTTTGAT 001120
001121 TAGCCATCTG CAAGCTGGCA TTTCTGAGCG AGGGACTTTT CAAAACAGGC TGCTCAAGTT TCTTGGCCAA TAATAGGCGC 001200
001201 CGGGTTCTGT GCGGTGGGAA CGAGTACCAC CAACCCCAGC AGGAGACCAA GCAGAAATCA CCATGGGAGT GCAAGCTAAG 001280
001281 AAAGGGCAAA AGAAGAAAGA GAAGGGCAGA AAAACAAAAC AAAATGAAAC CACTCAGGCA GCGACTTACA GTCTTAAAGA 001360
001361 GAGAATTCCC GGAAGGGAGA CAAGGCAGTT TCTTTTTCTG TGTGACAATA AAAAACGGTA AACAAGCCTC CAGAAGCTCA 001440
001441 TTCAGCCCCC ATATAACTTT TTCGAGAAAG AAAAGGTGCC GTTCTTCCGA GCCCTCCGGC TTAACCACTG CTTCGGTGCT 001520
001521 GACTTATTTC CTACGTCTGA GAACTGCCAG AAAA
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